Atractylodes
OTHER NAME(S): AMK, ATR, Atractylenolide, Atractylénolide, Atractylode Blanc, Atractylode Gris, Atractylodis Radix, Bai Zhu, Bai-Zhu Atractylodes, Byaki-Jutsu, Byakujutsu, Cang Zhu, Chang Zhe, Jutsu, Khod Kha Mao, Largehead Atractylodes, Paekch'ul, Red Atractylodes, Rhizoma Atractylodis, Rhizoma Atractylodis Macroce, Rhizoma Atractylodis Macrocephalae, Rhizome d'Atractylode, So-Jutsu, White Atractylodes, White Atractylodis, Atractylodes lancea, Atractylodes chinensis, Atractylis lancea, Atractylodes ovata, Atractylis ovata, Atractylodes japonica, Atractylodes macrocephala, Bai-Zhu, Cangzhu, Atractolydes Macrocephala, Atractilodes
Overview
Atractylodes is a group of flowering plants native to eastern Asia. Its roots are used in traditional Chinese medicine (TCM).
Atractylodes contains chemicals that might help with digestion and reduce pain and swelling. It also contains chemicals that might prevent cancer cells from growing.
People use atractylodes for stomach pain, common cold, lung cancer, obesity, and many other conditions, but there is no good scientific evidence to support these uses.
Uses
We currently have no information for Atractylodes overview.
Side Effects
When taken by mouth: There isn't enough reliable information to know if atractylodes is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if atractylodes is safe or what the side effects might be.
Pregnancy: Atractylodes is possibly unsafe when taken by mouth during pregnancy. In animals, it has caused death or harm in unborn babies. Stay on the safe side and avoid use.
Breast-feeding: There isn't enough reliable information to know if atractylodes is safe to use when breast-feeding. Stay on the safe side and avoid use.
Allergy to ragweed and related plants: Atractylodes may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others.
Bleeding disorders: Atractylodes might slow blood clotting. Taking atractylodes might increase the risk of bruising and bleeding in people with bleeding disorders.
Surgery: Atractylodes might slow blood clotting. This might cause extra bleeding during and after surgery. Stop using atractylodes at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Hexobarbital interacts with AtractylodesAtractylodes might increase the effects of hexobarbital. Taking atractylodes along with hexobarbital might cause too much sleepiness.
- Medications for estrogen sensitive cancers (Aromatase inhibitors) interacts with AtractylodesSome types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Medications for estrogen sensitive cancers help decrease estrogen in the body. Atractylodes might also decrease estrogen in the body. Taking atractylodes along with medications for estrogen-sensitive cancers might decrease estrogen in the body too much.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with AtractylodesAtractylodes might slow blood clotting. Taking atractylodes along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Minor Interaction
Be watchful with this combination
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with AtractylodesSome medications are changed and broken down by the liver. Atractylodes might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with AtractylodesSome medications are changed and broken down by the liver. Atractylodes might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Dosing
There isn't enough reliable information to know what an appropriate dose of atractylodes might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Kitajima J, Kamoshita A, Ishikawa T, et al. Glycosides of Atractylodes ovata. Chem Pharm Bull (Tokyo) 2003;51:1106-8.
- Kitajima J, Kamoshita A, Ishikawa T, et al. Glycosides of Atractylodes lancea. Chem Pharm Bull (Tokyo) 2003;51:673-8.
- Kitajima J, Kamoshita A, Ishikawa T, et al. Glycosides of Atractylodes japonica. Chem Pharm Bull (Tokyo) 2003;51:152-7.
- Nakai Y, Kido T, Hashimoto K, et al. Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying. J Ethnopharmacol 2003;84:51-5.
- Nogami M, Moriura T, Kubo M, Tani T. Studies on the origin, processing and quality of crude drugs. II. Pharmacological evaluation of the Chinese crude drug "zhu" in experimental stomach ulcer. (2). Inhibitory effect of extract of Atractylodes lancea on gastric secretion. Chem Pharm Bull (Tokyo) 1986;34:3854-60.
- Yamahara J, Matsuda H, Huang Q, Li Y, Fujimura H. Intestinal motility enhancing effect of Atractylodes lancea rhizome. J Ethnopharmacol 1990;29:341-4.
- Prieto JM, Recio MC, Giner RM, et al. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol 2003;55:1275-82.
- Jang MH, Shin MC, Kim YJ, et al. Atractylodes japonica suppresses lipopolysaccharide-stimulated expressions of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 macrophages. Biol Pharm Bull 2004;27:324-7.
- Yu KW, Kiyohara H, Matsumoto T, et al. Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea. Planta Med 1998;64:714-9.
- Resch M, Heilmann J, Steigel A, Bauer R. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta Med 2001;67:437-42.
- Inagaki K, Komatsu Y, Sasaki H, et al. Acidic polysaccharides from rhizomes of Atractylodes lancea as protective principle in Candida-infected mice. Planta Med 2001;67:428-31.
- Min BS, Kim YH, Tomiyama M, et al. Inhibitory effects of Korean plants on HIV-1 activities. Phytother Res 2001;15:481-6.
- Wang CC, Chen LG, Yang LL. Cytotoxic activity of sesquiterpenoids from Atractylodes ovata on leukemia cell lines. Planta Med 2002;68:204-8.
- Kamei T, Kumano H, Iwata K, et al. The effect of a traditional Chinese prescription for a case of lung carcinoma. J Altern Complement Med 2000;6:557-9.
- Liambo W, Baotian C, Rengao Y, Huiqun L. Treatment of complications due to peritoneal dialysis for chronic renal failure with traditional Chinese medicine. J Trad Chinese Med 1999;19:3-9.
- Sakurai T, Sugawara H, Saito K, Kano Y. Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species. Biol Pharm Bull 1994;17:1364-8.
- Resch M, Steigel A, Chen ZL, Bauer R. 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. J Nat Prod 1998;61:347-50.
- Liu Y, Jia Z, Dong L, et al. A randomized pilot study of atractylenolide I on gastric cancer cachexia patients. Evid Based Complement Alternat Med 2008;5:337-44.
- Kim HK, Yun YK, Ahn YJ. Toxicity of atractylon and atractylenolide III identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem 2007;55:6027-31.
- Tsuneki H, Kobayashi S, Sekizaki N, et al. Antiangiogenic activity of beta-eudesmol in vitro and in vivo. Eur J Pharmacol 2005;512:105-15.
- Li CQ, He LC, Jin JQ. Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages. Phytother Res 2007;21:347-53.
- Wang KT, Chen LG, Yang LL, et al. Analysis of the sesquiterpenoids in processes Atractylodes rhizome. Chem Pharm Bull 2007;55:50-6.
- Lee JC, Lee KY, Son YO, et al. Stimulating effects on mouse splenocytes of glycoproteins from the herbal medicine Atractylodes macrocephala Koidz. Phytomedicine 2007;14:390-5.
- Wang CC, Lin SY, Cheng HC, Hou WC. Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells. Food Chem Toxicol 2006;44:1308-15.
- Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202.
- Han Y, Jung HW, Park YK. The roots of Atractylodes japonica Koidzumi promote adipogenic differentiation via activation of the insulin signaling pathway in 3T3-L1 cells. BMC Complement Altern Med. 2012 Sep 14;12:154.
- Jeong SI, Kim SY, Kim SJ, Hwang BS, Kwon TH, Yu KY, Hang SH, Suzuki K, Kim KJ. Antibacterial activity of phytochemicals isolated from Atractylodes japonica against methicillin-resistant Staphylococcus aureus. Molecules. 2010 Oct 21;15(10):7395-402.
- Jiang H, Shi J, Li Y. Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules. 2011 Apr 14;16(4):3146-51.
- Koonrungsesomboon N, Na-Bangchang K, Karbwang J. Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 2014 Jun;7(6):421-8.
- Li L, Tang LY, Man GC, Yeung BH, Lau CB, Leung PC, Wang CC. Potential reproductive toxicity of Largehead Atractylodes Rhizome, the most commonly used Chinese medicine for threatened miscarriage. Hum Reprod. 2011 Dec;26(12):3280-8.
- 94305 Wang KT, Chen LG, Chou DS, Liang WL, Wang CC. Anti-Oxidative Abilities of Essential Oils from Atractylodes ovata Rhizome. Evid Based Complement Alternat Med. 2011;2011:204892.
- Zhou J, Qu F, Yu Y. Chemical and ecological evaluation of a genuine Chinese medicine: Atractylodes macrocephala Koidz. Afr J Tradit Complement Altern Med.2011;8(4):405-11.
- Na-Bangchang K, Kulma I, Plengsuriyakarn T, et al. Phase I clinical trial to evaluate the safety and pharmacokinetics of capsule formulation of the standardized extract of Atractylodes lancea. J Tradit Complement Med 2021;11(4):343-355.
- Kulma I, Panrit L, Plengsuriyakarn T, Chaijaroenkul W, Warathumpitak S, Na-Bangchang K. A randomized placebo-controlled phase I clinical trial to evaluate the immunomodulatory activities of Atractylodes lancea (Thunb) DC. in healthy Thai subjects. BMC Complement Med Ther 2021;21(1):61.
- Park YJ, Seo MG, Cominguez DC, Han I, An HJ. Atractylodes chinensis Water Extract Ameliorates Obesity via Promotion of the SIRT1/AMPK Expression in High-Fat Diet-Induced Obese Mice. Nutrients 2021;13(9):2992.
- Qian X, Jiang Y, Luo Y, Jiang Y. The Anti-hyperuricemia and Anti-inflammatory Effects of Atractylodes Macrocephala in Hyperuricemia and Gouty Arthritis Rat Models. Comb Chem High Throughput Screen 2022.
- Cheng H, Zhang D, Wu J, et al. Atractylodes macrocephala Koidz. volatile oil relieves acute ulcerative colitis via regulating gut microbiota and gut microbiota metabolism. Front Immunol 2023;14:1127785.
- Matsumoto H, Matsumoto A, Miyata S, et al. The Effect of Japanese Herbal Medicines (Kampo) Goreisan and Saireito on the Prevention of Recurrent Chronic Subdural Hematoma: A Prospective Randomized Study. Neurosurgery 2023.
- Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614.
- Zhang B, Bu L, Tian H, et al. Effects of Atractylodes lancea extracts on intestinal flora and serum metabolites in mice with intestinal dysbacteriosis. Proteome Sci 2023;21(1):5.
