Jambolan
OTHER NAME(S): Badijamun, Black Plum, Duhat, Indian Black Berry, Indian Blackberry, Jaman, Jambol Tree, Jambolan Plum, Jambolao, Jambose, Jambu, Jambul, Jamelongue, Jamelonguier, Jamum, Java Plum, Jumbul, Kavika Ni India, Mahajambu, Mesegerak, Phadena, Plum, Prune de Java, Rajajambu, Rose Apple, Syzygium cumini, Eugenia cumini, Eugenia jambolana, Syzygium jambos, Syzygium jambolanum, Syxygii cumini cortex, Jambolan seed, Plums, Syzgium cuminii, Jambosier, Jambolán
Overview
Jambolan is a tree. The seed, leaf, bark, and fruit are used to make medicine.
Jambolan is widely used in folk medicine for diabetes.
Jambolan seed and bark contains chemicals that might lower blood sugar, but extracts from jambolan leaf and fruit don't seem to affect blood sugar. Jambolan also contains chemicals that might protect against oxidation damage, as well as chemicals that reduce swelling.
It is also used by mouth for gas (flatulence), swelling (inflammation) of the stomach (gastritis), constipation, diarrhea, and other conditions.
Jambolan is sometimes used for sore throat, and applied directly to the skin for skin ulcers.
Jambolan seed and bark contains chemicals that might lower blood sugar, but extracts from jambolan leaf and fruit don't seem to affect blood sugar. Jambolan also contains chemicals that might protect against oxidation damage, as well as chemicals that reduce swelling.
Uses
We currently have no information for Jambolan overview.
Side Effects
When taken by mouth: Jambolan is POSSIBLY SAFE for most people when taken by mouth, short-term. Jambolan tea prepared from 2 grams of jambolan leaves per liter of water seems to be safe.
Precautions
When taken by mouth: Jambolan is POSSIBLY SAFE for most people when taken by mouth, short-term. Jambolan tea prepared from 2 grams of jambolan leaves per liter of water seems to be safe.
Pregnancy and breast-feeding: There isn't enough reliable information to know if jambolan is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Diabetes: Jambolan seed and bark extracts might lower blood sugar levels. Monitor blood sugar levels closely if you have diabetes and take jambolan.
Surgery: Jambolan might lower blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using jambolan at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for diabetes (Antidiabetes drugs) interacts with JambolanJambolan seed and bark extracts might decrease blood sugar levels. Diabetes medications are also used to lower blood sugar. Taking jambolan seed or bark along with diabetes medications might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
- Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with JambolanSome medications are changed and broken down by the liver. Jambolan might decrease how quickly the liver breaks down some medications. Taking jambolan along with some medications that are broken down by the liver might increase the effects and side effects of some medications. Before taking jambolan, talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.
Minor Interaction
Be watchful with this combination
- Sitagliptin (Januvia) interacts with JambolanJambolan seed extract might lower blood levels of the medication sitagliptin. Sitagliptin helps the body lower blood sugar to normal levels in patients with diabetes. Taking jambolan seed along with sitagliptin might cause changes in your blood sugar. Monitor your blood sugar closely. The dose of sitagliptin might need to be changed.
Dosing
The appropriate dose of jambolan depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for jambolan. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Teixeira CC, Weinert LS, Barbosa DC, et al. Syzygium cumini (L.) Skeels in the treatment of type 2 diabetes. Diabetes Care 2004;27:3019-20.
- Oliveira AC, Endringer DC, Amorim LA, et al. Effect of the extracts and fractions of Baccharis trimera and Syzygium cumini on glycaemia of diabetic and non-diabetic mice. J Ethnopharmacol 2005;102:465-9.
- Ravi K, Rajasekaran S, Subramanian S. Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats. Food Chem Toxicol 2005;43:1433-9.
- Teixeira CC, Rava CA, Mallman da Silva P, et al. Absence of antihyperglycemic effect of jambolan in experimental and clinical models. J Ethnopharmacol 2000;71:343-7.
- Teixeira CC, Pinto LP, Kessler FH, et al. The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus. J Ethnopharmacol 1997;56:209-13.
- Pepato MT, Mori DM, Baviera AM, et al. Fruit of the jambolan tree (Eugenia jambolana Lam.) and experimental diabetes. J Ethnopharmacol 2005;96:43-8.
- Sharma SB, Nasir A, Prabhu KM, et al. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003;85:201-6.
- Sridhar SB, Sheetal UD, Pai MR, Shastri MS. Preclinical evaluation of the antidiabetic effect of Eugenia jambolana seed powder in streptozotocin-diabetic rats. Braz J Med Biol Res 2005;38:463-8.
- Villasenor IM, Lamadrid MR. Comparative anti-hyperglycemic potentials of medicinal plants. J Ethnopharmacol 2006;104:129-31.
- Muruganandan S, Srinivasan K, Chandra S, et al. Anti-inflammatory activity of Syzygium cumini bark. Fitoterapia 2001;72:369-75.
- Ravi K, Ramachandran B, Subramanian S. Effect of Eugenia Jambolana seed kernel on antioxidant defense system in streptozotocin-induced diabetes in rats. Life Sci 2004;75:2717-31.
- Bajpai M, Pande A, Tewari SK, Prakash D. Phenolic contents and antioxidant activity of some food and medicinal plants. Int J Food Sci Nutr 2005;56:287-91.
- Ramirez RO, Roa CC Jr. The gastroprotective effect of tannins extracted from duhat (Syzygium cumini Skeels) bark on HCl/ethanol induced gastric mucosal injury in Sprague-Dawley rats. Clin Hemorheol Microcirc 2003;29:253-61.
- Stanely Mainzen Prince P, Kamalakkannan N, Menon VP. Syzigium cumini seed extracts reduce tissue damage in diabetic rat brain. J Ethnopharmacol 2003;84:205-9.
- Jagetia GC, Baliga MS, Venkatesh P. Influence of seed extract of Syzygium Cumini (Jamun) on mice exposed to different doses of gamma-radiation. J Radiat Res (Tokyo) 2005;46:59-65.
- Chandrasekaran M, Venkatesalu V. Antibacterial and antifungal activity of Syzygium jambolanum seeds. J Ethnopharmacol 2004;91:105-8.
- Shafi PM, Rosamma MK, Jamil K, Reddy PS. Antibacterial activity of Syzygium cumini and Syzygium travancoricum leaf essential oils. Fitoterapia 2002;73:414-6.
- Ulla A, Alam MA, Sikder B, et al. Supplementation of Syzygium cumini seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats. BMC Complement Altern Med 2017;17(1):289. doi: 10.1186/s12906-017-1799-8.
- Sood R, Swarup D, Bhatia S, et al. Antiviral activity of crude extracts of Eugenia jambolana Lam. against highly pathogenic avian influenza (H5N1) virus. Indian J Exp Biol 2012;50(3):179-86.
- Aqil F, Gupta A, Munagala R, et al. Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). Nutr Cancer 2012;64(3):428-38. doi: 10.1080/01635581.2012.657766.
- Xu J, Liu T, Li Y, et al. Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice. Food Funct 2018;9(6):3330-7. doi: 10.1039/c8fo00095f.
- Chinni S, Dubala A, Kosaraju J, et al. Effect of crude extract of Eugenia jambolana Lam. on human cytochrome P450 enzymes. Phytother Res 2014;28(11):1731-4. doi: 10.1002/ptr.5137.
- Vora A, Varghese A, Kachwala Y, et al. Eugenia jambolana extract reduces the systemic exposure of Sitagliptin and improves conditions associated with diabetes: A pharmacokinetic and a pharmacodynamic herb-drug interaction study. J Tradit Complement Med. 2018;9(4):364-371.
- Majeed M, Majeed A, Nagabhusahnam K, Mundkur L, Paulose S. A randomized, double-blind clinical trial of a herbal formulation (GlycaCare-II) for the management of type 2 diabetes in comparison with metformin. Diabetol Metab Syndr 2021;13(1):132.
- Araújo GR, Teles BSBS, Xoteslem GC, Gratieri T, Fortes RC, Novaes MR. Randomized, double-blind clinical trial comparing the healing of stasis ulcers in lower limbs with standard hydrocolloid gel dressings and with dressings with Syzygium cumini extract. Phlebology 2022;37(6):460-468.
