Japanese Persimmon
OTHER NAME(S): Caqui, Chinese Persimmon, Chinese Plum, Coing de Chine, Diospyroskaki, Dried Persimmon, Figuier Caque, Fuyu, Hachiya, Hachiya Persimmon, Hanagosho, Jiro, Kaki, Kaki du Japon, Kaki Persimmon, Korean Persimmon, Oriental Persimmon, Persimmon, Persimmon Fruit, Persimmon Japonais, Persimmon Juice, Persimmon Punch, Plaqueminier, Plaqueminier de Chine, Plaqueminier du Japon, Plaqueminier Kaki, Sharon Fruit, Diospyros kaki, Diospyros chinensis, Caqui Japonés, Plaqueminier Du Japon
Overview
Japanese persimmon is a tree. People eat the fruit. The fruit and leaf are used for medicine.
Japanese persimmon is used for high blood pressure, fluid retention, constipation, and other conditions, but there is no good scientific evidence to support many of these uses.
Japanese persimmon contains chemicals that might lower blood pressure. There isn't enough information to know how Japanese persimmon works for other conditions.
Japanese persimmon contains chemicals that might lower blood pressure. There isn't enough information to know how Japanese persimmon works for other conditions.
Uses
Insufficient Evidence for
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Early research shows that eating fiber from unripe Japanese persimmon fruit may lower lipid levels in the blood.
- Prediabetes. Early research in people with prediabetes shows that taking Japanese persimmon leaf extract might lower blood sugar.
- Constipation.
- Fluid retention.
- Hiccough.
- High blood pressure.
- Improving blood flow.
- Reducing body temperature.
- Stroke.
- Other conditions.
More evidence is needed to rate Japanese persimmon for these uses.
Side Effects
When taken by mouth: Japanese persimmon is POSSIBLY SAFE when taken as a medicine. It has been used in clinical research without reported adverse effects. The fruit might cause allergic reactions in some people, but this is uncommon. Eating the fruit in very large amounts might cause blockage of the intestines.
Precautions
When taken by mouth: Japanese persimmon is POSSIBLY SAFE when taken as a medicine. It has been used in clinical research without reported adverse effects. The fruit might cause allergic reactions in some people, but this is uncommon. Eating the fruit in very large amounts might cause blockage of the intestines.
Pregnancy and breast-feeding: Not enough is known about the use of Japanese persimmon during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Bleeding disorders: Taking Japanese persimmon might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.
Low blood pressure: Japanese persimmon might lower blood pressure. There is some concern that it might make low blood pressure worse or interfere with treatment intended to raise low blood pressure.
Surgery: Japanese persimmon might lower blood pressure or slow blood clotting. This might interfere with blood pressure control or increase the chance of excessive bleeding during and after surgery. Stop using Japanese persimmon at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for high blood pressure (Antihypertensive drugs) interacts with Japanese PersimmonJapanese persimmon seems to decrease blood pressure. Taking Japanese persimmon along with medications for high blood pressure might cause your blood pressure to go too low. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Japanese PersimmonJapanese persimmon might slow blood clotting. Taking Japanese persimmon along with medications that also slow clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others.
Dosing
The appropriate dose of Japanese persimmon depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Japanese persimmon. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Yin MH, Kang DG, Choi DH, et al. Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines. J Ethnopharmacol 2005;99:113-7..
- Han J, Kang S, Choue R, et al. Free radical scavenging effect of Diospyros kaki, Laminaria japonica and Undaria pinnatifida. Fitoterapia 2002;73:710-2..
- Duan J, Wang X, Dong Q, et al. Structural features of a pectic arabinogalactan with immunological activity from the leaves of Diospyros kaki. Carbohydr Res 2003;338:1291-7..
- Matsumoto M, Kotani M, Fujita A, et al. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br J Dermatol 2002;146:221-7. .
- Hibino G, Nadamoto T, Fujisawa F, Fushiki T. Regulation of the peripheral body temperature by foods: a temperature decrease induced by the Japanese persimmon (kaki, Diospyros kaki). Biosci Biotechnol Biochem 2003;67:23-8. .
- Kawase M, Motohashi N, Satoh K, et al. Biological activity of persimmon (Diospyros kaki) peel extracts. Phytother Res 2003;17:495-500. .
- Anliker MD, Reindl J, Vieths S, Wuthrich B. Allergy caused by ingestion of persimmon (Diospyros kaki): detection of specific IgE and cross-reactivity to profilin and carbohydrate determinants. J Allergy Clin Immunol 2001;107:718-23.
- Martinez JC, Armentia A, Bartolome B, et al. Anaphylaxis after ingestion of Sharon fruit. Allergol Immunoplathol (Madr) 2001;29:69-71.
- Akdoğan RA, Türkyilmaz S, Sipahi T, Uzun DY, Ozgür O. Gastric outlet syndrome caused by persimmon (Diospyros kaki) bezoars. Turk J Gastroenterol. 2009;20(1):72-4.
- An BJ, Kwak JH, Park JM, et al. Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin. Dermatol Surg. 2005;31(7 Pt 2):848-54; discussion 854.
- Gato N, Kadowaki A, Hashimoto N, Yokoyama S, Matsumoto K. Persimmon fruit tannin-rich fiber reduces cholesterol levels in humans. Ann Nutr Metab. 2013;62(1):1-6.
- Hwang YH, Ha H, Kim R, et al. Anti-Osteoporotic Effects of Polysaccharides Isolated from Persimmon Leaves via Osteoclastogenesis Inhibition. Nutrients. 2018;10(7). pii: E901.
- Kazzem M, Sun YT, Low M, et al. Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves. Molecules. 2019;24(6). pii: E1101.
- Khan MM, Tran BQ, Jang YJ, et al. Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects. Mol Cells. 2017;40(7):466-475.
- Kim HH, Kim DS, Kim SW, et al. Inhibitory effects of Diospyros kaki in a model of allergic inflammation: role of cAMP, calcium and nuclear factor-κB. Int J Mol Med. 2013;32(4):945-51.
- Kim KA, Kang SW, Ahn HR, Song Y, Yang SJ, Jung SH. Leaves of Persimmon (Diospyros kaki Thunb.) Ameliorate N-Methyl-N-nitrosourea (MNU)-Induced Retinal Degeneration in Mice. J Agric Food Chem. 2015;63(35):7750-9.
- Lee YA, Cho EJ, Yokozawa T. Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence. Biol Pharm Bull. 2008;31(6):1265-9.
- Ma Y, Ma B, Shang Y, et al. Flavonoid-rich ethanol extract from the leaves of Diospyros kaki attenuates cognitive deficits, amyloid-beta production, oxidative stress, and neuroinflammation in APP/PS1 transgenic mice. Brain Res. 2018;1678:85-93.
- Sa YS, Kim SJ, Choi HS. The anticoagulant fraction from the leaves of Diospyros kaki L. has an antithrombotic activity. Arch Pharm Res. 2005;28(6):667-74.
- Ueda K, Kawabata R, Irie T, Nakai Y, Tohya Y, Sakaguchi T. Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses. PLoS One. 2013;8(1):e55343.
- Yamagata Y, Saito K, Hirano K, et al. Obstruction in the third portion of the duodenum due to a diospyrobezoar: a case report. BMC Surg. 2017;17(1):117.
- Yang SJ, Jo H, Kim KA, et al. Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization. J Med Food. 2016;19(1):106-9.
- Zhou Z, Huang Y, Liang J, Ou M, Chen J, Li G. Extraction, purification and anti-radiation activity of persimmon tannin from Diospyros kaki L.f. J Environ Radioact. 2016;162-163:182-188.
- Song M, Yang G, Hoa TQ, et al. Anti-obesity effect of fermented persimmon extracts via activation of AMP-activated protein kinase. Biol Pharm Bull. 2020;43(3):440-449.
- Direito R, Rocha J, Serra AT, et al. Anti-inflammatory effects of persimmon ( Diospyros kaki L.) in experimental rodent rheumatoid arthritis. J Diet Suppl. 2020;17(6):663-683.