Try for free

Andarine

Andarine

OTHER NAME(S): (S)-3-(4-acetylamino-phenoxy)-2-hydroxy2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide, Acetamidoxolutamide, Androxolutamide, GTx-007, SARM-S4, S4, Andarine, Andarina

Overview

Andarine is an investigational drug that has not yet been approved by the US Food and Drug Administration (FDA). It is part of a class of drugs called selective androgen receptor modulators (SARMs). Some supplement companies have included andarine in products for bodybuilding. The FDA considers supplements containing andarine to be illegal.

People use andarine to improve athletic performance and for conditions such as involuntary weight loss in people who are very ill (cachexia or wasting syndrome), osteoporosis, and prostate health, but there is no good scientific evidence to support these uses. Using andarine can also be unsafe.

Andarine attaches to proteins in the body known as androgen receptors. When andarine binds to these receptors, it tells the muscles and bones in the body to grow. Unlike some other chemicals that bind to androgen receptors, such as steroids, andarine doesn't seem to cause as many side effects in other parts of the body.

Andarine attaches to proteins in the body known as androgen receptors. When andarine binds to these receptors, it tells the muscles and bones in the body to grow. Unlike some other chemicals that bind to androgen receptors, such as steroids, andarine doesn't seem to cause as many side effects in other parts of the body.

References
  1. Selective Androgen Receptor Modulators (SARMs) - A Prohibited Class of Anabolic Agents. U.S. Anti-Doping Agency, November 18, 2015. https://www.usada.org/selective-androgen-receptor-modulators-sarms-prohibited-class-anabolic-agencts/. Accessed: August 30, 2017.
  2. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical composition and labeling of substances marketed as selective androgen receptor modulators and sold via the internet. JAMA 2017;318(20):2004-10.
  3. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
  4. WADA. What is prohibited. 2019 list of prohibited substances and methods. Available at: https://www.wada-ama.org/en/content/what-is-prohibited/.
  5. Grata E, Perrenoud L, Saugy M, Baume N. SARM-S4 and metabolites detection in sports drug testing: a case report. Forensic Sci Int. 2011;213(1-3):104-8.
  6. Kearbey JD, Gao W, Narayanan R, et al. Selective androgen receptor modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007;24(2):328-35.
  7. Gao W, Reiser PJ, Coss CC, et al. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005;146(11):4887-97.
  8. Kearbey JD, Wu D, Gao W, Miller DD, Dalton JT. Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator. Xenobiotica. 2004;34(3):273-80.
  9. Yin D, Gao W, Kearbey JD, et al. Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther. 2003;304(3):1334-40.
  10. Garg N, Hansson A, Knych HK, et al. Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control. Org Biomol Chem. 2018;16(5):698-702.
  11. Thevis M, Geyer H, Kamber M, Schänzer W. Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product. Drug Test Anal. 2009;1(8):387-92.
  12. 2019-20 NCAA Banned Drugs List. National Collegiate Athletic Association (NCAA). https://www.ncaa.org/sport-science-institute/topics/2019-20-ncaa-banned-substances. Accessed: August 22, 2019