Meadow foxtail
Summary
Alopecurus pratensis is a tall perennial grass species with a broad native range, and one of the most important sources of airborne pollen in temperate regions. Meadow foxtail contributes to seasonal and perennial rhinitis symptoms of grass pollen allergic individuals, however there is some evidence that continuous exposure to cowshed dust containing A. pratensis pollen may elicit some degree of immuno-modulation which protects children against allergy.
Route Of Exposure
Main
A. pratensis is one of the first grasses to begin growth in the spring and one of the most important sources of airborne grass pollen in temperate regions.
Clinical Relevance
Anecdotal evidence suggests that pollen produced by A. pratensis may induce hay fever, asthma and conjunctivitis in sensitized individuals{Holopainen, 1979 #7;Kmenta, 2017 #9}; however, very few studies specifically assessing the role of A. pratensis have been reported to date.
A high degree of skin reactivity has been observed in patients with hay fever exposed to unfractionated extracts of grass pollens, including meadow foxtail. In 1979, an assessment of 770 patients in Nordic countries with seasonal and perennial nasal symptoms determined that Alopecurus was an important contributor to positive reactions to pollen.
More recently, A. pratensis was identified as a potentially relevant allergen in a population study of pollen allergy in the Sarajevo region (Bosnia and Herzegovina) during 2002. In 2015, A. pratensis was also shown to be a significant contributor to aerial pollen concentration and rhinitis symptoms of grass pollen allergy sufferers in Berlin (Germany) during the grass pollen season.
However, mice treated with intranasal applications of cowshed dust containing plant material from hay and grass fodder (primarily A. pratensis) had significantly lower IgE antibodies than mice treated with sham intranasal formulations. These authors were the first to demonstrate that arabinogalactan from A. pratensis induced IL-10 production and protected the mice from developing atopic sensitization, allergic airway inflammation and airway hyperreactivity. Arabinogalactan is a major component of grass pollen, and the concentration of grass pollen in the air of cowsheds has been correlated with allergy protection in children who live on farms.
Cross-Reactivity
Variable degrees of cross-reactivity may occur between grass pollen species sharing Group 1 and/or Group 5 grass allergens. An in vitro analysis of 13 grasses demonstrated a high degree of structural homology and extensive epitope sharing between meadow foxtail, Timothy grass, wild rye, cultivated rye, fescue meadow grass, meadow grass, orchard grass, velvet grass, redtop grass, crested dogstail grass, brome grass, false oat grass and sweet vernal grass.
Carbohydrate-reactive IgE antibodies attributed to grass pollen sensitization have been found to cross-react with glycan structures from other allergen sources, particularly vegetable foods. Extensive cross-reactivity is also possible between profilins, a family of Group 12 allergen proteins which are highly conserved throughout the plant kingdom and present in all tissues.
References
- Cabi. Alopecurus pratensis (meadow foxtail) Datasheet 2019 [cited 2021 28.11.21]. Available from: https://www.cabi.org/isc/datasheet/4361.
- Löfkvist T, Svensson G. Cutaneous reactions to pollen extracts in patients with hay fever. Special references to grass pollen recommended for treatment in fixed combination. Acta Allergol. 1975;30(2-3):96-105.
- Yang J, Du W, Pang Y. Characterization of the complete chloroplast genome of Alopecurus pratensis L. (Poaceae). Mitochondrial DNA Part B. 2021;6(8):2379-80.
- Sheley RL. Tolerance of Meadow Foxtail (Alopecurus pratensis) to Two Sulfonylurea Herbicides. Weed Technology. 2007;21(2):470-2.
- Schoth HA. Meadow Foxtail. Station Bulletin 1945;433.
- Petrescu I, Sarac I, Onisan E, Madosa E, Stroia C. Morphological aspect for the grain pollen of Alopecurus
- pratensis and Dactylis glomerata. Journal of Horticulture, Forestry and Biotechnology. 2015;19(4):89-92.
- Holopainen E, Salo OP, Tarkiainen E, Malmberg H. The most important allergens in allergic rhinitis. Acta Otolaryngol Suppl. 1979;360:16-8.
- Saracević E, Redzić S, Telacević A. [The frequency of pollen allergy at the population of Sarajevo region during the 2002 year]. Med Arh. 2005;59(4):221-3.
- Kmenta M, Bastl K, Berger U, Kramer MF, Heath MD, Pätsi S, et al. The grass pollen season 2015: a proof of concept multi-approach study in three different European cities. World Allergy Organ J. 2017;10(1):31.
- Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, et al. Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization. J Allergy Clin Immunol. 2010;126(3):648-56.e1-4.
- Sudre B, Vacheyrou M, Braun-Fahrländer C, Normand AC, Waser M, Reboux G, et al. High levels of grass pollen inside European dairy farms: a role for the allergy-protective effects of environment? Allergy. 2009;64(7):1068-73.
- Diener C, Skibbe K, Jäger L. [Identification of allergens in 5 grasses using crossed radioimmunoelectrophoresis (CRIE)]. Allerg Immunol (Leipz). 1984;30(1):14-22.
- Matthiesen F, Løwenstein H. Group V allergens in grass pollens. II. Investigation of group V allergens in pollens from 10 grasses. Clin Exp Allergy. 1991;21(3):309-20.
- Bullimore A, Batten T, Hewings S, Fischer von Weikersthal-Drachenberg KJ, Skinner M. Cross-reactivity in Grasses: Biochemical Attributes Define Exemplar Relevance. World Allergy Organ J. 2012;5(10):111-9.
- Andersson K, Lidholm J. Characteristics and immunobiology of grass pollen allergens. Int Arch Allergy Immunol. 2003;130(2):87-107