White Mulberry
OTHER NAME(S): Chinese White Mulberry, Chi Sang, Chin Sang, Common Mulberry, Egyptian Mulberry, Mon Tea, Mora, Moral Blanco, Morera Blanca, Morin, Mûrier Blanc, Mûrier Blanc de Chine, Mûrier Commun, Mûrier du Ver à Soie, Russian Mulberry, Silkworm Mulberry, Morus alba, Morus indica, Morus multicaulis, Morera blanca, Mûrier blanc
Overview
White mulberry (Morus alba) is a shrub or tree native to China. It has a white colored fruit similar to a blackberry, but with an unpleasant taste.
Chemicals in white mulberry work similarly to some medicines used for type 2 diabetes. They slow the breakdown of sugar in the stomach so that it's absorbed more slowly into the blood. This helps the body keep blood sugar levels in a healthy range.
People commonly use white mulberry for diabetes. It is also used for high cholesterol levels, high blood pressure, the common cold, and many other conditions, but there is no good scientific evidence to support these uses.
Uses
We currently have no information for White Mulberry overview.
Side Effects
When taken by mouth: The powdered leaf of white mulberry is possibly safe for most people when taken for up to 12 weeks. It might cause bloating, constipation, gas, and loose stools in some people. There isn't enough reliable information to know if white mulberry berries are safe when taken as a medicine or what the side effects might be.
Precautions
When taken by mouth: The powdered leaf of white mulberry is possibly safe for most people when taken for up to 12 weeks. It might cause bloating, constipation, gas, and loose stools in some people. There isn't enough reliable information to know if white mulberry berries are safe when taken as a medicine or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if white mulberry is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications moved by pumps in cells (Organic cation transporter 2 (OCT2) substrates) interacts with White MulberrySome medications are moved in and out of cells by pumps. White mulberry might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
- Medications for diabetes (Antidiabetes drugs) interacts with White MulberryWhite mulberry leaf might lower blood sugar levels. Taking white mulberry leaf along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Dosing
White mulberry leaf powder or extract has most often been used by adults in doses of 0.8-1 gram three times daily for up to 3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
References
- Hwang KH, Kim YK. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Biofactors 2004;21:267-71.
- Enkhmaa B, Shiwaku K, Katsube T, et al. Mulberry (Morus alba L) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 2005;135:729-34.
- Yu Z, Fong WP, Cheng CH. The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. J Pharmacol Exp Ther 2006;316:169-75.
- Lee J, Chae K, Ha J, et al. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol 2008;115:263-70.
- Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasiuk J. In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res 2008;22:689-94.
- Moore LM. Plant Guide: White Mulberry. United States Department of Agriculture, Natural Resources Conservation Service. Available at: https://plants.usda.gov/plantguide/pdf/pg_moal.pdf. (Accessed 3 September 2009).
- Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53.
- Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4.
- Andallu B, Varadacharyulu NC. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves. J Med Food 2007;10:41-8.
- Andallu B, Varadacharyulu NC. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003;338:3-10.
- Asano N, Yamashita T, Yasuda K, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 2001;49:4208-13.
- Asano N, Oseki K, Tomioka E, et al. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res 1994;259:243-55.
- Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia 2006;77:568-73.
- Doi K, Kojima T, Makino M, et al. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull 2001;49:151-3.
- Lee SH, Choi SY, Kim H, et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull 2002;25:1045-8.
- Du J, He ZD, Jiang RW, et al. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 2003;62:1235-8.
- Park KM, You JS, Lee HY, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol 2003;84:181-5.
- El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci 2006;78:2724-33.
- Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice. Asia Pac J Clin Nutr 2007;16(Suppl 1):290-4.
- Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74.
- Oku T, Yamada M, Nakamura M, et al. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr 2006;95:933-8.
- Trimarco V, Izzo R, Stabile E, et al. Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endothelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial. High Blood Press Cardiovasc Prev 2015;22(2):149-54. doi: 10.1007/s40292-015-0087-2.
- Jung S, Lee MS, Choi AJ, Kim CT, Kim Y. Anti-Inflammatory effects of high hydrostatic pressure extract of mulberry (Morus alba) fruit on LPS-stimulated RAW264.7 cells. Molecules 2019;24(7):0. pii: E1425. doi: 10.3390/molecules24071425.
- Wattanathorn J, Somboonporn W, Sungkamanee S, Thukummee W, Muchimapura S. A double-blind placebo-controlled randomized trial evaluating the effect of polyphenol-rich herbal congee on bone turnover markers of the perimenopausal and menopausal women. Oxid Med Cell Longev 2018; 21:2018:2091872. doi: 10.1155/2018/2091872.
- Da Villa G, Ianiro G, Mangiola F, et al. White mulberry supplementation as adjuvant treatment of obesity. J Biol Regul Homeost Agents 2014;28(1):141-5.
- Gurukar MSA, Chilkunda ND. Morus alba leaf bioactives modulate peroxisome proliferator activated receptor ? in the kidney of diabetic rat and impart beneficial effect. J Agric Food Chem 2018;66(30):7923-34. doi: 10.1021/acs.jafc.8b01357.
- Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49.
- Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292.
- Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41.
- Jeong HI, Jang S, Kim KH. Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med 2022;2022:9282154.
- Taghizadeh M, Mohammad Zadeh A, Asemi Z, et al. Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial. Clin Nutr ESPEN 2022;49:68-73.
- Li R, Xue Z, Jia Y, et al. Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice. Int J Biol Macromol 2021;192:452-460.
- Wan M, Li Q, Lei Q, Zhou D, Wang S. Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile. Foods 2022;11(12):1818.