Lacticaseibacillus Paracasei
OTHER NAME(S): L. paracasei, Lacticaseibacillus paracasei, Lactobacillus paracasei
Overview
Lacticaseibacillus paracasei (L. paracasei) is a probiotic bacteria that is available over the counter as a supplement and in some fermented foods. It is commonly used for allergies and to improve the health of the gut and mouth, but its benefits are not well defined. Common side effects include gas and an upset stomach. Serious side effects are rare and include infections in some people who are at high risk of infections. Before taking L. paracasei, make sure to tell your health care provider about any health conditions you have or medicines you are taking.
Uses
What is Lacticaseibacillus paracasei (L. paracasei) used for?
L. paracasei is a probiotic that is commonly used to improve overall health, as well as the health of the gut and mouth. It is also sometimes used for allergy symptoms. However, its benefits for any use are not well defined.
L. paracasei is available as a dietary supplement in various strengths and dosage forms. Some dietary supplements that contain L. paracasei also contain many other ingredients, including other probiotics.
Note: The FDA has not reviewed L. paracasei for safety and effectiveness. Learn more about dietary supplements here.
How does L. paracasei work (mechanism of action)?
L. paracasei is a species of bacteria. It is a type of probiotic, which means it is a live microbe that may provide health benefits in some people.
Your body is home to millions of different microbes, which make up part of your microbiome. L. paracasei is naturally found in your gut. You can also get L. paracasei from dietary supplements and some fermented foods, such as kefir, yogurt, sauerkraut, and kimchi.
L. paracasei makes a substance called lactic acid. Lactic acid can help improve the health of your microbiome by reducing the amount of bad bacteria and increasing the amount of good bacteria. When the microbiome in your gut is healthy, this can make you more able to digest foods and resist infections. It could also help to reduce the risk of conditions that are caused by an overactive immune system, such as allergies and atopic dermatitis (eczema).
Taking L. paracasei by mouth increases the levels of this bacteria in your gut. This may help improve the health of your microbiome. But there are many factors that can affect whether a probiotic survives in your body. When you take L. paracasei by mouth, it may not always survive long enough to grow and multiply in your gut. As a result, its benefits are not well defined and may be different for each person. It is not clear whether L. paracasei can help with any health problems.
How should I store L. paracasei?
You should store L. paracasei according to the product label. Most dietary supplements should be kept in a cool, dry location that is out of the reach of children and pets and not in direct sunlight.
Side Effects
What are the most common side effects of L. paracasei?
The most common side effects of L. paracasei are listed below. These side effects may vary depending on the dose you are taking or the specific product you are using. Tell your health care provider if you have any of these side effects that bother you.
- Gas
- Upset stomach
There may be other side effects of L. paracasei that are not listed here. Contact your health care provider if you think you are having a side effect of a supplement. In the U.S., you can report side effects to the FDA at www.safetyreporting.hhs.gov or by calling 888-SAFEFOOD (888-723-3366). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of L. paracasei?
While less common, the most serious side effects of L. paracasei are described below, along with what to do if they happen.
Severe Allergic Reactions. L. paracasei may cause allergic reactions, which can be serious. Stop taking L. paracasei and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching or skin rash
- Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Serious Infections. In very rare cases, some people who take probiotics, such as L. paracasei, can get a serious infection. This happens when L. paracasei moves into a part of the body where it is not supposed to be, such as your blood. This is most likely to happen in people who are very sick or who have very weak immune systems, such as people with cancer or those receiving chemotherapy. Call your health care provider right away if you have any of the following symptoms.
- Fever, sweats, chills, or muscle aches
- Tiredness
- Shortness of breath
- Fast heartbeat
Precautions
Who should not use L. paracasei?
Allergies to Ingredients. People who are allergic to any of the following should not take L. paracasei.
- L. paracasei
- Lacticaseibacillus paracasei
- Lactobacillus paracasei
- Any of the ingredients in the specific product
Your pharmacist can tell you all of the ingredients in the specific L. paracasei products they stock.
What should I know about L. paracasei before using it?
L. paracasei is a dietary supplement. It cannot be marketed to treat or cure a disease.
Read and follow the directions on the specific product you are taking, or take it as recommended by your health care provider.
Keep L. paracasei out of the reach of children.
Premature infants can be at greater risk of side effects from probiotics, such as L. paracasei. Talk to your health care provider about the risks if your infant was born prematurely.
The full name for L. paracasei, Lacticaseibacillus paracasei, has only been around since 2020. Before that, this species of bacteria was called Lactobacillus paracasei. You may still see both of these names on product labels. These are the same species of bacteria.
Probiotics, such as L. paracasei, are usually measured in colony-forming units (CFUs). Each CFU is equal to one living bacteria. The number of CFUs listed on the product label tells you how many living bacteria should be in that product on the day it expires. Since bacteria slowly die off over time, the number of living bacteria in the product may be higher than the amount on the label.
Many probiotic products contain multiple species of microbes. Different microbes can have different effects in the body. It is important to read the product label closely to understand which species of bacteria are in that product.
L. paracasei is a species of bacteria. Within that species are many different strains. Each strain of L. paracasei may have slightly different effects in the body. This means that some strains of L. paracasei may have certain effects that other strains do not have. If the product you are using contains a specific strain, it should be listed on the product label as the string of numbers or letters that come after “L. paracasei.” If you switch to a different strain of L. paracasei, it may not have the same effects or side effects. Talk to your health care provider if you have questions or concerns.
Some probiotic products have been found to contain other microbes that are not listed on the label, which may cause serious health problems. The FDA has not tested L. paracasei products to confirm that they contain the ingredients stated on their labels. Some dietary supplements have been tested by third-party organizations to confirm that they contain the ingredients listed on their labels and do not contain any harmful chemicals. Learn more about how to choose a safe dietary supplement product here.
What should I tell my health care provider before using L. paracasei?
Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if L. paracasei is right for you.
In particular, make sure that you discuss any of the following.
Central Line or Port.A central venous catheter (central line) or port is a small tube placed into a vein that can be used to give medicines and fluids directly into the vein (intravenously, or IV). These tubes can become infected by microbes, including probiotics. If you have a central line or port, speak with your health care provider before taking L. paracasei.
Other Current and Past Health Conditions.Tell your health care provider if you have any of the following.
- An autoimmune condition
- Cancer
- Immune problems, such as a weak immune system
Other Medicines and Supplements.L. paracasei may interact with other medicines and supplements. Before taking L. paracasei, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how L. paracasei could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.
Breastfeeding. It is not known if L. paracasei passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.
Interactions
Does L. paracasei interact with foods or drinks?
There are no known interactions between L. paracasei and foods or drinks.
It is unknown if drinking alcohol will affect L. paracasei.
Does L. paracasei interact with medicines (drug interactions)?
Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking L. paracasei.
- A medicine that suppresses the immune system
- An antibiotic, which is used to treat certain bacterial infections
- Chemotherapy, which is used to treat certain cancers
The interactions between L. paracasei and medicines are not fully understood. As with most dietary supplements, the research on drug interactions with L. paracasei is incomplete. Always check with your health care provider before taking L. paracasei with any medicines.
Dosing
What should I do if I accidentally use too much L. paracasei?
If you or someone else has used too much L. paracasei, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
L. paracasei products may contain many different ingredients, including other probiotics. Read the product label closely and speak to a health care provider about how to take L. paracasei safely. Do not take double or extra doses, even if you miss a dose.
References
- BMC Oral Health: “The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: A randomized, double-blind, crossover, placebo-controlled trial.”
- Brain, Behavior, & Immunity - Health: “Efficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress: a randomized, triple-blind, placebo-controlled clinical trial (the ChillEx study).”
- Cells: “Lacticaseibacillus paracasei GM-080 ameliorates allergic airway inflammation in children with allergic rhinitis: From an animal model to a double-blind, randomized, placebo-controlled trial.”
- The Journal of Nutrition: “Effect of daily consumption of a fermented milk containing Lacticaseibacillus paracasei strain Shirota (LcS) on stool consistency in United States adults with hard or lumpy stools: A randomized controlled trial.”
- National Center for Complementary and Integrative Health: “5 Things To Know About Probiotics,” “Probiotics: Usefulness and Safety.”
- National Institutes of Health Office of Dietary Supplements: “Probiotics Fact Sheet for Consumers,” “Probiotics Fact Sheet for Health Professionals.”
- Nature Reviews Gastroenterology & Hepatology: “The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods.”
- Neurobiology of Stress: “Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study).”
- Nutrients: “Plant-derived Lactobacillus paracasei IJH-SONE68 improves chronic allergy status: A randomized, double-blind, placebo-controlled clinical trial.”
- Pediatrics & Neonatology: “Evaluation of the effect of Lactobacillus paracasei (HF.A00232) in children (6-13 years old) with perennial allergic rhinitis: A 12-week, double-blind, randomized, placebo-controlled study.”
- FDA: “FDA Raises Concerns About Probiotic Products Sold for Use in Hospitalized Preterm Infants.”