Indian Long Pepper
OTHER NAME(S): Bi Ba, Bi Bo, Jaborandi Pepper, Kana, Langer Pfeffer, Lindipipper, Long Pepper, Magadhi, Magdhi, Pibo, Pimienta Larga, Pimenta-Longa, Pippali, Pippli, Poivrier Long, Poivrier Long d'Inde, Poivre Long Indien, Ushana, Piper longum, Indian Longpepper, Pimienta larga india, Poivre Long
Overview
Indian long pepper (Piper longum) is a plant found in Southern Asia. Its fruit and root are used in Ayurvedic medicine and as a spice in foods.
Indian long pepper fruit and root contain chemicals that might help kill certain parasites and reduce swelling. One of these chemicals is called piperine. When taken by mouth, piperine seems to allow some drugs and other substances to be better absorbed by the body.
People use Indian long pepper for asthma, lung problems, arthritis, heart disease, common cold, cough, indigestion, stress, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse Indian long pepper with other types of peppers, including black pepper, capsicum, and white pepper. These are not the same.
Uses
We currently have no information for Indian Long Pepper overview.
Side Effects
When taken by mouth: Indian long pepper fruit is commonly consumed in foods. But there isn't enough reliable information to know if Indian long pepper is safe or what the side effects might be when used in larger amounts as medicine.
Precautions
When taken by mouth: Indian long pepper fruit is commonly consumed in foods. But there isn't enough reliable information to know if Indian long pepper is safe or what the side effects might be when used in larger amounts as medicine.
Pregnancy and breast-feeding: Indian long pepper fruit is commonly consumed in foods. But there isn't enough reliable information to know if Indian long pepper is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.
Bleeding conditions: Indian long pepper might slow blood clotting. Taking Indian long pepper in amounts greater than those found in foods might increase the risk of bleeding in people with bleeding disorders.
Surgery: Indian long pepper might slow blood clotting and affect blood sugar levels. Taking Indian long pepper in amounts greater than those found in foods might cause bleeding complications or affect blood sugar levels during surgery. Stop taking Indian long pepper at least 2 weeks before surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Phenytoin (Dilantin) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. The piperine in Indian long pepper might increase how much phenytoin the body absorbs. This might increase the effects and side effects of phenytoin.
- Propranolol (Inderal) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. The piperine in Indian long pepper might increase how much propranolol the body absorbs. This might increase the effects and side effects of propranolol.
- Theophylline interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. The piperine in Indian long pepper might increase how much theophylline the body absorbs. This might increase the effects and side effects of theophylline.
- Medications moved by pumps in cells (P-glycoprotein substrates) interacts with Indian Long PepperSome medications are moved in and out of cells by pumps. Indian long pepper might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Indian Long PepperIndian long pepper might slow blood clotting. Taking Indian long pepper along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
- Pentobarbital (Nembutal) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. The piperine in Indian long pepper might increase the sleepiness caused by pentobarbital.
- Rifampin (Rifadin) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. The piperine in Indian long pepper might increase how much rifampin the body absorbs. This might increase the effects and side effects of rifampin.
- Cyclosporine (Neoral, Sandimmune) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. Piperine might increase levels of cyclosporine in the body. This might increase the effects and side effects of cyclosporine. But it's not clear if this is a big concern.
- Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with Indian Long PepperSome medications are changed and broken down by the liver. Indian long pepper might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 2B1 (CYP2B1) substrates) interacts with Indian Long PepperSome medications are changed and broken down by the liver. Indian long pepper might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Indian Long PepperSome medications are changed and broken down by the liver. Indian long pepper might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications for diabetes (Antidiabetes drugs) interacts with Indian Long PepperIndian long pepper might lower blood sugar levels. Taking Indian long pepper along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Minor Interaction
Be watchful with this combination
- Nevirapine (Viramune) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. Piperine might increase levels of nevirapine in the body. Taking Indian long pepper with nevirapine might increase the effects and side effects of nevirapine. But it's not clear if this is a big concern.
- Amoxicillin (Amoxil, Trimox) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. Piperine might increase the amount of amoxicillin absorbed by the body. This might increase the effects and side effects of amoxicillin. But it's not clear if this is a big concern.
- Carbamazepine (Tegretol) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. Piperine might increase the amount of carbamazepine absorbed by the body. This might increase the chance of side effects. But it's not clear if this is a big concern.
- Cefotaxime (Claforan) interacts with Indian Long PepperIndian long pepper contains a chemical called piperine. Piperine might increase levels of cefotaxime in the blood. This might increase the effects and side effects of cefotaxime. But it's not clear if this is a big concern.
Dosing
There isn't enough reliable information to know what an appropriate dose of Indian long pepper might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9.
- Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7.
- Agarwal AK, Singh M, Gupta N, et al. Management of giardiasis by an immuno-modulatory herbal drug Pippali rasayana. J Ethnopharmacol 1994;44:143-6.
- Agarwal AK, Tripathi DM, Sahai R, et al. Management of giardiasis by a herbal drug Pippali Rasayana: a clinical study. J Ethnopharmacol 1997;56:233-6.
- Shah AH, Al-Shareef AH, Ageel AM, Qureshi S. Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits. Plant Foods Hum Nutr 1998;52:231-9.
- Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption-an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol 1998;36:46-50.
- Ghoshal S, Prasad BN, Lakshmi V. Antiamoebic activity of Piper longum fruits against Entamoeba histolytica in vitro and in vivo. J Ethnopharmacol 1996;50:167-70.
- Bhardwaj RK, Glaeser H, Becquemont L, et al. Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 2002;302:645-50.
- Pattanaik S, Hota D, Prabhakar S, et al. Pharmacokinetic interaction of a single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res 2009;23:1281-6.
- Kasibhatta, R. and Naidu, M. U. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs R.D. 2007;8(6):383-391.
- Reen, R. K., Roesch, S. F., Kiefer, F., Wiebel, F. J., and Singh, J. Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line. Biochem.Biophys.Res.Commun. 1-17-1996;218(2):562-569.
- Mujumdar, A. M., Dhuley, J. N., Deshmukh, V. K., Raman, P. H., Thorat, S. L., and Naik, S. R. Effect of piperine on pentobarbitone induced hypnosis in rats. Indian J Exp.Biol. 1990;28(5):486-487.
- Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. Horm.Metab Res. 2003;35(9):523-526.
- Hiwale, A. R., Dhuley, J. N., and Naik, S. R. Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats. Indian J Exp.Biol. 2002;40(3):277-281.
- Han, Y., Chin Tan, T. M., and Lim, L. Y. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. Toxicol.Appl.Pharmacol. 8-1-2008;230(3):283-289.
- Sharma, P., Varma, M. V., Chawla, H. P., and Panchagnula, R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 2005;60(11-12):874-883.
- Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc.Physicians India 1985;33(3):223-224.
- Reen, R. K., Wiebel, F. J., and Singh, J. Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1. J Ethnopharmacol. 1997;58(3):165-173.
- Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91.
- Lu C, Zhang B, Xu T, et al. Piperlongumine reduces ovalbumin induced asthma and airway inflammation by regulating nuclear factor ?B activation. Int J Mol Med. 2019;44(5):1855-1865.
- Go J, Park TS, Han GH, et al. Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice. Int J Mol Med. 2018;42(4):1875-1884.
- Yadav V, Krishnan A, Vohora D. A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacol. 2020;247:112255.
- Guo Z, Xu J, Xia J, Wu Z, Lei J, Yu J. Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L. J Pharm Pharmacol. 2019;71(7):1162-1171.
- Shah SB, Guttal GK, Chikkanna U, Sajjanar NJ. Efficacy of Pippali in vardhamana and fixed dosage pattern in primary hypothyroidism - A randomized clinical trial. J Ayurveda Integr Med 2022;13(2):100555.