Glucuronolactone
OTHER NAME(S): D-Glucurono-1,4-lactone, D-Glucurono-3,6-lactone, D-Glucurono-gamma-lactone, D-Glucuronolactone, Glucuronolactone, Glucuronolactona
Overview
Glucuronolactone is a chemical. It can be made by the body. It is also found in foods and made in laboratories.
Glucuronolactone is commonly used as an ingredient in "energy" drinks to increase attention and improve athletic performance, but there is no good scientific evidence to support its use.
There isn't enough information to know how glucuronolactone might work as a medicine.
There isn't enough information to know how glucuronolactone might work as a medicine.
Uses
Insufficient Evidence for
- Liver damage caused by tuberculosis drugs.
- Preventing liver damage.
- Increasing attention.
- Athletic performance.
- Other conditions.
More evidence is needed to rate the effectiveness of glucuronolactone for these uses.
Side Effects
When taken by mouth: Glucuronolactone is LIKELY SAFE when used in food amounts. There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth in higher amounts.
Precautions
When taken by mouth: Glucuronolactone is LIKELY SAFE when used in food amounts. There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth in higher amounts.
Pregnancy and breast-feeding: There isn't enough reliable information to know if glucuronolactone is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
Children:There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth. Stay on the safe side and stick to food amounts.
Interactions
We currently have no information for Glucuronolactone overview.
Dosing
The appropriate dose of glucuronolactone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glucuronolactone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Marsh CA. Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action. Biochem J. 1966;99(1):22-7.
- Marsh CA. Metabolism of d-glucuronolactone in mammalian systems. Identification of d-glucaric acid as a normal constituent of urine. Biochem J. 1963;86(1):77-86.
- Marsh CA. Metabolism of d-glucuronolactone in mammalian systems. 2. Conversion of d-glucuronolactone into d-glucaric acid by tissue preparations. Biochem J. 1963;87(1):82-90.
- Tamura S, Tsutsumi S, Ito H, Nakai K, Masuda M. Effects of glucuronolactone and the other carbohydrates on the biochemical changes produced in the living body of rats by hard exercise. Jpn J Pharmacol. 1968;18(1):30-8.
- Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clin Proc. 2010;85(11):1033-41.
- Basrai M, Schweinlin A, Menzel J, et al. Energy drinks induce acute cardiovascular and metabolic changes pointing to potential risks for young adults: A randomized controlled trial. J Nutr. 2019;149(3):441-450.
- Opinion of the panel on food additives, flavourings, processing aids, materials in contact with food and cosmetics of the Norwegian Scientific Committee for Food Safety: Risk assessment of "other substances" -D-glucurono-?-lactone. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&cad=rja&uact=8&ved=2ahUKEwiDpsKY2JXoAhWCqp4KHfEiDjkQFjAEegQIBBAB&url=https%3A%2F%2Fvkm.no%2Fdownload%2F18.645b840415d03a2fe8f260ad%2F1502803227005%2FRisk%2520assessment%2520of%2520%2522other%2520substances%2522%2520%25E2%2580%2593%2520D-Glucurono-%25CE%25B3-lactone.pdf&usg=AOvVaw0KHxHAYpQMwH-qbTiiuzV8. Accessed June 24, 2020.
- The use of taurine and D-glucurono-?-lactone as constituents of the so-called "energy" drinks. European Food Safety Authority. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2009.935. Accessed June 24, 2020.