Chicken serum proteins
Summary
Direct or indirect contact with bird allergens may cause sensitisation. Bird allergens may be major components of house dust.
Clinical Relevance
Asthma, allergic rhinitis and allergic conjunctivitis may result following exposure to Chicken feathers, epithelial cells or droppings. The allergic manifestations may present as Bird Fancier´s Asthma and as so-called Bird-Egg Syndrome with symptoms such as rhinitis, urticaria and angioedema, and also gastro-intestinal problems. Contact with Chicken has been reported as a common cause of occupational asthma and allergic rhinitis.
Asthma
Contact with Chicken is a significant cause of sensitisation in poultry workers. Asthma prevalence in farmers has been found by means of a questionnaire survey to be higher for Horse breeders/groomers, Pig farmers, poultry farmers, and those working with Oats. Up to 17.4% of poultry farmers reported symptoms of asthma. In an avian slaughterhouse, workers may be exposed to Chicken feathers, as well as to serum and droppings allergens. Sensitisation in these individuals may also occur to Chicken feed.
Other diseases
Chicken serum albumin (alpha-livetin) has been implicated as the causative allergen of Bird-Egg Syndrome. Specific bronchial challenge to Chicken albumin elicited early asthmatic responses in 6 patients with asthma. An oral challenge with Chicken albumin provoked digestive and systemic allergic symptoms in the 2 patients challenged, thus demonstrating that Chicken serum albumin may cause both respiratory and food-allergy symptoms in patients with Bird-Egg Syndrome.
Extrinsic allergic alveolitis, also known as hypersensitivity pneumonitis, Bird Fancier's Lung and Farmer's Lung, is a disease of inflammation of the lung parenchyma in the terminal bronchioles and alveoli. Symptoms may start soon after exposure to bird allergens or after many years, and may include breathlessness, cough, occasional chills, and fever. Death may also result.
The disease occurs after exposure to organic dust, especially after close contact with Chickens or other birds such as Pigeons, Budgerigars, Parrots, Canaries, Parakeets, Cockatiels, Doves or Finches. Exposure results in the development of immunoglobulin antibodies including IgE, IgM, IgA and various IgG subclasses. The antibodies may be found in the sera and saliva of patients.
The allergenic proteins may be found in bird serum, droppings, and feathers. Contact may result from handling birds, cleaning their cages, or exposure to the organic dust drifting from where the birds reside.
Diagnosis is based on a characteristic clinical picture and a typical x-ray pattern, accompanied by the presence of specific IgG antibodies.
The measurement of specific IgG using IgG tracer technology has been shown to be a sensitive and specific assay for the routine diagnostic testing of extrinsic allergic alveolitis.
A case of allergy to Chicken intestines has been reported. (Whether the reaction was due to meat allergen or serum allergens was not determined.)
Other topics
Contact urticaria from handling meat and fowl has been reported.
Other topics
In Bird-Egg Syndrome, cross-reactivity to Hen's egg occurs. IgE from patients with Bird-Egg Syndrome was shown to recognize a 70 kDa protein in egg yolk and some major allergens in bird feather extract. Chicken serum albumin is the same protein as that designated alpha-livetin in egg. The sera of patients with Bird-Egg Syndrome, pooled with Budgerigar or Hen feather extract and egg yolk extract, led to complete blocking of IgE binding to allergens in egg yolk and bird feather extract. However, IgE from patients with egg white allergy did not react with allergens in egg yolk and bird feather extract, despite strong IgE binding to egg white allergens. These results indicate common epitopes of Budgerigar and Hen feather and egg yolk alpha-livetin, and researchers suggest that alpha-livetin leads to cross-sensitization and consequently to Bird-Egg Syndrome.This adult type of egg intolerance must be distinguished from the common egg white allergy of atopic children.ELISA inhibition demonstrated only partial cross-reactivity between Chicken albumin and conalbumin.
Cross-Reactivity
Well-defined major allergenic bands with molecular mass of 20-30 kDa and 67 kDa have been detected and identified in IgE immunoblots with feather extracts as well as with serum proteins of Budgerigar, Parrot, Pigeon, Canary, and Hen. Inhalable feather dust was shown to contain several allergenic components, which cross-react with serum allergens/antigens of the same as well as of other bird species.
Cross-reactivity between Chicken and other phylogenetically related bird species may be expected, and in Chicken-allergic patients, significant IgE titers to Parrot, Budgerigar, Chicken, Pigeon, Goose and Duck have been reported, even in patients without known exposure.
References
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