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nSus s, Pepsin, Swine

nSus s, Pepsin, Swine

nSus s, Pepsin, Swine Scientific Information
Type: Component
Name; WHO/IUIS: nSus s, Pepsin, Swine
Source Material: nSus s is purified from a swine extract
Allergen code: k213

Clinical Relevance

IgE-mediated reactions

Pepsin may uncommonly induce symptoms of occupational allergy, in particular asthma, in sensitised individuals. Safety precautions taken when using this substance may have resulted in infrequent reports of sensitisation to it. Occupational asthma was described in a 39-year-old male cheese worker, who had for 2 years experienced asthma and rhinitis elicited by work exposure to both Pepsin and Lysozyme. The presence of skin-specific IgE was demonstrated to both. One minute after Pepsin exposure, the patient developed rhinoconjunctivitis, cough, dyspnoea, wheezing, dysphonia, and glottic oedema. Lung function tests confirmed a drop in lung function. Serum-specific IgE was positive to Lysozyme but negative for Pepsin and chymosin. Occupational asthma as a result of exposure to Pepsin has been described in detergent industry workers. Occupational asthma may have an immediate, severe IgE-mediated, and a delayed, severe IgE-mediated component – the so-called dual asthmatic response, which was demonstrated in a Pepsin-hypersensitive individual following an inhalation challenge with Pepsin powder. Exogenous allergic alveolitis in workers engaged in the manufacture of Pepsin has been described.

References
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