Genistein Combined Polysaccharide
OTHER NAME(S): Basidiomycetes Polysaccharide, Fermented Genistein, Fermented Isoflavone, GCP, Genistein Polysaccharide, Génistéine du Polysaccharide Combiné, Génistéine Fermentée, Isoflavone Combined Polysaccharide, Isoflavone Fermentée, Polisacáridos Combinados de Genisteína, Polysaccharide de Génistéine, Polysaccharide des Basidiomycètes, Polysaccharide d'Isoflavone de Soja, Soy Isoflavone Polysaccharide, Genistein Combined Polysaccharide, Polisacárido Combinado de Genisteína, Polysaccharide combiné à la génistéine
Overview
Genistein combined polysaccharide is a chemical that is made by fermenting soy with a certain type of mushroom called basidiomycetes.
Genistein combined polysaccharide is made up of genistein, a chemical found in soy, and a certain type of polysaccharide found in mushrooms. It might alter levels of some hormones in the body.
Genistein combined polysaccharide is used for prostate cancer, bladder cancer, and breast cancer, but there is no good scientific evidence to support any use.
Uses
We currently have no information for Genistein Combined Polysaccharide overview.
Side Effects
When taken by mouth: There isn't enough reliable information to know if genistein combined polysaccharide is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if genistein combined polysaccharide is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn’t enough reliable information to know if genistein combined polysaccharide is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Genistein combined polysaccharide might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use genistein combined polysaccharide.
Interactions
Moderate Interaction
Be cautious with this combination
- Caffeine interacts with Genistein Combined PolysaccharideGenistein combined polysaccharide contains a chemical called genistein. Genistein might slow down how quickly the body gets rid of caffeine. This might increase the effects of caffeine.
Dosing
There isn’t enough reliable information to know what an appropriate dose of genistein combined polysaccharide might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Barnes S, Kim H, Darley-Usmar V, et al. Beyond ERalpha and ERbeta: Estrogen receptor binding is only part of the isoflavone story. J Nutr 2000;130:656S-7S.
- Ghafar MA, Golliday E, Bingham J, et al. Regression of prostate cancer following administration of genistein combined polysaccharide (GCP), a nutritional supplement: A case report. J Altern Complement Med 2002;8:493-7.
- Yuan L, Wagatsuma C, Yoshida M, et al. Inhibition of human breast cancer growth by GCPTM (genistein combined polysaccharide) in xenogeneic athymic mice: involvement of genistein biotransformation by beta-glucuronidase from tumor tissues. Mutation Res 2003;523-524:55-62.
- Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353.
- Capodice JL, Cammack AS, McKiernan JM, Katz AE. Two case reports on the use of genistein combined polysaccharide (GCP) against bladder cancer recurrence. J Complement Integr Med 2011;8.