N-Methyltyramine
OTHER NAME(S): 4-Hydroxy-N-methylphenethylamine, Methyl-4-tyramine, N-Methyl L-tyramine, N-Methyl Tyramine, N-Methyl-tyramine, N-Methyltyramine Hydrochloride, NMT, p-(2-Methylamino)ethyl)phenol, p-(2-Methylaminoethyl)-phenol, p-(2-Methylaminoethyl)phenol, N-methyltyramine, N-Metiltiramina, N-Méthyltyramine
Overview
N-methyltyramine is a chemical that is found in bitter orange and other plants, and in the human body in small amounts. It is also made in the lab. N-methyltyramine is banned by the World Anti-Doping Agency (WADA) for use during competitive sports. N-methyltyramine is found in some dietary supplements. However, the US Food and Drug Administration (FDA) cautions against its use and is investigating whether N-methyltyramine should be allowed in dietary supplements.
N-methyltyramine is commonly used for weight loss and athletic performance, but there is no good scientific evidence to support these uses.
N-methyltyramine is most often used for weight loss. Scientists have found that chemicals that are similar to N-methyltyramine help to break down fat in fat cells. However, N-methyltyramine doesn't seem to break down fat. In fact, it might increase appetite and slow down the breakdown of fat in fat cells.
N-methyltyramine is most often used for weight loss. Scientists have found that chemicals that are similar to N-methyltyramine help to break down fat in fat cells. However, N-methyltyramine doesn't seem to break down fat. In fact, it might increase appetite and slow down the breakdown of fat in fat cells.
Uses
Insufficient Evidence for
- Athletic performance.
- Weight loss.
- Improved focus.
- Other uses.
More evidence is needed to rate the effectiveness of N-methyltyramine for these uses.
Side Effects
When taken by mouth: There isn't enough reliable information to know if N-methyltyramine is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if N-methyltyramine is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if N-methyltyramine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
High blood pressure: N-methyltyramine might increase blood pressure. In theory, taking N-methyltyramine might make high blood pressure worse.
Surgery: N-methyltyramine might increase blood pressure. In theory, taking N-methyltyramine might interfere with surgery by increasing blood pressure. Stop taking N-methyltyramine at least 2 weeks before surgery.
Interactions
Minor Interaction
Be watchful with this combination
- Medications for high blood pressure (Antihypertensive drugs) interacts with N-MethyltyramineN-methyltyramine might increase blood pressure. Taking N-methyltyramine along with medications for high blood pressure might reduce the effects of these medications. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.
- Stimulant drugs interacts with N-MethyltyramineStimulant drugs speed up the nervous system and can cause a jittery feeling and a rapid heartbeat. N-methyltyramine might also speed up the nervous system. Taking N-methyltyramine along with stimulant drugs might cause serious problems including high blood pressure. Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.
Dosing
The appropriate dose of N-methyltyramine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for N-methyltyramine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Pawar RS, Grundel E. Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs). Drug Test Anal 2017;9:500-517.
- Ni J, Guo Y, Chang N, et al. Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. Biomed Pharmacother. 2019;111:1393-1398.
- Mercader J, Wanecq E, Chen J, Carpéné C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. J Physiol Biochem. 2011;67(3):443-52.
- Kimura T, Iwasaki N, Yokoe JI, et al. Analysis and prediction of absorption profile including hepatic first-pass metabolism of N-methyltyramine, a potent stimulant of gastrin release present in beer, after oral ingestion in rats by gastrointestinal-transit-absorption model. Drug Metab Dispos. 2000;28(5):577-81.
- Koda H, Yokoo Y, Matsumoto N, et al. Antagonistic effect of N-methyltyramine on alpha2-adrenoceptor in mice. Jpn J Pharmacol. 1999;81(3):313-5.
- Leroux M, Lemery T, Boulet N, et al. Effects of the amino acid derivatives, ß-hydroxy-ß-methylbutyrate, taurine, and N-methyltyramine, on triacylglycerol breakdown in fat cells. J Physiol Biochem. 2019;75(3):263-273.
- Chang N, Li Y, Zhou M, Gao J, Hou Y, Jiang M, Bai G. The hemostatic effect study of Cirsium setosum on regulating a1-ARs via mediating norepinephrine synthesis by enzyme catalysis. Biomed Pharmacother. 2017;87:698-704.
- Könczöl Á, Rendes K, Dékány M, Müller J, Riethmüller E, Balogh GT. Blood-brain barrier specific permeability assay reveals N-methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba. J Pharm Biomed Anal. 2016;131:167-174.
- Tsutsumi E, Kanai S, Ohta M, Suwa Y, Miyasaka K. Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats. Alcohol Clin Exp Res. 2010;34 Suppl 1:S14-7.
- Zhao J, Wang M, Avula B, Khan IA. Detection and quantification of phenethylamines in sports dietary supplements by NMR approach. J Pharm Biomed Anal. 2018;151:347-355.
- U.S. Food & Drug Administration. Dietary supplement ingredient advisory list. https://www.fda.gov/food/dietary-supplement-products-ingredients/dietary-supplement-ingredient-advisory-list. Accessed September 19, 2019.
- Stohs SJ, Hartman MJ. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res. 2015;29(1):14-6.
- U.S. Anti-Doping Agency. Screen your dietary supplements. https://www.usada.org/spirit-of-sport/education/screen-dietary-supplements/. Accessed October 22, 2019.