Guava
OTHER NAME(S): Amrood, Amrut Phala, Araçá-Goiaba, Araçá-Guaçú, Banjiro, Brazilian Guava, Brazilian Red Guava, Common Guava, Fan Shi Liu, Feuille de Goyavier, Goiaba, Goiabeiro, Goyabe, Goyave Jaune, Goyave Rouge, Goyavier, Goyavier du Brésil, Guaiaba, Guaiava, Guajava, Guava Leaf, Guava Leaves, Guava Peel, Guava Pulp, Guava Seed, Guava Seed Protein, Guavas, Guave, Guavenbaum, Guayabo, Guayave, Gwaaba, Jambu Batu, Koejawel, Lemon Guava, Mansala, Pépin de Goyave, Psidium, Pulpe de Goyave, Red Guava, Yellow Guava, Psidium guajava, Guayaba, Goyave
Overview
Guava is a tree that grows in Central and South America. The fruit is commonly eaten fresh or made into beverages, jams, and other foods. Various parts of the plant, including the leaf and the fruit, are used as medicine.
People use guava leaf for stomach and intestinal conditions, pain, diabetes, and wound healing. The fruit is used for high blood pressure. But there is no good scientific evidence to support any uses of guava.
The guava FRUIT is a source of vitamin C, fiber, and other substances that act like antioxidants. Antioxidants slow down or stop the harmful effects of oxidation. Oxidation is a chemical reaction in which oxygen is added to a chemical element or compound. Guava LEAVES also contain chemicals with antioxidant and other effects. It is not known how guava works for medical conditions.
The guava FRUIT is a source of vitamin C, fiber, and other substances that act like antioxidants. Antioxidants slow down or stop the harmful effects of oxidation. Oxidation is a chemical reaction in which oxygen is added to a chemical element or compound. Guava LEAVES also contain chemicals with antioxidant and other effects. It is not known how guava works for medical conditions.
Uses
Insufficient Evidence for
- Diarrhea. Taking guava leaf extract with oral rehydration therapy (ORT) doesn't seem to shorten the duration of diarrhea or reduce pain. But it might help to reduce how often stomach pain occurs.
- Menstrual cramps (dysmenorrhea). Early research shows that taking guava leaf extract might reduce menstrual cramps by a small amount.
- A mild form of gum disease (gingivitis). Rinsing the mouth with guava leaf extract might reduce gum disease in people with gingivitis. But it doesn't seem to reduce plaque.
- High blood pressure. Early research shows that eating large amounts of guava daily in place of high-fat foods for 12 weeks lowers blood pressure in people with high blood pressure.
- Knee pain. Early research shows that taking guava leaf extract may reduce pain and stiffness by a small amount in people with knee pain.
- Colic.
- Ulcerative colitis.
- Vomiting.
- Gas (flatulence).
- Diabetes.
- Cough.
- Cataracts.
- High cholesterol.
- Heart disease.
- Cancer.
- Obesity.
- Pain.
- Hair growth.
- Skin and nail health.
- Sleep.
- Skin infections , when applied to the skin.
- Fever, when applied to the skin.
- Vaginal infections and irritation, when applied to the skin.
- Skin wounds, when applied to the skin.
- Other conditions.
More evidence is needed to rate the effectiveness of guava for these uses.
Side Effects
When taken by mouth: Guava fruit is LIKELY SAFE when eaten as a food. Guava fruit and guava leaf extract are POSSIBLY SAFE when used as a medicine, short-term. Guava leaf extract might cause temporary nausea or stomach pain in some people.
When applied to the skin: Guava leaf extract is POSSIBLY SAFE when applied to the skin or inside the mouth as a rinse. It might cause skin irritation in some people.
Precautions
When taken by mouth: Guava fruit is LIKELY SAFE when eaten as a food. Guava fruit and guava leaf extract are POSSIBLY SAFE when used as a medicine, short-term. Guava leaf extract might cause temporary nausea or stomach pain in some people.
When applied to the skin: Guava leaf extract is POSSIBLY SAFE when applied to the skin or inside the mouth as a rinse. It might cause skin irritation in some people.
Pregnancy and breast-feeding: Guava is LIKELY SAFE when eaten as food. There isn't enough reliable information to know if guava is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and stick with food amounts until more is known.
Eczema: Guava leaf extract might make eczema worse. Guava leaf extract contains chemicals that can cause skin irritation, especially in people with skin conditions like eczema. If you have eczema, use guava leaf extract with caution.
Diabetes: Guava might lower blood sugar. If you have diabetes and use guava, check your blood sugar carefully.
Surgery: Guava might lower blood sugar. In theory, guava might increase the risk for bleeding or interfere with blood sugar control during and after surgical procedures. Stop using guava as a medicine at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for diabetes (Antidiabetes drugs) interacts with GuavaGuava might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking guava along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Dosing
The appropriate dose of guava depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for guava. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Conde Garcia EA, Nascimento VT, Santiago Santos AB. Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium. Braz J Med Biol Res 2003;36:661-8.
- Qian H, Nihorimbere V. Antioxidant power of phytochemicals from Psidium guajava leaf. J Zhejiang Univ Sci 2004;5:676-83.
- Belemtougri RG, Constantin B, Cognard C, et al. Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture. Zhejiang Univ Sci B 2006;7:56-63.
- Mercadante AZ, Steck A, Pfander H. Carotenoids from guava (Psidium guajava l.): isolation and structure elucidation. J Agric Food Chem 1999;47:145-51.
- Jimenez-Escrig A, Rincon M, Pulido R, Saura-Calixto F. Guava fruit (Psidium guajava L.) as a new source of antioxidant dietary fiber. J Agric Food Chem 2001;49:5489-93.
- Hassimotto NM, Genovese MI, Lajolo FM. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. J Agric Food Chem 2005;53:2928-35.
- Rahmat A, Abu Bakar MF, Faezah N, Hambali Z. The effects of consumption of guava (psidium guajava) or papaya (carica papaya) on total antioxidant and lipid profile in normal male youth. Asia Pac J Clin Nutr 2004;13(Suppl):S106..
- Yusof RM, Said M. Effect of high fibre fruit (Guava - psidium guajava L.) on the serum glucose level in induced diabetic mice. Asia Pac J Clin Nutr 2004;13(Suppl):S135.
- Lozoya, X., Reyes-Morales, H., Chavez-Soto, M. A., Martinez-Garcia, Mdel C., Soto-Gonzalez, Y., and Doubova, S. V. Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease. J Ethnopharmacol 2002;83(1-2):19-24.
- Correa MG, Couto JS, Teodoro AJ. Anticancer Properties of Psidium guajava - a Mini-Review. Asian Pac J Cancer Prev. 2016;17(9):4199-4204.
- Kumari S, Rakavi R, Mangaraj M. Effect of Guava in Blood Glucose and Lipid Profile in Healthy Human Subjects: A Randomized Controlled Study. J Clin Diagn Res. 2016;10(9):BC04-BC07.
- Obi M, Miyazaki Y, Yokozeki H, Nishioka K. Allergic contact dermatitis due to guava tea. Contact Dermatitis. 2001;44(2):116-7.
- Singh RB, Rastogi SS, Singh R, Ghosh S, Niaz MA. Effects of guava intake on serum total and high-density lipoprotein cholesterol levels and on systemic blood pressure. Am J Cardiol. 1992;70(15):1287-91.
- Thaptimthong T, Kasemsuk T, Sibmooh N, Unchern S. Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers. BMC Complement Altern Med. 2016;16:269.
- Nayak N, Varghese J, Shetty S, et al. Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebo-controlled clinical trial. BMC Complement Altern Med. 2019;19(1):327.
- Tella T, Masola B, Mukaratirwa S. The effect of Psidium guajava aqueous leaf extract on liver glycogen enzymes, hormone sensitive lipase and serum lipid profile in diabetic rats. Biomed Pharmacother. 2019;109:2441-2446.
- Pongsakornpaisan P, Lourith N, Kanlayavattanakul M. Anti-sebum efficacy of guava toner: A split-face, randomized, single-blind placebo-controlled study. J Cosmet Dermatol. 2019;18(6):1737-1741.
- Kakuo S, Fushimi T, Kawasaki K, Nakamura J, Ota N. Effects of Psidium guajava Linn. Leaf extract in Japanese subjects with knee pain: a randomized, double-blind, placebo-controlled, parallel pilot study. Aging Clin Exp Res. 2018;30(11):1391-1398.
- Gutiérrez RM, Mitchell S, Solis RV. Psidium guajava: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2008;117(1):1-27.
- Doubova SV, Morales HR, Hernández SF, et al. Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: a randomized clinical trial. J Ethnopharmacol. 2007;110(2):305-10.
