Lathyrus

OTHER NAME(S): Caley Pea, Chícharo Hirsuto, Chickling Pea, Chickling Vetch, Chick-Pea, Doncenón, Everlasting Pea, Flat-Podded Vetch, Gesse, Gesse Articulée, Gesse des Bois, Gesse Clymène, Gesse Commune, Gesse Chiche, Gesse Hérissée, Gesse Sauvage, Gesse Tubéreuse, Guisante de Olor, Jarosse, Pois Carré, Pois de Senteur, Singletary Pea, Spanish Vetchling, Sweet Pea, Wild Pea, Lathyrus cicera, Lathyrus clymenum, Lathyrus hirsutus, Lathyrus incanus, Lathyrus odoratus, Lathyrus pusillus, Lathyrus sativus, Lathyrus sylvestris, Guisante De Olor

Overview

Lathyrus is a plant. People use it as medicine.

Despite serious safety concerns, Lathyrus sativus is used in unleavened Indian bread. Lathyrus seeds are eaten as food and used as animal fodder throughout the world.

The flowers of sweet pea (Lathyrus odoratus) are grown for their color and fragrance.

There isn't enough information to know how lathyrus might work for any medical use.

There isn't enough information to know how lathyrus might work for any medical use.

References
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab Rev 1999;31(3):561-587.
  3. Porcel, S., Leon, F., Valero, A. M., Calderin, P. M., Cuevas, M., and Cuesta, E. A. Occupational rhinitis and asthma by Lathyrus sativus flour: characterization of allergens. J.Allergy Clin.Immunol. 2001;107(4):743-744.
  4. Ravindranath, V. Neurolathyrism: mitochondrial dysfunction in excitotoxicity mediated by L-beta-oxalyl aminoalanine. Neurochem.Int 2002;40(6):505-509.
  5. Drory, V. E., Rabey, M. J., and Cohn, D. F. Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol.Scand 1992;85(6):401-403.
  6. Krogsgaard-Larsen, P. and Hansen, J. J. Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design. Toxicol Lett 1992;64-65 Spec No:409-416.
  7. Getahun, H., Lambein, F., Vanhoorne, M., and Van der, Stuyft P. Food-aid cereals to reduce neurolathyrism related to grass-pea preparations during famine. Lancet 11-29-2003;362(9398):1808-1810.
  8. Pratap Rudra, M. P., Singh, M. R., Junaid, M. A., Jyothi, P., and Rao, S. L. Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism. Clin Biochem 2004;37(4):318-322.
  9. Warren, B. A., Patel, S. A., Nunn, P. B., and Bridges, R. J. The Lathyrus excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid is a substrate of the L-cystine/L-glutamate exchanger system xc-. Toxicol Appl Pharmacol 10-15-2004;200(2):83-92.
  10. Yan, Z. Y., Spencer, P. S., Li, Z. X., Liang, Y. M., Wang, Y. F., Wang, C. Y., and Li, F. M. Lathyrus sativus (grass pea) and its neurotoxin ODAP. Phytochemistry 2006;67(2):107-121.
  11. Anton, Girones M., de la Hoz, Caballer B., Munoz, Martin T., Cuevas, Agustin M., and Sanchez-Cano, M. Occupational rhinoconjunctivitis and asthma by exposure to Lathyrus sativus flour. Allergol.Immunopathol.(Madr.) 2005;33(6):326-328.
  12. Haimanot, R. T., Kidane, Y., Wuhib, E., Kalissa, A., Alemu, T., Zein, Z. A., and Spencer, P. S. Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. Int J Epidemiol. 1990;19(3):664-672.
  13. Spencer, P. S., Roy, D. N., Ludolph, A., Hugon, J., Dwivedi, M. P., and Schaumburg, H. H. Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 11-8-1986;2(8515):1066-1067.
  14. Valdivieso, R., Quirce, S., and Sainz, T. Bronchial asthma caused by Lathyrus sativus flour. Allergy 1988;43(7):536-539.
  15. Ludolph, A. C., Hugon, J., Dwivedi, M. P., Schaumburg, H. H., and Spencer, P. S. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain 1987;110 ( Pt 1):149-165.
  16. Striefler, M., Cohn, D. F., Hirano, A., and Schujman, E. The central nervous system in a case of neurolathyrism. Neurology 1977;27(12):1176-1178.
  17. Spencer, P. S. and Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav.Toxicol Teratol. 1983;5(6):625-629.
  18. Cohn, D. F. and Streifler, M. Intoxication by the chickling pea (Lathyrus sativus): nervous system and skeletal findings. Arch.Toxicol.Suppl 1983;6:190-193.
  19. Weintroub, S., Cohen, D. F., Salama, R., Streifler, M., and Weissman, S. L. Skeletal findings in human neutrolethyrism. Is there a human osteolathyrism? Eur Neurol. 1980;19(2):121-127.
  20. Lieberman, P. Preventing fatalities from anaphylaxis: an allergist-immunologist's perspective. Allergy Proc 1995;16(3):109-111.
  21. Lambein, F., Haque, R., Khan, J. K., Kebede, N., and Kuo, Y. H. From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism. Toxicon 1994;32(4):461-466.
  22. Hugon, J., Ludolph, A. C., Spencer, P. S., Gimenez, Roldan S., and Dumas, J. L. Studies of the etiology and pathogenesis of motor neuron diseases. III. Magnetic cortical stimulation in patients with lathyrism. Acta Neurol.Scand 1993;88(6):412-416.
  23. Haimanot, R. T., Kidane, Y., Wuhib, E., Kassina, A., Endeshaw, Y., Alemu, T., and Spencer, P. S. The epidemiology of lathyrism in north and central Ethiopia. Ethiop.Med J 1993;31(1):15-24.
  24. Misra, U. K., Sharma, V. P., and Singh, V. P. Clinical aspects of neurolathyrism in Unnao, India. Paraplegia 1993;31(4):249-254.
  25. Haque, A., Hossain, M., Lambein, F., and Bell, E. A. Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh. Nat Toxins. 1997;5(1):43-46.
  26. Durlach, J., Bac, P., Durlach, V., Durlach, A., Bara, M., and Guiet-Bara, A. Are age-related neurodegenerative diseases linked with various types of magnesium depletion? Magnes.Res 1997;10(4):339-353.
  27. Grela Eugeniusz, R., Studzinski, T., and Winiarska, A. Lathyrism in people and animals . Publication of the Polish Society of Veterinary Sciences 2000;56(9):558-562.
  28. Malaguarnera, M., Vacante, M., Motta, M., Giordano, M., Malaguarnera, G., Bella, R., Nunnari, G., Rampello, L., and Pennisi, G. Acetyl-L-carnitine improves cognitive functions in severe hepatic encephalopathy: a randomized and controlled clinical trial. Metab Brain Dis 2011;26(4):281-289.