Collagen Type I (native)
OTHER NAME(S): Atelocollagen type I, Collagen Type I, Type I Collagen, Native Collagen Type I, Native Type I Collagen, Undenatured Collagen Type I, Undenatured Type I Collagen, Collagen Type I, Collagen Type I, Collagen Type 1, Colágeno tipo I (nativo), Collagène de Type I (Natif)
Overview
Collagen type I (native) is a protein found in skin, tendons, ligaments, and bone. Most collagen type I in supplements comes from cows.
Collagen type I plays a major role in wound healing. But it's not clear if taking collagen type I by mouth has any beneficial effects.
People most commonly use collagen type I to support healthy skin, hair, and nails. It's also been used for osteoarthritis, scleroderma, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse collagen type I (native) with collagen type II (native), collagen peptides, or gelatin. These are not the same.
Uses
We currently have no information for Collagen Type I (native) overview.
Side Effects
When taken by mouth: Collagen type I is possibly safe when used short-term. Doses of 500 mcg daily have been safely used for up to 12 months.
When applied to the skin: There isn't enough reliable information to know if collagen type I is safe or what the side effects might be.
Precautions
When taken by mouth: Collagen type I is possibly safe when used short-term. Doses of 500 mcg daily have been safely used for up to 12 months.
When applied to the skin: There isn't enough reliable information to know if collagen type I is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if collagen type I is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
We currently have no information for Collagen Type I (native) overview.
Dosing
There isn't enough reliable information to know what an appropriate dose of collagen type I (native) might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Also note that most collagen type I in supplements comes from cows, but it can also come from other sources such as eggshells. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Trentham DE. Oral tolerization as a treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998;24:525-36.
- Wong M, Hendrix MJ, von der Mark K, Little C, Stern R. Collagen in the Egg Shell Membranes of the Hen. Dev Biol. 1984;104(1);28-36.
- León-López A, Morales-Peñaloza A, Martínez-Juárez VM, et al. Hydrolyzed Collagen-Sources and Applications. Molecules. 2019;24(22):4031.
- Postlethwaite AE, Wong WK, Clements P, et al. A multicenter, randomized, double-blind, placebo-controlled trial of oral type I collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. oral type I collagen does not improve skin in all patients, but may improve skin in late-phase disease. Arthritis Rheum. 2008;58(6):1810-22.
- McKown KM, Carbone LD, Bustillo J, Seyer JM, Kang AH, Postlethwaite AE. Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen. Arthritis Rheum. 2000;43(5):1054-61.
- Atamas SP, Luzina IG, Ingels J, et al. Stimulation with type I collagen induces changes in gene expression in peripheral blood mononuclear cells from patients with diffuse cutaneous systemic sclerosis (scleroderma). Clin Exp Immunol. 2010;161(3):426-35.
- Stancík R, Zvarka J, Hlavác M, Kubinec V, Rovenský J. Collagen type I in the treatment of painful osteoarthritis of the knee. Reumatologia. 2012;50(5):390-6.
- Méndez-Flores S, Priego-Ranero Á, Azamar-Llamas D, et al. Effect of polymerised type I collagen on hyperinflammation of adult outpatients with symptomatic COVID-19. Clin Transl Med 2022;12(3):e763.