Ellagic Acid
OTHER NAME(S): 3,4,3',4'-Hydroxyl-Benzopyranol[5,4,3-c,d,e][1]Benzopyrn-6-6'-Dione, Gallogen, Ellagic Acid, Ácido Elágico, Acide Ellagique
Overview
Ellagic acid is a naturally occurring substance. The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, cherries, and walnuts.
Ellagic acid is used for cancer, dark skin patches on the face (melasma), memory and thinking skills (cognitive function), diabetes, and many other purposes, but there is no good scientific evidence to support these uses.
Ellagic acid may bind to chemicals that cause cancer. It may also prevent the growth of cancer cells and improve the safety and efficacy of some cancer drugs. However, ellagic acid is poorly absorbed and is also eliminated quickly from the body. These characteristics may limit its usefulness as a medicine.
Ellagic acid may bind to chemicals that cause cancer. It may also prevent the growth of cancer cells and improve the safety and efficacy of some cancer drugs. However, ellagic acid is poorly absorbed and is also eliminated quickly from the body. These characteristics may limit its usefulness as a medicine.
Uses
We currently have no information for Ellagic Acid overview.
Side Effects
When taken by mouth: Ellagic acid is POSSIBLY SAFE when taken appropriately for up to 3 months. There isn't enough reliable information to know if ellagic acid is safe or what the side effects might be when used long-term.
When applied to the skin: Ellagic acid is POSSIBLY SAFE when used for up to 6 months. There isn't enough reliable information to know if ellagic acid is safe or what the side effects might be when used long-term.
Precautions
When taken by mouth: Ellagic acid is POSSIBLY SAFE when taken appropriately for up to 3 months. There isn't enough reliable information to know if ellagic acid is safe or what the side effects might be when used long-term.
When applied to the skin: Ellagic acid is POSSIBLY SAFE when used for up to 6 months. There isn't enough reliable information to know if ellagic acid is safe or what the side effects might be when used long-term.
Pregnancy and breast-feeding: There isn't enough reliable information to know if ellagic acid is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for diabetes (Antidiabetes drugs) interacts with Ellagic AcidEllagic acid might lower blood sugar levels. Taking ellagic acid along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Dosing
The appropriate dose of ellagic acid depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ellagic acid. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Anderson KJ, Teuber SS, Gobeille A, et al. Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J Nutr 2001;131:2837-42.
- Barch DH, Rundhaugen LM, Stoner GD, et al. Structure-function relationships of the dietary anticarcinogen ellagic acid. Carcinogenesis 1996;17:265-9..
- Constantinou A, Stoner GD, Mehta R, et al. The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro. Nutr Cancer 1995;23:121-30..
- Xu Y, Deng JZ, Ma J, et al. DNA damaging activity of ellagic acid derivatives. Bioorg Med Chem 2003;11:1593-6..
- Mullen W, Stewart AJ, Lean ME, et al. Effect of freezing and storage on the phenolics, ellagitannins, flavonoids, and antioxidant capacity of red raspberries. J Agric Food Chem 2002;508:5197-201..
- Priyadarsini KI, Khopde SM, Kumar SS, Mohan H. Free radical studies of ellagic acid, a natural phenolic antioxidant. J Agric Food Chem 2002;50:2200-6.
- Dell'Agli M, Parapini S, Basilico N, et al. In vitro studies on the mechanism of action of two compounds with antiplasmodial activity: ellagic acid and 3,4,5-trimethoxyphenyl(6'-O-aalloyl)-beta-D-glucopyranoside. Planta Med 2003;69:162-4.
- Ertam I, Mutlu B, Unal I, Alper S, Kivçak B, Ozer O. Efficiency of ellagic acid and arbutin in melasma: a randomized, prospective, open-label study. J Dermatol. 2008;35(9):570-4.
- Dahl A, Yatskayer M, Raab S, Oresajo C. Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone. J Drugs Dermatol. 2013;12(1):52-8.
- Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate. Eur Urol. 2005;47(4):449-54
- Le Donne M, Lentini M, Alibrandi A, et al. Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial. J Funct Food 2017;35:549-54.
- Liu Y, Yu S, Wang F, et al. Chronic administration of ellagic acid improved the cognition in middle-aged overweight men. Appl Physiol Nutr Metab. 2018;43(3):266-73.
- Zhou B, Li Q, Wang J, Chen P, Jiang S. Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Food Chem Toxicol. 2019;123:16-27.
- Zhong C, Qiu S, Li J, et al. Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma. Phytomedicine. 2019;59:152921.
- Serretta V, Berardinis E, Simonato A, et al. A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis. Urologia. 2021 Jun 2:3915603211022285.
- Ghadimi M, Foroughi F, Hashemipour S, et al. Randomized double-blind clinical trial examining the Ellagic acid effects on glycemic status, insulin resistance, antioxidant, and inflammatory factors in patients with type 2 diabetes. Phytother Res 2021;35(2):1023-1032.
- Kazemi M, Lalooha F, Nooshabadi MR, Dashti F, Kavianpour M, Haghighian HK. Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome. J Ovarian Res 2021;14(1):100.
- Ghadimi M, Foroughi F, Hashemipour S, et al. Decreased insulin resistance in diabetic patients by influencing Sirtuin1 and Fetuin-A following supplementation with ellagic acid: a randomized controlled trial. Diabetol Metab Syndr 2021;13(1):16.