Isopropylnorsynephrine
OTHER NAME(S): Betaphrine, Deterenol, Deterenolum, Isopropyl-norsynephrine, Isopropyloctopamine, N-isopropylnorsynephrine, N-isopropyloctopamine, Paraproterenol, 1-(4-hydroxyphenyl)-2-isopropylaminoethanolangustifolia, 4-hydroxyphenyl, Isopropylnorsynephrine, Isopropilnorsinefrina, Isopropylnorsynéphrine
Overview
Isopropylnorsynephrine is a type of stimulant that may be found in some supplement products.
Stimulants can increase blood pressure and heart rate and cause heart problems.
Isopropylnorsynephrine is used for weight loss, to increase energy, improve athletic performance, and for other uses, but there is no good scientific evidence to support its use. It might also be unsafe.
Uses
We currently have no information for Isopropylnorsynephrine overview.
Side Effects
When taken by mouth: Isopropylnorsynephrine is possibly unsafe for most people when taken by mouth. Side effects can include difficulty breathing, heart attack, stroke, and others.
Precautions
When taken by mouth: Isopropylnorsynephrine is possibly unsafe for most people when taken by mouth. Side effects can include difficulty breathing, heart attack, stroke, and others.
Pregnancy and breast-feeding: Isopropylnorsynephrine is possibly unsafe to use when pregnant or breast-feeding. Avoid using.
High blood pressure: Isopropylnorsynephrine might increase blood pressure. Avoid using isopropylnorsynephrine if you have high blood pressure.
Surgery: Isopropylnorsynephrine acts like a stimulant, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking isopropylnorsynephrine at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for high blood pressure (Antihypertensive drugs) interacts with IsopropylnorsynephrineAntihypertensive drugs help lower blood pressure. Isopropylnorsynephrine might increase blood pressure. Taking isopropylnorsynephrine along with antihypertensive drugs might interfere with how well these drugs lower blood pressure.
- Stimulant drugs interacts with IsopropylnorsynephrineStimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Isopropylnorsynephrine might also speed up the nervous system. In theory, taking isopropylnorsynephrine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
Dosing
There isn't enough reliable information to know what an appropriate dose of isopropylnorsynephrine might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6.
- Mercader J, Wanecq E, Chen J, Carpéné C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. J Physiol Biochem. 2011;67(3):443-52.
- Pawar RS, Sagi S, Leontyev D. Analysis of bitter orange dietary supplements for natural and synthetic phenethylamines by LC-MS/MS. Drug Test Anal 2020;12(9):1241-51.
- Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clin Toxicol (Phila). 2021;1-7.
- Anderson WG. The sympathomimetic activity of N-isopropyloctopamine in vitro. J Pharmacol Exp Ther 1983;225(3):553-8.
- Bovee TF, Mol HG, Bienenmann-Ploum ME, et al. Dietary supplement for energy and reduced appetite containing the ß-agonist isopropyloctopamine leads to heart problems and hospitalisations. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2016;33(5):749-59.