Magnolia
OTHER NAME(S): Beaver Tree, Bourgeon Floral de Magnolia, Chuan Houpu, Cortex Magnoliae Officinalis, Flos Magnoliae, Holly Bay, Ho-No-Ki, Hou Po, Hou Po Hua, Houpohua, Houpo, Houpu, Indian Bark, Japanese Whitebark Magnolia, Koboku, Magnolia Bark, Magnolia Flower Bud, Magnolia Rouge, Red Bay, Red Magnolia, Swamp Laurel, Swamp Sassafras, Sweet Bay, Tuhoupu, White Bay, White Laurel, Xin Ye Hua, Xin Yi Hua, Xinyi, Xinyihua, Magnolia biondii, Magnolia fargesii, Magnolia denudata, Magnolia conspicua, Magnolia yulan, Magnolia heptaperta, Magnolia virginiana, Magnolia glauca, Magnolia obovata, Magnolia hypoleuca, Magnolia officinalis, Magnolia sprengeri, Magnolia sargentiana, Magnolia emargenata, Magnolia wilsonii, Magnolia nicholsoniana, Magnolia taliensis, Magnolia salicifolia, Buergeria salicifolia, Magnolia proctoriana, other Magnolia species.r Family: Magnoliaceae., Cortex Magnoliae O.
Overview
Magnolia (Magnolia biondii) is a plant found in parts of Asia and North and South America. The bark and flowers are used in Traditional Chinese Medicine.
Magnolia seems to have anxiety-reducing effects. Chemicals in magnolia might kill bacteria in the mouth which might help prevent cavities or reduce gum swelling.
In Traditional Chinese Medicine, magnolia is used to treat the "stagnation of qi" as well as for depression and anxiety. People also use magnolia for obesity, stress, gingivitis, plaque, and other conditions, but there is no good scientific evidence to support most of these uses.
Uses
Possibly Effective for
- A mild form of gum disease (gingivitis). Chewing gum or using a toothpaste containing magnolia extract seems to reduce the swelling and bleeding of gums.
There is interest in using magnolia for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When taken by mouth: Magnolia extract is possibly safe for most people when used for up to 6 weeks.
When used in toothpaste: Magnolia is possibly safe for most people when used for up to 6 months.
When applied to the skin: There isn't enough reliable information to know if magnolia is safe. Some people may develop skin rashes when magnolia is applied to the skin.
Precautions
When taken by mouth: Magnolia extract is possibly safe for most people when used for up to 6 weeks.
When used in toothpaste: Magnolia is possibly safe for most people when used for up to 6 months.
When applied to the skin: There isn't enough reliable information to know if magnolia is safe. Some people may develop skin rashes when magnolia is applied to the skin.
Pregnancy: Taking magnolia flower bud by mouth is unsafe during pregnancy. Magnolia might cause the uterus to contract, which could cause a miscarriage. There isn't enough reliable information to know if magnolia bark is safe to use during pregnancy. Stay on the safe side and avoid use.
Breast-feeding: There isn't enough reliable information to know if magnolia is safe to use when breast-feeding. Stay on the safe side and avoid use.
Surgery: There's a concern that magnolia might slow down the nervous system too much when combined with anesthesia and other medications used during and after surgery. Magnolia might also slow blood clotting and cause bleeding during and after surgery. Stop using magnolia at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Sedative medications (CNS depressants) interacts with MagnoliaMagnolia might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking magnolia with sedative medications might cause breathing problems and/or too much sleepiness.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with MagnoliaMagnolia might slow blood clotting. Taking magnolia along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Dosing
Magnolia is used in toothpastes, chewing gum, and dietary supplements. There isn't enough reliable information to know what an appropriate dose of magnolia might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Wang SM, Lee LJ, Huang YT, et al. Magnolol stimulates steroidogenesis in rat adrenal cells. Br J Pharmacol 2000;131:1172-8.
- Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9.
- Maruyama Y, Kuribara H, Kishi E, et al. Confirmation of the anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments. J Pharm Pharmacol 2001;53:721-5.
- Kuribara H, Kishi E, Maruyama Y. Does dihydrohonokiol, a potent anxiolytic compound, result in the development of benzodiazepine-like side effects? J Pharm Pharmacol 2000;52:1017-22.
- Zhong WB, Wang CY, Ho KJ, et al. Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation. Anticancer Drugs 2003;14:211-7.
- Nakazawa T, Yasuda T, Ohsawa K. Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice. J Pharm Pharmacol 2003;55:1583-91.
- Hou YC, Chao PD, Chen SY. Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats. Am J Chin Med 2000;28:379-84.
- Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40.
- Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
- Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
- Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65.
- Kalman, D. S., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D. R., and Garrison, R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11.
- Campus G, Cagetti MG, Cocco F, Sale S, Sacco G, Strohmenger L, Lingström P. Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial. Caries Res. 2011;45(4):393-9.
- Feng WS, He YH, Zheng XK, Wang JC, Cao YG, Zhang YL, Song K. Four New Monoterpenoid Glycosides from the Flower Buds of Magnolia biondii. Molecules. 2016 Jun 3;21(6). pii: E728.
- Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
- Hellström MK, Ramberg P. The effect of a dentifrice containing Magnolia extract on established plaque and gingivitis in man: a six-month clinical study. Int J Dent Hyg. 2014 May;12(2):96-102.
- Porciani PF, Grandini S. The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity. J Clin Dent. 2012;23(3):76-9.
- Porciani PF, Grandini S, Chazine M. The effect of zinc lactate and magnolia bark extract added tablets on volatile sulfur-containing compounds in the oral cavity. J Clin Dent. 2014;25(3):53-6.
- Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
- Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013;10(1):37.
- Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
- De Franciscis P, Grauso F, Luisi A, Schettino MT, Torella M, Colacurci N. Adding Agnus Castus and Magnolia to Soy Isoflavones Relieves Sleep Disturbances Besides Postmenopausal Vasomotor Symptoms-Long Term Safety and Effectiveness. Nutrients. 2017;9(2):129.
- Yimam M, Jiao P, Hong M, et al. UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss. BMC Complement Altern Med. 2017;17(1):114.
- Schifano F, Guarino V, Papanti DG, Baccarin J, Orsolini L, Corkery JM. Is there a potential of misuse for Magnolia officinalis compounds/metabolites? Hum Psychopharmacol Clin Exp. 2017;32:e2595.
- Poivre M, Duez P. Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J Zhejiang Univ Sci B. 2017;18(3):194-214.
- Xue L, Zhang J, Shen H, Ai L, Wu R. A randomized controlled pilot study of the effectiveness of magnolia tea on alleviating depression in postnatal women. Food Sci Nutr. 2020;8(3):1554-1561.
- Maffei S, Franchini M, Fortunato L, Guiducci L. Long-term effects of a combination of isoflavones, agnus castus and magnolia extracts on climacteric symptoms and cardiometabolic risk profile in postmenopausal women. Gynecol Endocrinol 2022;38(4):339-344.
- Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.