Finch feathers
Clinical Relevance
IgE mediated reactions
Asthma, allergic rhinitis and allergic conjunctivitis may result following exposure to bird allergens. The allergenic proteins may be found in bird serum, droppings, skin scales, feathers and, in the case of Pigeons, Pigeon bloom (a waxy fine dust which coats the feathers of Pigeons). Contact may result from handling birds, cleaning their lofts, or exposure to the organic dust drifting down from a ceiling or roof where birds nest.
Exposure results in the development of immunoglobulins including IgE, IgM, IgA and various IgG subclasses. The antibodies may be found in the sera and saliva of patients as well as in the sera of asymptomatic but exposed subjects.
Hypersensitivity pneumonitis due to Finch feathers has been reported. Serum-precipitating antibodies to Finch extract were positive and the patient improved after removal of Finches.
Diagnosis is based on a characteristic clinical picture and a typical x-ray pattern, accompanied by the presence of specific IgG antibodies.
Other topics
Extrinsic Allergic Alveolitis, also known as Hypersensitivity pneumonitis, Bird Fancier's Lung and Farmer's Lung, is a disease of inflammation of the lung parenchyma in the terminal bronchioles and alveoli. Symptoms may start soon after exposure to bird allergens or after many years, and may include breathlessness, cough, occasional chills, and fever. Death may also result.
The disease occurs after exposure to organic dust, especially after close contact with Pigeons or other birds such as Budgerigars, Parrots, Canaries, Parakeets, Cockatiels, Doves or Finches.
References
- Tauer-Reich I, Fruhmann G, Czuppon AB, Baur X. Allergens causing bird fancier's asthma. Allergy. 1994;49(6):448-53.
- Martínez-Cordero E, Aguilar León DE, Retana VN. IgM antiavian antibodies in sera from patients with pigeon breeder's disease. Journal of clinical laboratory analysis. 2000;14(5):201-7.
- Baldwin CI, Todd A, Bourke SJ, Allen A, Calvert JE. IgG subclass responses to pigeon intestinal mucin are related to development of pigeon fanciers' lung. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1998;28(3):349-57.
- Todd A, Coan R, Allen A. Pigeon breeders' lung; IgG subclasses to pigeon intestinal mucin and IgA antigens. Clinical and experimental immunology. 1993;92(3):494-9.
- Yoshizawa Y, Miyashita Y, Inoue T, Sumi Y, Miyazaki Y, Sato T, et al. Sequential evaluation of clinical and immunological findings in hypersensitivity pneumonitis: serial subclass distribution of antibodies. Clinical immunology and immunopathology. 1994;73(3):330-7.
- McSharry C, MacLeod K, McGregor S, Speekenbrink AB, Sriram S, Boyd F, et al. Mucosal immunity in extrinsic allergic alveolitis: salivary immunoglobulins and antibody against inhaled avian antigens among pigeon breeders. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1999;29(7):957-64.
- Rodrigo MJ, Benavent MI, Cruz MJ, Rosell M, Murio C, Pascual C, et al. Detection of specific antibodies to pigeon serum and bloom antigens by enzyme linked immunosorbent assay in pigeon breeder's disease. Occupational and environmental medicine. 2000;57(3):159-64.
- Krasnick J, Patterson R, Roberts M. Multifactorial immunologic lung disease: a case report. Ann Allergy Asthma Immunol. 1995;75(3):239-41.
- Rodríguez de Castro F, Carrillo T, Castillo R, Blanco C, Díaz F, Cuevas M. Relationships between characteristics of exposure to pigeon antigens. Clinical manifestations and humoral immune response. Chest. 1993;103(4):1059-63.
