Bovine Cartilage
OTHER NAME(S): Antitumor Angiogenesis Factor (anti-TAF), Bovine Tracheal Cartilage (BTC), Cartilage Trachéal de Bovins, Cartílago Bovino, Catrix, Catrix-S, Collagen Bovine, Collagène Bovin, Glycosaminoglycan Polysulphuric Acid Complex, Processed Bovine Cartilage, Psoriacin, Psoriacin-T, Rumalon, None., Bovine Tracheal Cartilage, Bovine Trachea Cartilage, Cartílago bovino, Cartilage bovin
Overview
Cartilage is a substance in the body that provides structural support. Bovine cartilage comes from cows (bovine). It's used in dietary supplements.
Bovine cartilage might work by providing chemicals needed for rebuilding cartilage in people with osteoarthritis. It might also help reduce swelling and help wounds heal.
People use bovine cartilage for osteoarthritis, wound healing, recovery from laser skin therapy, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse bovine cartilage with shark cartilage or chondroitin sulfate. These are not the same.
Uses
We currently have no information for Bovine Cartilage overview.
Side Effects
When taken by mouth: Bovine cartilage is possibly safe. It's been used safely for up to 5 years. Side effects might include diarrhea and stomach upset.
There is some concern about catching animal-borne diseases from products that come from animals. But there aren't any reports of diseases being transmitted through cartilage products.
When applied to the skin: Bovine cartilage is possibly safe for most people.
Precautions
When taken by mouth: Bovine cartilage is possibly safe. It's been used safely for up to 5 years. Side effects might include diarrhea and stomach upset.
There is some concern about catching animal-borne diseases from products that come from animals. But there aren't any reports of diseases being transmitted through cartilage products.
When applied to the skin: Bovine cartilage is possibly safe for most people.
Pregnancy and breast-feeding: There isn't enough reliable information to know if bovine cartilage is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
We currently have no information for Bovine Cartilage overview.
Dosing
There isn't enough reliable information to know what an appropriate dose of bovine cartilage might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: http://www.cfsan.fda.gov/~dms/dspltr05.html.
- Prudden JF, Balassa LL. The biological activity of bovine cartilage preparations. Clinical demonstration of their potent anti-inflammatory capacity with supplementary notes on certain relevant fundamental supportive studies. Semin Arthritis Rheum 1974;3:287-321.
- Prudden JF. The treatment of human cancer with agents prepared from bovine cartilage. J Biol Response Mod 1985;4:551-84.
- Durk H, Haase K, Saal J, et al. Nephrotic syndrome after injections of bovine cartilage and marrow extract. [letter] Lancet 1989;1:614.
- Pavelka K, Gatterova J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of a glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000;8:335-42.
- Klein, R., Becker, E. W., Berg, P. A., and Bernau, A. Immunomodulatory properties of rumalon, a glycosaminoglycan peptide complex, in patients with osteoarthritis: activation of T helper cell type 2 cytokines and antigen-specific IgG4 antigen-specific igG4 antibodies. J.Rheumatol. 2000;27(2):448-454.
- Liu, N., Lapcevich, R. K., Underhill, C. B., Han, Z., Gao, F., Swartz, G., Plum, S. M., Zhang, L., and Green, S. J. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth. Cancer Res 2-1-2001;61(3):1022-1028.
- Tanzi, E. L. and Perez, M. The effect of a mucopolysaccharide-cartilage complex healing ointment on Er:YAG laser resurfaced facial skin. Dermatol Surg 2002;28(4):305-308.
- Shukunami, C., Oshima, Y., and Hiraki, Y. Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues. Biochem Biophys Res Commun. 7-29-2005;333(2):299-307.
- Brandt, R., Hedlof, E., Asman, I., Bucht, A., and Tengblad, A. A convenient radiometric assay for hyaluronan. Acta Otolaryngol.Suppl 1987;442:31-35.
- Durk, H., Haase, K., Saal, J., Becker, W., and Berg, P. A. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 3-18-1989;1(8638):614.
- Schacht, E. and Roetz, R. Nephrotic syndrome after injections of bovine cartilage and marrow extract. Lancet 4-29-1989;1(8644):963.
- Berg, P. A., Durk, H., Saal, J., and Hopf, G. Bovine cartilage and marrow extract. Lancet 6-3-1989;1(8649):1275.
- Durie, B. G., Soehnlen, B., and Prudden, J. F. Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay. J.Biol.Response Mod. 1985;4(6):590-595.
- Saikawa, I., Hotokebuchi, T., Miyahara, H., Tokito, T., Maeda, T., Arita, C., and Sugioka, Y. High-density proteoglycan induces specific suppression of adjuvant-induced arthritis in rats. Clin Exp Immunol 1994;95(3):424-429.
- Bunning, R. A. D., Murphy, G., Kumar, S., Phillips, P., and Reynolds, J. Metalloproteinase inhibitors from bovine cartilage and body fluids. European Journal of Biochemistry 1984;139(1):75-80.
- Hiraki, Y., Kato, Y., Inoue, H., and Suzuki, F. Stimulation of DNA synthesis in quiescent rabbit chondrocytes in culture by limited exposure to somatomedin-like growth factors. European Journal of Biochemistry 1986;158(2):333-337.
- Prudden JF, Nishihara G, Baker L. The acceleration of wound healing with cartilage. I. Surg Gynecol Obstet 1957;105(3):283-6.
- Paulette RE, Prudden JF. Studies on the acceleration of wound healing with cartilage. II. Histological observation. Surg Gynecol Obset 1959;108(4):406-8.
- Schwartz MS, Gump F, Prudden JF. The influence of cartilage on the time course of wound healing. Surg Forum 1960;10:308-11.
- Houck JC, Jacob RA, Deangelo L, Vickers K. The inhibition of inflammation and the acceleration of tissue repair by cartilage powder. Surgery 1962;51:632-8.
- Prudden JF, Inoue T, Ocampo L. Subcutaneous cartilage pellets. Their effect on wound tensile strength. Arch Surg 1962;85:245-6.
- Prudden JF, Othmar G, Allen B. The acceleration of wound healing. Use of parenteral injections of a saline cartilage extract, with a note on the evaluations of electrophoretically separated fractions of the extract by tissue culture. Arch Surg 1963;86(1):157-61.
- Prudden JF. Wound healing produced by cartilage preparations. The enhancement of acceleration, with a report on the use of a cartilage preparation in clinically chronic ulcers and in primarily closed human surgical incisions. Arch Surg 1964;89:1046-59.
- Prudden JF, Allen J. The clinical acceleration of healing with a cartilage preparation: a controlled study. JAMA 1965;192:352-6.
- Sabo JC, Oberlander L, Enquist IF. Acceleration of open wound healing by cartilage. Arch Surg 1965;90:414-7.
- Allen J, Prudden JF. Histological response to a cartilage powder preparation in a controlled human study. Am J Surg 1966; 112(6):888-91.
- Prudden JF, Wolarsky ER, Balassa L. The acceleration of healing. Surg Gynecol Obstet 1969;128(6):1321-6.
- Prudden JF, Migel P, Hanson P, et al. The discovery of a potent pure chemical wound-healing accelerator. Am J Surg 1970;119(5):560-4.
- Pavelka K, Gatterova J, Gollerova V, et al. A 5-year randomized controlled, double-blind study of glycosaminoglycan polysulphuric acid complex (Rumalon) as a structure modifying therapy in osteoarthritis of the hip and knee. Osteoarthritis Cartilage 2000;8(5):335-42.
- Katona G. A clinical trial of glycosaminoglycan-peptide complex ('Rumalon') in patients with osteoarthritis of the knee. Curr Med Res Opin 1987;10(9):625-33.
- Gramajo RJ, Cutroneo EJ, Fernandez DE, et al. A single-blind, placebo-controlled study of glycosaminoglycan-peptide complex ('Rumalon') in patients with osteoarthritis of the hip or knee. Curr Med Res Opin 1989;11(6):366-73.