Rabdosia Rubescens
OTHER NAME(S): Bing Ling Cao, Blushred Rabdosia, Dong Ling Cao, Liu Yue Ling, Po Xue Cao, Rubescens, Sui Mi Ya, Rabdosia rubescens, Isodon rubescens, Labiatae., Rhabdosia, Rhabdosia rubescens
Overview
Rabdosia rubescens is an herb. The whole plant is used to make medicine.
People use Rabdosia rubescens for a mild form of gum disease (gingivitis), an enlarged prostate (benign prostatic hyperplasia, BPH), cancer, and other conditions, but there is no good scientific evidence to support these uses.
Developing research suggests chemicals in Rabdosia rubescens might harm cancer cells and might also keep them from multiplying.
Developing research suggests chemicals in Rabdosia rubescens might harm cancer cells and might also keep them from multiplying.
Uses
Insufficient Evidence for
- A mild form of gum disease (gingivitis). Early research shows that taking Rabdosia rubescens might reduce symptoms of gingivitis, such as red and bleeding gums.
- Cancer, including prostate cancer.
- Enlarged prostate (benign prostatic hyperplasia, BPH).
- Swelling (inflammation).
- Other conditions.
More evidence is needed to rate the effectiveness of Rabdosia rubescens for these uses.
Side Effects
When taken by mouth: There isn't enough reliable information to know if Rabdosia rubescens is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if Rabdosia rubescens is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if Rabdosia rubescens is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Rabdosia RubescensSome medications are changed and broken down by the liver. Rabdosia rubescens might increase how quickly the liver breaks down some medications. Taking Rabdosia rubescens along with some medications that are changed by the liver might decrease the effects of these medications. Before taking Rabdosia rubescens, talk to your healthcare provider if you are taking any medications that are changed by the liver. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
- Medications moved by pumps in cells (P-glycoprotein substrates) interacts with Rabdosia RubescensSome medications are moved by pumps in cells. Rabdosia rubescens might make these pumps less active and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications. Some medications that are moved by these pumps include doxorubicin, etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.
Minor Interaction
Be watchful with this combination
- Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with Rabdosia RubescensSome medications are changed and broken down by the liver. Rabdosia rubescens might increase how quickly the liver breaks down some medications. Taking Rabdosia rubescens along with some medications that are changed by the liver may decrease the effects of these medications. Before taking Rabdosia rubescens talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene), amitriptyline (Elavil), warfarin (Coumadin), glipizide (Glucotrol), losartan (Cozaar), and others.
Dosing
The appropriate dose of Rabdosia rubescens depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Rabdosia rubescens. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Liu JJ, Huang RW, Lin DJ, et al. Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. J Int Med Res 2004;32:617-25.
- Meade-Tollin LC, Wijeratne EM, Cooper D, et al. Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES. J Nat Prod 2004;67:2-4.
- Ikezoe T, Yang Y, Bandobashi, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther 2005;4:578-86.
- Chen S, Liu J, Zhang H. Efficacy of rabdosia rubescens in the treatment of gingivitis. J Huazhong Univ Sci Technolog Med Sci. 2009;29(5):659-63.
- Zhang YW, Zheng XW, Liu YJ, et al. Effect of oridonin on cytochrome P450 expression and activities in HepaRG Cell. Pharmacology. 2018;101(5-6):246-254.
- Li F, Fan J, Wu Z, et al. Reversal effects of Rabdosia rubescens extract on multidrug resistance of MCF-7/Adr cells in vitro. Pharm Biol. 2013;51(9):1196-203.
- Bi E, Liu D, Li Y, Mao X, Wang A, Wang J. Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function. Braz J Med Biol Res. 2018;51(12):e7599.
- Tian L, Xie K, Sheng D, Wan X, Zhu G. Antiangiogenic effects of oridonin. BMC Complement Altern Med. 2017;17(1):192.
- Bohanon FJ, Wang X, Ding C, et al. Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis. J Surg Res. 2014;190(1):55-63.
- Ma YC, Ke Y, Zi X, Zhao W, Shi XJ, Liu HM. Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells. Curr Cancer Drug Targets. 2013;13(6):611-24.
- Wang S, Zhong Z, Wan J, et al. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am J Chin Med. 2013;41(1):177-96.
- Jia T, Cai M, Ma X, Li M, Qiao J, Chen T. Oridonin inhibits IL-1ß-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-?. Int Immunopharmacol. 2019;69:382-388.