Fennel
OTHER NAME(S): Adas, Almindelig fennikel, Arapsaci, Badian, Badishep, Bari-Sanuf, Bisbas, Bitterfenchel, Bitter Fennel, Carosella, Common Fennel, Dunkler Fenchel, Endro, Erva-doce, Fänkål, Fenchel, Fenchle, Fenkuł, Fennel Essential Oil, Fennel Oil, Fennel Seed, Fenneru, Fennikel, Fenoll, Fenouil Amer, Fenouil Bulbeux, Fenouil Commun, Fenouil de Florence, Fenouil des Vignes, Fenouil Doux, Fenouille, Fenouil Sauvage, Fenykl, Finnochio, Fiollo, Florence Fennel, Foeniculi Antheroleum, Foeniculum Vulgare Fruit, Fonoll, Funcho, Garden Fennel, Graine de Fenouil, Hariyal, Huile Essentielle de Fenouil, Huile de Fenouil, Hui xiang, Hullebe, Inuju, Jinuchchu, Komorač, Koper, Koper włoski, Koromač, Kumurač, Large Fennel, Malatura, Mauri, Mieloi, Millua, Morac, Moroč, Morača, Pānmourī, Phak chi, Phaksi, Phytoestrogen, Razianaj, Rezene, Sanuf, Saunf, Shatapuspha, Shoap, Shomar, Shouikya, Sohoehyang, Sweet Fennel, Uikyou, Variyali, Venkel, Vinkel, Wilder Fenchel, Wild Fennel, Xiao Hui Xiang, Yira, Foeniculum vulgare, Anethum piperitum, Foeniculum piperitum, Foeniculum officinale, Foeniculum capillaceum, Anethum foeniculum, Fennel Oil, Fennel Seed, Hinojo, Fenouil
Overview
Fennel (Foeniculum vulgare) is an herb with yellow flowers. The dried seeds are used in food. The dried seeds and oil are also used as medicine.
Fennel is native to the Mediterranean, but is now found throughout the world. As medicine, it might relax the colon, and also appears to contain an ingredient that may act like estrogen in the body. As a spice, fennel has an anise-like taste.
People use fennel for menstrual cramps. It is also used for excessive crying in infants (colic), indigestion, and symptoms of menopause, but there is no good scientific evidence to support most of these uses.
Uses
Possibly Effective for
- Menstrual cramps (dysmenorrhea). Taking fennel oil or fennel extract by mouth seems to improve pain in people with menstrual cramps. Its effect on pain might be similar to drugs such as ibuprofen or mefenamic acid.
There is interest in using fennel for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When taken by mouth: Fennel is commonly consumed in foods. It is possibly safe when used as medicine at appropriate doses for a short period of time. There isn't enough reliable information to know whether fennel is safe when used long-term. Although rare, side effects might include stomach upset and seizures.
When applied to the skin: Fennel is possibly safe. Fennel can make skin extra sensitive to the sun and make it easier to get a sunburn. Wear sunblock if you are light-skinned.
Precautions
When taken by mouth: Fennel is commonly consumed in foods. It is possibly safe when used as medicine at appropriate doses for a short period of time. There isn't enough reliable information to know whether fennel is safe when used long-term. Although rare, side effects might include stomach upset and seizures.
When applied to the skin: Fennel is possibly safe. Fennel can make skin extra sensitive to the sun and make it easier to get a sunburn. Wear sunblock if you are light-skinned.
Pregnancy: Fennel is possibly unsafe to use when pregnant. Regularly using fennel has been linked to preterm birth.
Breast-feeding: Fennel is possibly unsafe. There are some reports of breast-feeding infants with damage to their nervous systems after they were exposed to herbal tea containing fennel through breastmilk.
Children: Fennel is possibly safe when used at appropriate doses for up to one week in young infants with colic.
Allergy to celery, carrot or mugwort: Fennel might cause an allergic reaction in people who are sensitive to these plants.
Bleeding disorders: Fennel might slow blood clotting. Taking fennel might increase the risk of bleeding or bruising in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Fennel might act like estrogen. If you have any condition that might be made worse by estrogen, do not use fennel.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with FennelFennel might slow blood clotting. Taking fennel along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with FennelSome medications are changed and broken down by the liver. Fennel might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Birth control pills (Contraceptive drugs) interacts with FennelSome birth control pills contain estrogen. Large amounts of fennel might affect estrogen levels in the body. Taking fennel along with birth control pills might decrease the effects of birth control pills. If you take birth control pills along with fennel, use an additional form of birth control such as a condom.
- Ciprofloxacin (Cipro) interacts with FennelCiprofloxacin is an antibiotic. Fennel might decrease how much ciprofloxacin the body absorbs. Taking fennel along with ciprofloxacin might decrease the effects of ciprofloxacin. To avoid this interaction, take fennel at least one hour after ciprofloxacin.
- Estrogens interacts with FennelLarge amounts of fennel might have some of the same effects as estrogen. Taking fennel along with estrogen might decrease the effects of estrogen.
- Tamoxifen (Nolvadex) interacts with FennelLarge amounts of fennel seem to affect estrogen levels in the body. Taking fennel along with tamoxifen might decrease the effects of tamoxifen.
Dosing
Fennel is available in many different types of products, including essential oils, seed extracts, seed powders, teas, and creams. There isn't enough reliable information to know what an appropriate dose of fennel might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Zhu M, Wong PY, Li RC. Effect of oral administration of fennel (Foeniculum vulgare) on ciprofloxacin absorption and disposition in the rat. J Pharm Pharmacol 1999;51:1391-6.
- Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
- Lund B, Storm TL, Lund B, et al. Bone mineral loss, bone histomorphometry and vitamin D metabolism in patients with rheumatoid arthritis on long-term glucocorticoid treatment. Clin Rheumatol 1985;4:143-9..
- Ostad SN, Soodi M, Shariffzadeh M, et al. The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J Ethnopharmacol 2001;76:299-304..
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70.
- Pitasawat B, Champakaew D, Choochote W, et al. Aromatic plant-derived essential oil: an alternative larvicide for mosquito control. Fitoterapia 2007;78:205-10.
- Savino F, Cresi F, Castagno E, et al. A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants. Phytother Res 2005;19:335-40.
- Rosti L, Nardini A, Bettinelli ME, Rosti D. Toxic effects of a herbal tea mixture in two newborns. Acta Paediatrica 1994;83:683.
- Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42.
- Chakurski I, Matev M, Koichev A, et al. [Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinaliss, Calendula officinalis and Foeniculum vulgare]. Vutr Boles. 1981;20:51-4.
- Weizman Z, Alkrinawi S, Goldfarb D, et al. Efficacy of herbal tea preparation in infantile colic. J Pediatr 1993;122(4):650-652.
- Lee, H. S. Acaricidal activity of constituents identified in Foeniculum vulgare fruit oil against Dermatophagoides spp. (Acari: Pyroglyphidae). J Agric.Food Chem. 5-19-2004;52(10):2887-2889.
- Aggarwal, B. B. and Shishodia, S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann.N.Y Acad.Sci. 2004;1030:434-441.
- Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol.Res 2007;56(3):254-260.
- Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
- Aggarwal, B. B. and Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem.Pharmacol 5-14-2006;71(10):1397-1421.
- Hotta, M., Nakata, R., Katsukawa, M., Hori, K., Takahashi, S., and Inoue, H. Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression. J Lipid Res 2010;51(1):132-139.
- Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Tharakan, S. T., Sung, B., and Anand, P. Potential of spice-derived phytochemicals for cancer prevention. Planta Med 2008;74(13):1560-1569.
- Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol. 5-24-2006;105(3):449-455.
- Schone, F., Vetter, A., Hartung, H., Bergmann, H., Biertumpfel, A., Richter, G., Muller, S., and Breitschuh, G. Effects of essential oils from fennel (Foeniculi aetheroleum) and caraway (Carvi aetheroleum) in pigs. J Anim Physiol Anim Nutr (Berl) 2006;90(11-12):500-510.
- Gutierrez, J., Rodriguez, G., Barry-Ryan, C., and Bourke, P. Efficacy of plant essential oils against foodborne pathogens and spoilage bacteria associated with ready-to-eat vegetables: antimicrobial and sensory screening. J Food Prot. 2008;71(9):1846-1854.
- Vasudevan, K., Vembar, S., Veeraraghavan, K., and Haranath, P. S. Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J.Gastroenterol. 2000;19(2):53-56.
- Zidorn, C., Johrer, K., Ganzera, M., Schubert, B., Sigmund, E. M., Mader, J., Greil, R., Ellmerer, E. P., and Stuppner, H. Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. J Agric.Food Chem. 4-6-2005;53(7):2518-2523.
- Bub, S., Brinckmann, J., Cicconetti, G., and Valentine, B. Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled study. J Am.Med.Dir.Assoc. 2006;7(9):556-561.
- El Bardai, S., Lyoussi, B., Wibo, M., and Morel, N. Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clin Exp Hypertens. 2001;23(4):329-343.
- Kwon, Y. S., Choi, W. G., Kim, W. J., Kim, W. K., Kim, M. J., Kang, W. H., and Kim, C. M. Antimicrobial constituents of Foeniculum vulgare. Arch Pharm.Res 2002;25(2):154-157.
- Kim, D. H., Kim, S. I., Chang, K. S., and Ahn, Y. J. Repellent activity of constituents identified in Foeniculum vulgare fruit against Aedes aegypti (Diptera: Culicidae). J.Agric.Food Chem. 11-20-2002;50(24):6993-6996.
- Namavar, Jahromi B., Tartifizadeh, A., and Khabnadideh, S. Comparison of fennel and mefenamic acid for the treatment of primary dysmenorrhea. Int.J.Gynaecol.Obstet. 2003;80(2):153-157.
- Alexandrovich, I., Rakovitskaya, O., Kolmo, E., Sidorova, T., and Shushunov, S. The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study. Altern.Ther.Health Med. 2003;9(4):58-61.
- Javidnia, K., Dastgheib, L., Mohammadi, Samani S., and Nasiri, A. Antihirsutism activity of Fennel (fruits of Foeniculum vulgare) extract. A double-blind placebo controlled study. Phytomedicine. 2003;10(6-7):455-458.
- Choi, E. M. and Hwang, J. K. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia 2004;75(6):557-565.
- Liu, Z., Lu, C., and Chen, J. [Correlation comparison of uterotrophic assay and E-SCREEN assay for estrogenic activities]. Wei Sheng Yan.Jiu. 2004;33(4):458-460.
- Kim, S. I., Chang, K. S., Yang, Y. C., Kim, B. S., and Ahn, Y. J. Repellency of aerosol and cream products containing fennel oil to mosquitoes under laboratory and field conditions. Pest.Manag.Sci 2004;60(11):1125-1130.
- Murone, A. J., Stucki, P., Roback, M. G., and Gehri, M. Severe methemoglobinemia due to food intoxication in infants. Pediatr.Emerg.Care 2005;21(8):536-538.
- Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432.
- Joshi, H. and Parle, M. Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn. J Med Food 2006;9(3):413-417.
- Modaress, Nejad, V and Asadipour, M. Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea. East Mediterr.Health J 2006;12(3-4):423-427.
- Ozcan, M. M., Chalchat, J. C., Arslan, D., Ates, A., and Unver, A. Comparative essential oil composition and antifungal effect of bitter fennel (Foeniculum vulgare ssp. piperitum) fruit oils obtained during different vegetation. J Med Food 2006;9(4):552-561.
- Camacho-Corona, Mdel R., Ramirez-Cabrera, M. A., Santiago, O. G., Garza-Gonzalez, E., Palacios, Ide P., and Luna-Herrera, J. Activity against drug resistant-tuberculosis strains of plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases. Phytother.Res 2008;22(1):82-85.
- Wright, C. I., Van Buren, L., Kroner, C. I., and Koning, M. M. Herbal medicines as diuretics: a review of the scientific evidence. J Ethnopharmacol. 10-8-2007;114(1):1-31.
- Subehan, Zaidi, S. F., Kadota, S., and Tezuka, Y. Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. J Agric.Food Chem. 12-12-2007;55(25):10162-10167.
- Abramson, C. I., Wanderley, P. A., Wanderley, M. J., Silva, J. C., and Michaluk, L. M. The effect of essential oils of sweet fennel and pignut on mortality and learning in africanized honeybees (Apis mellifera L.) (Hymenoptera: Apidae). Neotrop.Entomol. 2007;36(6):828-835.
- Agarwal, R., Gupta, S. K., Agrawal, S. S., Srivastava, S., and Saxena, R. Oculohypotensive effects of foeniculum vulgare in experimental models of glaucoma. Indian J Physiol Pharmacol. 2008;52(1):77-83.
- LEVY, S. B. Bronchial asthma due to ingestion of fennel and fennel seed. Ann.Allergy 1948;6(4):415.
- Singh, B. and Kale, R. K. Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system. Food Chem.Toxicol. 2008;46(12):3842-3850.
- Zeller, A., Horst, K., and Rychlik, M. Study of the metabolism of estragole in humans consuming fennel tea. Chem.Res Toxicol. 2009;22(12):1929-1937.
- Picon, P. D., Picon, R. V., Costa, A. F., Sander, G. B., Amaral, K. M., Aboy, A. L., and Henriques, A. T. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. BMC.Complement Altern.Med. 2010;10:17.
- Ottolenghi, A., De Chiara, A., Arrigoni, S., Terracciano, L., and De Amici, M. [Diagnosis of food allergy caused by fruit and vegetables in children with atopic dermatitis]. Pediatr Med Chir 1995;17(6):525-530.
- Zahrani SH, Amjady MA, Mojab F, and et al. Clinical effects of foeniculum vulgare extract on systemic symptoms of primary dysmenorrhea in students of Shaheed Beheshti University in Tehran [Farsi]. SBMU Faculty of Nursing & Midwifery Quarterly (SBMU FAC NURS MIDWIFERY Q) 2005;15(49):14.
- Arya, S. Controlling angiotensin-converting-enzyme-inhibitor induced cough by fennel fruit. Indian J Pharmacol 1999;31(2):159.
- Dres, C, Johnson, C, and Loda, L. Enzymes and erythema reduction. SPC 1999;71(313):33.
- Platel K and Srinivasan K. A Study of the digestive stimulant action of select spices in experimental rats. Journal of Food Science and Technology 2001;38(4):358.
- Gilligan NP. The palliation of nausea in hospice and palliative care patients with essential oils of Pimpinella anisum (aniseed), Foeniculum vulgare var. dulce (sweet fennel), Anthemis nobilis (Roman chamomile) and Mentha x piperita (peppermint). International Journal of Aromatherapy (INT J AROMATHERAPY) 2005;15(4):163-167.
- Badgujar SB, Patel VV, Bandivdekar AH. Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. Biomed Res Int 2014;2014:842674.
- Yaralizadeh M, Abedi P, Najar S, Namjoyan F, Saki A. Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: a double-blind randomized placebo-controlled trial. Maturitas 2016;84:75-80.
- Bae J, Kim J, Choue R, Lim H. Fennel (Foeniculum vulgare) and fenugreek (Trigonella foenum-graecum) tea drinking suppresses subjective short-term appetite in overweight women. Clin Nutr Res 2015;4(3):168-74.
- Portincasa P, Bonfrate L, Scribano ML, et al. Curcumin and fennel essential oil improve symptoms and quality of life in patients with irritable bowel syndrome. J Gastrointestin Liver Dis. 2016 Jun;25(2):151-7.
- Abedi P, Najafian M, Yaralizadeh M, Namjoyan F. Effect of fennel vaginal cream on sexual function in postmenopausal women: A double blind randomized controlled trial. J Med Life. 2018;11(1):24-28.
- Harb T, Matsuyama M, David M, Hill RJ. Infant Colic-What works: A Systematic Review of Interventions for Breast-fed Infants. J Pediatr Gastroenterol Nutr. 2016;62(5):668-86.
- Rahimikian F, Rahimi R, Golzareh P, Bekhradi R, Mehran A. Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women: a randomized, triple-blind, placebo-controlled trial. Menopause. 2017;24(9):1017-1021.
- Trabace L, Tucci P, Ciuffreda L, et al. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015;174:396-402.
- Mahdavian M, Mirzaii Najmabadi K, Hosseinzadeh H, Mirzaeian S, Badiee Aval S, Esmaeeli H. Effect of the mixed herbal medicines extract (fennel, chamomile, and saffron) on menopause syndrome: a randomized controlled clinical trial. J Caring Sci. 2019;8(3):181-9.
- Denaxa D, Arkwright PD. Fennel as a cause of immediate hypersensitivity to toothpaste. Ann Allergy Asthma Immunol. 2020;125(1):99-100.
- Lee HW, Ang L, Lee MS, Alimoradi Z, Kim E. Fennel for reducing pain in primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2020;12(11):3438.
- Nadjarzadeh A, Ghadiri-Anari A, Ramezani-Jolfaie N, et al. Effect of hypocaloric high-protein, low-carbohydrate diet supplemented with fennel on androgenic and anthropometric indices in overweight and obese women with polycystic ovary syndrome: A randomized placebo-controlled trial. Complement Ther Med 2021;56:102633.
- Ghaffari P, Hosseininik M, Afrasiabifar A, et al. The effect of fennel seed powder on estradiol levels, menopausal symptoms, and sexual desire in postmenopausal women. Menopause 2020;27(11):1281-6.
- Alazadeh M, Azadbakht M, Niksolat F, et al. Effect of sweet fennel seed extract capsule on knee pain in women with knee osteoarthritis. Complement Ther Clin Pract 2020;40:101219.
- Shahrahmani H, Ghazanfarpour M, Shahrahmani N, Abdi F, Sewell RDE, Rafieian-Kopaei M. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis. J Complement Integr Med 2021;18(2):261-269.
- Azimi M, Niayesh H, Raeiszadeh M, Khodabandeh-Shahraki S. Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation: A double-blind randomized controlled trial. J Integr Med 2022;20(3):230-236.
- Bahman M, Hajimehdipoor H, Bioos S, Hashem-Dabaghian F, Afrakhteh M, Tansaz M. Effect of Aslagh Capsule, a Traditional Compound Herbal Product on Oligomenorrhea in Patients with Polycystic Ovary Syndrome: A Three-Arm, Open-label, Randomized, Controlled Trial. Galen Med J 2019;8:e1261.
- Mathew T, John SK, Javali M, Vasireddy M, Nadig R, Sarma GRK. Substance use related cluster headache: A case series. Headache 2022;62(7):908-910.
- Jenabi E, Khazaei S, Aghababaei S, Moradkhani S. Effect of Fennel-Valerian Extract on Hot Flashes and Sleep Disorders in Postmenopausal Women: A Randomized Trial. J Menopausal Med 2023;29(1):21-28.
- Aliakbari F, Naghdipour Mirsadeghi M, Hashemi E, Rahimi-Madiseh M, Mohammadi B. Effects of Combination Therapy with Bunium persicum and Foeniculum vulgare Extracts on Patients with Polycystic Ovary Syndrome. Adv Biomed Res 2022;11:74.
