Gamma-oryzanol
OTHER NAME(S): Gama Orizanol, Gamma Oryzanol, Gamma-OZ, Oryzanol, Gamma-oryzanol, Gamma-orizanol
Overview
Gamma-oryzanol is group of chemicals found in rice bran oil. It is also found in wheat bran and some fruits and vegetables.
Gamma-oryzanol isn't absorbed well in the gut. Because of this, it might reduce cholesterol levels by reducing how much cholesterol is absorbed from foods.
People use gamma-oryzanol for high cholesterol, symptoms of menopause, athletic performance, eczema, high blood pressure, and many other conditions, but there is no good scientific evidence to support most of these uses.
Uses
Possibly Effective for
- Abnormal levels of cholesterol or blood fats (dyslipidemia). Taking gamma-oryzanol by mouth might decrease total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and blood fats called triglycerides in people with high cholesterol.
There is interest in using gamma-oryzanol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When taken by mouth: Gamma-oryzanol is possibly safe when used in doses up to 300 mg daily. It seems to be well-tolerated.
When applied to the skin: Gamma-oryzanol is possibly safe when used appropriately.
Precautions
When taken by mouth: Gamma-oryzanol is possibly safe when used in doses up to 300 mg daily. It seems to be well-tolerated.
When applied to the skin: Gamma-oryzanol is possibly safe when used appropriately.
Pregnancy and breast-feeding: There isn't enough reliable information to know if gamma-oryzanol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Thyroid conditions: Gamma-oryzanol might change thyroid function. Speak with a healthcare provider before using gamma-oryzanol if you have a thyroid condition.
Interactions
We currently have no information for Gamma-oryzanol overview.
Dosing
Gamma-oryzanol has most often been used by adults in doses of 100-300 mg by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.
References
- Fry AC, et al. The effects of gamma-oryzanol supplementation during resistance exercise training. Int J Sport Nutr 1997;7:318-29.
- Sasaki J, Takada Y, Handa K, et al. Effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers. Clin Ther 1990;12:263-8.
- Shimomura Y, Kobayashi I, Maruto S, et al. Effect of gamma-oryzanol on serum TSH concentrations in primary hypothyroidism. Endocrinol Jpn 1980;27:83-6.
- Sugano M, Tsuji E. Rice bran oil and human health. Biomed Environ Sci 1996;9:242-6.
- Wheeler KB, Garleb KA. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects. Int J Sport Nutr 1991;1:170-7.
- Seetharamaiah GS, Chandrasekhara N. Effect of oryzanol on cholesterol absorption and biliary and fecal bile acids in rats. Indian J Med Res 1990;92:471-5.
- Ishihara M, Ito Y, Nakakita T, et al. [Clinical effect of gamma-oryzanol on climacteric disturbance- on serum lipid peroxides]. Nippon Sanka Fujinka Gakkai Zasshi 1982;34:243-51.
- Grunewald KK, Bailey RS. Commercially marketed supplements for bodybuilding athletes. Sports Med 1993;15:90-103.
- Sugano M, Koba K, Tsuji E. Health benefits of rice bran oil. Anticancer Res 1999;19:3651-7.
- Ng, S. S. and Figg, W. D. Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice. Anticancer Res 2003;23(5A):3585-3590.
- Xu, Z. and Godber, J. S. Purification and identification of components of gamma-oryzanol in rice bran Oil. J Agric.Food Chem 1999;47(7):2724-2728.
- Itaya, K., Kitonaga, J., and Ishikawa, M. [Studies of gamma-oryzanol. (2) The antiulcerogenic action]. Nippon Yakurigaku Zasshi 1976;72(8):1001-1011.
- Xu, Z., Hua, N., and Godber, J. S. Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. J Agric.Food Chem 2001;49(4):2077-2081.
- Cicero, A. F. and Gaddi, A. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother Res 2001;15(4):277-289.
- Rosenbloom, C., Millard-Stafford, M., and Lathrop, J. Contemporary ergogenic aids used by strength/power athletes. J Am Diet Assoc 1992;92(10):1264-1266.
- Parrado, J., Miramontes, E., Jover, M., Marquez, J. C., Angeles, Mejias M., Collantes, De Teran, Absi, E., and Bautista, J. Prevention of brain protein and lipid oxidation elicited by a water-soluble oryzanol enzymatic extract derived from rice bran. Eur J Nutr 2003;42(6):307-314.
- Berger, A., Rein, D., Schafer, A., Monnard, I., Gremaud, G., Lambelet, P., and Bertoli, C. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men*. Eur J Nutr 2005;44(3):163-173.
- Most, M. M., Tulley, R., Morales, S., and Lefevre, M. Rice bran oil, not fiber, lowers cholesterol in humans. Am J Clin Nutr 2005;81(1):64-68.
- Juliano, C., Cossu, M., Alamanni, M. C., and Piu, L. Antioxidant activity of gamma-oryzanol: mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int J Pharm 8-11-2005;299(1-2):146-154.
- Suh, M. H., Yoo, S. H., Chang, P. S., and Lee, H. G. Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats. J Agric.Food Chem 12-14-2005;53(25):9747-9750.
- Accinni, R., Rosina, M., Bamonti, F., Della, Noce C., Tonini, A., Bernacchi, F., Campolo, J., Caruso, R., Novembrino, C., Ghersi, L., Lonati, S., Grossi, S., Ippolito, S., Lorenzano, E., Ciani, A., and Gorini, M. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects. Nutr Metab Cardiovasc.Dis. 2006;16(2):121-127.
- Chen, C. W. and Cheng, H. H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J Nutr 2006;136(6):1472-1476.
- Rukmini, C. and Raghuram, T. C. Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. J Am Coll Nutr 1991;10(6):593-601.
- Ichimaru, Y., Moriyama, M., Ichimaru, M., and Gomita, Y. [Effects of gamma-oryzanol on gastric lesions and small intestinal propulsive activity in mice]. Nippon Yakurigaku Zasshi 1984;84(6):537-542.
- Arai, T. [Effect of gamma-oryzanol on indefinite complaints in the gastrointestinal symptoms in patients with chronic gastritis--studies on the endocrinological environment (author's transl)]. Horumon To Rinsho 1982;30(3):271-279.
- Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., and Ito, N. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene. Cancer Lett. 8-15-1994;83(1-2):149-156.
- Lichtenstein, A. H., Ausman, L. M., Carrasco, W., Gualtieri, L. J., Jenner, J. L., Ordovas, J. M., Nicolosi, R. J., Goldin, B. R., and Schaefer, E. J. Rice bran oil consumption and plasma lipid levels in moderately hypercholesterolemic humans. Arterioscler.Thromb. 1994;14(4):549-556.
- Kitazume, H., Ageishi, Y., Iwama, T., Kubo, I., and Suzuki, A. [Ticlopidine may prevent subtotal or total occlusion of dilated lesions after percutaneous coronary angioplasty]. J Cardiol 1993;23(2):149-155.
- Sugano, M. and Tsuji, E. Rice bran oil and cholesterol metabolism. J Nutr 1997;127(3):521S-524S.
- Yoshino, G., Kazumi, T., Amano., M., Tateiwa., M., Yamasaki, T., Takashima, S., Iwai, M., Hatanaka, H., and Baba, S. Effects of gamma-oryzanol on hyperlipidemic subjects. Current Therapeutic Research, Clinical & Experimental 1989;45(4):543-552.
- Yoshino, G., Kazumi, T., Amano., M., Tateiwa., M., Yamasaki, T., Takashima, S., Iwai, M., Hatanaka, H., and Baba, S. Effects of gamma-oryzanol and probucol on hyperlipidemia. Current Therapeutic Research, Clinical & Experimental 1989;45(6):975-982.
- Suwa, M., Inoue, H., Adachi, Y., Nagamine, Y., and Yamamoto, T. Treatment of hyperlipidemia with probucol, gamma-oryzanol or their combination. Medical Journal of Kinki University 1988;13(4 Suppl.):83-85.
- Hayakawa, R., Suzuki, M., and Ogino, Y. Clinical evaluation of gamma-oryzanol on skin diseases with dry skin. Acata Dermatologica 1994;89(1):115-119.
- Fujiwaki, T. and Furusho, K. An open study of gamm-oryzanol as a bath product for children with atopic dermatitis. Acta Paediatrica Hungarica 1993;33(3-4):287-298.
- Hayakawa, R. Clinical evaluation of FC-9201 cream containing 1.0% gamma-oryzanol. Skin Research 1993;35(1):131-154.
- Tezuka, T. The clinical effects of bathquina for dry, scaly skin of atopic dermatitis patients. Skin Research 1992;34(5):624-638.
- Devarajan S, Singh R, Chatterjee B, Zhang B, Ali A. A blend of sesame oil and rice bran oil lowers blood pressure and improves the lipid profile in mild-to-moderate hypertensive patients. J Clin Lipidol. 2016;10(2):339-49.
- Bumrungpert A, Chongsuwat R, Phosat C, Butacnum A. Rice Bran Oil Containing Gamma-Oryzanol Improves Lipid Profiles and Antioxidant Status in Hyperlipidemic Subjects: A Randomized Double-Blind Controlled Trial. J Altern Complement Med. 2019;25(3):353-358.
- Eslami S, Esa NM, Marandi SM, Ghasemi G, Eslami S. Effects of gamma oryzanol supplementation on anthropometric measurements & muscular strength in healthy males following chronic resistance training. Indian J Med Res. 2014;139(6):857-63.
- Mäkynen K, Chitchumroonchokchai C, Adisakwattana S, Failla M, Ariyapitipun T. Effect of gamma-oryzanol on the bioaccessibility and synthesis of cholesterol. Eur Rev Med Pharmacol Sci. 2012;16(1):49-56.
- Minatel IO, Lee YM, Yoon H, et al. Antiadipogenic Activity of y-Oryzanol and Its Stability in Pigmented Rice. J Med Food. 2016;19(7):710-5.
- Wang L, Lin Q, Yang T, et al. Oryzanol Modifies High Fat Diet-Induced Obesity, Liver Gene Expression Profile, and Inflammation Response in Mice. J Agric Food Chem. 2017;65(38):8374-8385.
- Wang O, Liu J, Cheng Q, et al. Effects of ferulic acid and ?-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats. PLoS One. 2015;10(2):e0118135.
- Ahn J, Son HJ, Seo HD, et al. ?-Oryzanol improves exercise endurance and muscle strength by upregulating PPARd and ERR? activity in aged mice. Mol Nutr Food Res. 2021 Jul;65(14):e2000652.
- Xia X, Lin H, Luo F, et al. Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-?B/NLRP3 Cascade Response In Vivo. J Agric Food Chem 2022;70(50):15747-15762.
- De Lellis LF, Morone MV, Buccato DG, et al. Efficacy of Food Supplement Based on Monacolins, ?-Oryzanol, and ?-Aminobutyric Acid in Mild Dyslipidemia: A Randomized, Double-Blind, Parallel-Armed, Placebo-Controlled Clinical Trial. Nutrients 2024;16(17):2983.
- Kuang YY, Xiong MQ, Cai JX. Clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome. World J Clin Cases 2024;12(22):4992-4998.
- Fan Z, Zhan W, Cai J. Effects of ?-oryzanol on motor function in a spinal cord injury model. Transl Neurosci 2023;14(1):20220310.
