Clinical Relevance

A research physician accidently received a minor wound from a needle that had been previously used in rabbit tissue and within 15 minutes a serious anaphylactic reaction started. The authors contend that this anaphylactic reaction was due to a response mediated by IgE by trace amounts of rabbit serum proteins accidently introduced into the superficial layers of the skin.

In a study of 12 children who had had clinical reactions after ingestion of bovine meat, showed that serum albumin seems to be the main or one of the most important antigens of bovine meat. This could suggest that other animal species such as rabbit to be considered in the diet of atopic children. Serum albumin from rabbit was less frequently involved in the formation of binding with specific circulating IgE and in SPT responses. Data on cross-reactivity between meat of different animal species are useful to improve the basic knowledge of meat allergy and could contribute to solving the dietetic and clinical problems of atopic children. Watt AD et al. have reported on anaphylaxis to rabbit serum protein. A research physician accidently received a minor wound from a needle that had been previously used in rabbit tissue and within 15 minutes a serious anaphylactic reaction started. The authors contend that this anaphylactic reaction was due to a response mediated by IgE by trace amounts of rabbit serum proteins accidently introduced into the superficial layers of the skin.

Cross-Reactivity

In a study of 12 children who had had clinical reactions after ingestion of bovine meat, showed, that serum albumin seems to be the main or one of the most important antigens of bovine meat. This could suggest that other animal species such as rabbit be considered in the diet of atopic children. Serum albumin from rabbit was less frequently involved in the formation of binding with specific circulating IgE and in SPT responses