Kinetin
OTHER NAME(S): 6-Furfurylaminopurine, 9-(b-D-Ribofuranosyl)-6-furfurylaminopurine, Cinetina, K, Kinerase, Kinetase, Kinetin Riboside, Kinetina, Kn, N-(2-furanylmethyl)-1H-purin-6-amine, N(u003Cnorefu003E6u003C/norefu003E)furfuryladenine, N6-furfuryladenine, Quinetina, Kinetin, Kinetina (Cinetina), Kinétine
Overview
Kinetin is a cytokinin. Cytokinins are compounds that stimulate plants to grow. Kinetin occurs naturally in humans and is sometimes used to make medicine.
People use kinetin most often for aging skin, skinwrinkles from sun damage, and a skin condition that causes redness on the face (rosacea), but there is no good scientific evidence to support these uses.
Kinetin prevents green plant leaves from turning brown. There is some information that suggests kinetin might prevent age-related changes in human skin by protecting the DNA in skin cells from damage (antioxidant effects) and decreasing skin water loss.
Kinetin prevents green plant leaves from turning brown. There is some information that suggests kinetin might prevent age-related changes in human skin by protecting the DNA in skin cells from damage (antioxidant effects) and decreasing skin water loss.
Uses
Insufficient Evidence for
- A skin condition that causes redness on the face (rosacea). Early research shows that applying a lotion containing kinetin helps to reduce most symptoms of rosacea, like roughness and redness, in most people. But it doesn't seem to help everyone.
- Skin wrinkles from sun damage. Early research shows that applying a lotion containing kinetin to the face helps to reduce wrinkles and to improve the feeling of the skin in people who have wrinkled skin from the sun.
- Aging skin.
- An inner ear disorder marked by dizziness, hearing loss, and ringing in the ear (Meniere disease).
- Skin imperfections.
- Other conditions.
More evidence is needed to rate the effectiveness of kinetin for these uses.
Side Effects
When taken by mouth: There isn't enough reliable information to know if kinetin is safe. It might cause side effects such as nausea, headache, diarrhea, rash, and ringing in the ears.
When applied to the skin: Kinetin is POSSIBLY SAFE when used in a cream or lotion containing kinetin 0.1% for up to 12 weeks. It might cause side effects such as redness, dryness, peeling, burning, stinging, and itching in some people. But it isn't clear if these symptoms are from kinetin or another ingredient in the products used.
When applied into the ear: There isn't enough reliable information to know if kinetin is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if kinetin is safe. It might cause side effects such as nausea, headache, diarrhea, rash, and ringing in the ears.
When applied to the skin: Kinetin is POSSIBLY SAFE when used in a cream or lotion containing kinetin 0.1% for up to 12 weeks. It might cause side effects such as redness, dryness, peeling, burning, stinging, and itching in some people. But it isn't clear if these symptoms are from kinetin or another ingredient in the products used.
When applied into the ear: There isn't enough reliable information to know if kinetin is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if kinetin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Bleeding disorders: There is some concern that kinetin might prolong bleeding time and increase the risk of bruising and bleeding in some people with bleeding disorders. If you have a bleeding disorder, use kinetin with caution.
Surgery: Kinetin might increase the risk of bleeding during and after surgery. Stop taking kinetin at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with KinetinKinetin might slow blood clotting in some people. Taking kinetin along with medications that also slow clotting might increase the chances of bruising and bleeding in some people. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Dosing
The appropriate dose of kinetin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for kinetin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Olsen A, Siboska GE, Clark BF, Rattan SI. N(6)-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem Biophys Res Commun 1999;265:499-502.
- Bruneton J. Pharmacognosy Phytochemistry Medicinal Plants. 2nd ed. Paris, FR: Lavoisier, 1999:142.
- Rattan SI, Clark BF. Kinetin delays onset of aging characteristics in human fibroblasts. Biochem Biophys Res Commun 1994;201:665-72.
- Barciszewski, J., Mielcarek, M., Stobiecki, M., Siboska, G., and Clark, B. F. Identification of 6-furfuryladenine (kinetin) in human urine. Biochem Biophys Res Commun. 12-9-2000;279(1):69-73.
- Hsiao, G., Shen, M. Y., Lin, K. H., Chou, C. Y., Tzu, N. H., Lin, C. H., Chou, D. S., Chen, T. F., and Sheu, J. R. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol 4-4-2003;465(3):281-287.
- Adunka, O., Moustaklis, E., Weber, A., May, A., von Ilberg, C., Gstoettner, W., and Kierner, A. C. Labyrinth anesthesia--a forgotten but practical treatment option in Meniere's disease. ORL J Otorhinolaryngol.Relat Spec. 2003;65(2):84-90.
- Sheu, J. R., Hsiao, G., Shen, M. Y., Chou, C. Y., Lin, C. H., Chen, T. F., and Chou, D. S. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. Platelets. 2003;14(3):189-196.
- Griffaut, B., Bos, R., Maurizis, J. C., Madelmont, J. C., and Ledoigt, G. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004;34(4):271-275.
- Hessemer, V., Hoppe, O., and Jacobi, K. W. [Effect of hyaluronidase on ocular circulatory changes caused by retrobulbar anesthesia]. Fortschr Ophthalmol. 1991;88(2):196-200.
- Krohn, J., Seland, J. H., Hovding, G., Bertelsen, T., Aasved, H., and Haugen, O. H. Retrobulbar anesthesia with and without hyaluronidase in extracapsular cataract surgery. A prospective, randomized, double-blind study. Acta Ophthalmol.(Copenh) 1993;71(6):791-795.
- Barciszewski, J., Siboska, G. E., Pedersen, B. O., Clark, B. F., and Rattan, S. I. Evidence for the presence of kinetin in DNA and cell extracts. FEBS Lett 9-16-1996;393(2-3):197-200.
- Baum C, Bohnen S, Sill B, et al. Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support. Int J Cardiol. 2015;181:176-8.
- Orr AL, Rutaganira FU, de Roulet D, et al. Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017;109:106-116.
- Jablońska-Trypuć A, Matejczyk M, Czerpak R. N6-benzyladenine and kinetin influence antioxidative stress parameters in human skin fibroblasts. Mol Cell Biochem. 2016;413(1-2):97-107.
- Wanitphakdeedecha R, Meeprathom W, Manuskiatti W. Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian J Dermatol Venereol Leprol. 2015;81(5):547.
- Pros E, Fernández-Rodríguez J, Benito L, et al. Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment. Eur J Hum Genet. 2010;18(5):614-7.
- Gold-von Simson G, Goldberg JD, Rolnitzky LM, et al. Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res. 2009;65(3):341-6.
- Berge U, Kristensen P, Rattan SIS. Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro. Ann N Y Acad Sci. 2006;1067:332-6.
- Dudzik P, Dulińska-Litewka J, Wyszko E, et al. Effects of kinetin riboside on proliferation and proapoptotic activities in human normal and cancer cell lines. J Cell Biochem. 2011;112(8):2115-24.
- Chiu PC, Chan CC, Lin HM, Chiu HC. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol. 2007;6(4):243-9.
- Wu JJ, Weinstein GD, Kricorian GJ, Kormeili T, McCullough JL. Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea. Clin Exp Dermatol. 2007;32(6):693-5.