Yerba Mate
OTHER NAME(S): Chimarrao, Green Mate, Hervea, Ilex, Jesuit's Brazil Tea, Jesuit's Tea, Maté, Maté Folium, Paraguay Tea, St. Bartholemew's Tea, Thé de Saint Barthélémy, Thé des Jésuites, Thé du Brésil, Thé du Paraguay, Yerbamate, Ilex paraguariensis, Jesuit's Brazil Tea, Yerba Matte, Yerba Maté
Overview
Yerba mate, also called mate, is a popular drink similar to coffee or tea. It's made from the leaves of the Ilex paraguariensis plant and contains caffeine.
Caffeine and other chemicals in yerba mate can stimulate the brain, heart, muscles lining blood vessels, and other parts of the body.
People use yerba mate for athletic performance, memory and thinking skills, headache, fatigue, and many other conditions, but there is no good scientific evidence to support these uses.
Using yerba mate long-term, especially with alcohol or nicotine, has been linked to an increased risk of various types of cancer, including stomach, kidney, lung, and mouth cancer. Don't confuse yerba mate with caffeine or other caffeine sources, such as green tea, black tea, and guarana.
Uses
We currently have no information for Yerba Mate overview.
Side Effects
When taken by mouth: Yerba mate is possibly safe when used for up to 12 weeks. Yerba mate contains caffeine, which can cause side effects such as insomnia, upset stomach, increased heart rate, and others.
Yerba mate is possibly unsafe when taken in large amounts or for long periods of time. Drinking large amounts of yerba mate (1-2 liters daily) for a long time increases the risk of some types of cancer. This risk is especially high for people who smoke or drink alcohol. Consuming more than 10 cups daily might also increase the risk of serious caffeine-related side effects.
Precautions
When taken by mouth: Yerba mate is possibly safe when used for up to 12 weeks. Yerba mate contains caffeine, which can cause side effects such as insomnia, upset stomach, increased heart rate, and others.
Yerba mate is possibly unsafe when taken in large amounts or for long periods of time. Drinking large amounts of yerba mate (1-2 liters daily) for a long time increases the risk of some types of cancer. This risk is especially high for people who smoke or drink alcohol. Consuming more than 10 cups daily might also increase the risk of serious caffeine-related side effects.
Pregnancy: Yerba mate is possibly unsafe when taken by mouth during pregnancy. Yerba mate seems to increase the risk of getting cancer. It's not known whether that risk is transferred to the fetus. Yerba mate also contains caffeine. Avoid consuming more than 300 mg of caffeine daily (about 6 cups of yerba mate) when pregnant. High doses of caffeine have been linked with miscarriage, premature delivery, and low birth weight.
Breast-feeding: Yerba mate is possibly unsafe when taken by mouth while breast-feeding. It's not known whether the cancer-causing chemicals in yerba mate pass into breast milk. Also, the caffeine in yerba mate might cause irritability and increased bowel movements in nursing infants.
Children: Yerba mate is possibly unsafe when taken by mouth in children. Yerba mate is linked with an increased risk of some types of cancer.
Alcohol use disorder: Consuming yerba mate with large amounts of alcohol long-term seems to increase the risk of cancer.
Anxiety disorders: The caffeine in yerba mate might make anxiety disorders worse.
Bleeding disorders: Caffeine might slow clotting. The caffeine in yerba mate might make bleeding disorders worse. But so far, this effect has not been reported in people.
Heart conditions: Caffeine in yerba mate can cause irregular heartbeats in certain people. If you have a heart condition, use yerba mate in moderation.
Diabetes: The caffeine in yerba mate might affect blood sugar. Use yerba mate with caution if you have diabetes.
Diarrhea: Yerba mate contains caffeine. The caffeine in yerba mate, especially when taken in large amounts, can worsen diarrhea.
Seizures: Yerba mate contains caffeine. High doses of caffeine might cause seizures or decrease the effects of drugs used to prevent seizures. If you have ever had a seizure, don't take high doses of caffeine.
Glaucoma: Using yerba mate increases the pressure inside the eye due to the caffeine it contains. The increase in pressure occurs within 30 minutes and lasts for at least 90 minutes. If you have glaucoma, discuss your use of yerba mate with your healthcare provider.
High blood pressure: Yerba mate contains caffeine. Drinking caffeine might increase blood pressure in people with high blood pressure. However, this effect might be less in people who drink caffeine regularly.
Irritable bowel syndrome (IBS): Yerba mate contains caffeine. The caffeine in yerba mate, especially when taken in large amounts, can worsen diarrhea and might worsen symptoms of IBS.
Weak bones (osteoporosis): Yerba mate contains caffeine. Caffeine can increase the amount of calcium that is flushed out in the urine. This might weaken bones. If you have osteoporosis, don't drink more than 6 cups of yerba mate daily. If you are generally healthy and get enough calcium from your food or supplements, drinking about 8-10 cups of yerba mate daily doesn't seem to increase the risk of getting osteoporosis.
Smoking: Consuming yerba mate and also smoking long-term seems to increase the risk of getting cancer.
Interactions
Moderate Interaction
Be cautious with this combination
- Clozapine (Clozaril) interacts with Yerba MateThe body breaks down clozapine to get rid of it. The caffeine in yerba mate seems to decrease how quickly the body breaks down clozapine. Taking yerba mate along with clozapine can increase the effects and side effects of clozapine.
- Dipyridamole (Persantine) interacts with Yerba MateYerba mate contains caffeine. The caffeine in yerba mate might block the effects of dipyridamole. Dipyridamole is often used by doctors to do a test on the heart called a cardiac stress test. Stop consuming yerba mate or other caffeine-containing products at least 24 hours before a cardiac stress test.
- Verapamil (Calan, others) interacts with Yerba MateThe body breaks down the caffeine in yerba mate to get rid of it. Verapamil can decrease how quickly the body gets rid of caffeine. Drinking yerba mate and taking verapamil can increase the risk of caffeine side effects.
- Ephedrine interacts with Yerba MateStimulant drugs speed up the nervous system. The caffeine in yerba mate is a stimulant drug. Ephedrine is also a stimulant drug. Taking caffeine with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.
- Stimulant drugs interacts with Yerba MateStimulants, such as amphetamines and cocaine, speed up the nervous system. By speeding up the nervous system, stimulant medications can increase blood pressure and speed up the heartbeat. Yerba mate contains caffeine. Caffeine can also speed up the nervous system. Taking yerba mate along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
- Adenosine (Adenocard) interacts with Yerba MateYerba mate contains caffeine. The caffeine in yerba mate might block the effects of adenosine, which is used to do a test called a cardiac stress test. Stop consuming yerba mate or other caffeine-containing products at least 24 hours before a cardiac stress test.
- Lithium interacts with Yerba MateThe caffeine in yerba mate can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping yerba mate too quickly can increase the side effects of lithium.
- Medications for depression (MAOIs) interacts with Yerba MateYerba mate contains caffeine. There is some concern that caffeine can interact with certain medications, called MAOIs. If caffeine is taken with these medications, it might increase the risk for serious side effects including fast heartbeat and very high blood pressure. Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
- Medications for diabetes (Antidiabetes drugs) interacts with Yerba MateYerba mate contains caffeine. Caffeine can either increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. Taking some medications for diabetes along with caffeine might change the effects of the diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Yerba MateYerba mate contains caffeine. Caffeine might slow blood clotting. Taking yerba mate along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
- Nicotine interacts with Yerba MateYerba mate contains caffeine. Caffeine can stimulate the heart. Nicotine can also stimulate the heart. Taking caffeine with nicotine might cause too much stimulation and cause heart problems, such as increased heart rate or blood pressure.
- Pentobarbital (Nembutal) interacts with Yerba MateThe stimulant effects of the caffeine in yerba mate can block the sleep-producing effects of pentobarbital.
- Phenylpropanolamine interacts with Yerba MateYerba mate contains caffeine. Caffeine can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking yerba mate and phenylpropanolamine together might cause too much stimulation and increase heartbeat and blood pressure and cause nervousness.
- Riluzole (Rilutek) interacts with Yerba MateThe body breaks down riluzole to get rid of it. Taking yerba mate can decrease how fast the body breaks down riluzole and increase the effects and side effects of riluzole.
- Carbamazepine (Tegretol) interacts with Yerba MateThe caffeine in yerba mate can decrease the effects of carbamazepine. Taking yerba mate with carbamazepine might decrease the effects of carbamazepine and increase the risk of seizures in some people.
- Ethosuximide (Zarontin) interacts with Yerba MateEthosuximide is a drug used to treat seizures. The caffeine in yerba mate can decrease the effects of ethosuximide. Taking yerba mate with ethosuximide might decrease the effects of ethosuximide and increase the risk of seizures in some people.
- Felbamate (Felbatol) interacts with Yerba MateFelbamate is a drug used to treat seizures. The caffeine in yerba mate might decrease the effects of felbamate. Taking yerba mate with felbamate might decrease the effects of felbamate and increase the risk of seizures in some people.
- Flutamide (Eulexin) interacts with Yerba MateThe body breaks down flutamide to get rid of it. The caffeine in yerba mate might decrease how quickly the body gets rid of flutamide. This could cause flutamide to stay in the body too long and increase the risk of side effects.
- Phenobarbital (Luminal) interacts with Yerba MatePhenobarbital is a drug used to treat seizures. Caffeine in yerba mate might decrease the effects of phenobarbital and increase the risk of seizures in some people.
- Phenytoin (Dilantin) interacts with Yerba MatePhenytoin is a drug used to treat seizures. Caffeine in yerba mate can decrease the effects of phenytoin. Taking yerba mate with phenytoin might decrease the effects of phenytoin and increase the risk of seizures in some people.
- Valproate interacts with Yerba MateValproate is a drug used to treat seizures. Caffeine in yerba mate might decrease the effects of valproate and increase the risk of seizures in some people.
- Water pills (Diuretic drugs) interacts with Yerba MateYerba mate contains caffeine. Caffeine, especially in large amounts, can reduce potassium levels in the body. "Water pills" can also decrease potassium levels in the body. Taking large amounts of caffeine along with "water pills" might decrease potassium levels too much.
- Pioglitazone (Actos) interacts with Yerba MateCaffeine in yerba mate might increase the amount of pioglitazone that the body absorbs. Taking yerba mate might increase the effects and adverse effects of pioglitazone.
- Midazolam (Versed) interacts with Yerba MateThe body breaks down midazolam to get rid of it. Yerba mate might decrease how quickly the body breaks down midazolam. Taking yerba mate along with midazolam might increase the effects and side effects of midazolam.
Minor Interaction
Be watchful with this combination
- Cimetidine (Tagamet) interacts with Yerba MateYerba mate contains caffeine. The body breaks down caffeine to get rid of it. Cimetidine can decrease how quickly the body breaks down caffeine. Taking cimetidine along with yerba mate might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.
- Terbinafine (Lamisil) interacts with Yerba MateYerba mate contains caffeine. Terbinafine can decrease how quickly the body gets rid of caffeine and increase the risk of caffeine side effects, such as jitteriness, increased heartbeat, and others.
- Theophylline interacts with Yerba MateYerba mate contains caffeine. Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Taking yerba mate along with theophylline might increase the effects and side effects of theophylline.
- Disulfiram (Antabuse) interacts with Yerba MateYerba mate contains caffeine. The body breaks down caffeine to get rid of it. Disulfiram can decrease how quickly the body gets rid of caffeine. Taking yerba mate along with disulfiram might increase the side effects of caffeine including jitteriness, irritability, and others.
- Estrogens interacts with Yerba MateYerba mate contains caffeine. The body breaks down caffeine to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Estrogens might increase the levels of caffeine and increase the risk of caffeine side effects, such as jitteriness, headache, and fast heartbeat.
- Medications for asthma (Beta-adrenergic agonists) interacts with Yerba MateYerba mate contains caffeine. Caffeine can stimulate the heart. Some medications for asthma can also stimulate the heart. Taking caffeine with some medications for asthma might cause too much stimulation and cause heart problems.
- Alcohol (Ethanol) interacts with Yerba MateThe body breaks down the caffeine in yerba mate to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking yerba mate along with alcohol might increase caffeine levels and the risk for caffeine side effects such as jitteriness, headache, and fast heartbeat.
- Antibiotics (Quinolone antibiotics) interacts with Yerba MateYerba mate contains caffeine. The body breaks down the caffeine in yerba mate to get rid of it. Some antibiotics can decrease how quickly the body breaks down caffeine. Taking these drugs along with caffeine might increase the risk of side effects including jitteriness, headache, and increased heart rate.
- Birth control pills (Contraceptive drugs) interacts with Yerba MateThe body breaks down the caffeine in yerba mate to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking yerba mate along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.
- Fluconazole (Diflucan) interacts with Yerba MateYerba mate contains caffeine. The body breaks down caffeine to get rid of it. Fluconazole might decrease how quickly the body gets rid of caffeine. This could increase levels of caffeine in the body and increase the risk of caffeine side effects.
- Fluvoxamine (Luvox) interacts with Yerba MateThe body breaks down the caffeine in yerba mate to get rid of it. Fluvoxamine can decrease how quickly the body breaks down caffeine. Taking yerba mate along with fluvoxamine might increase caffeine levels in the body and increase the risk of caffeine side effects.
- Mexiletine (Mexitil) interacts with Yerba MateYerba mate contains caffeine. Mexiletine can decrease how quickly the body breaks down caffeine. Taking mexiletine along with yerba mate might increase the risk of caffeine side effects.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with Yerba MateSome medications are changed and broken down by the liver. Yerba mate might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications that decrease break down of other medications by the liver (Cytochrome P450 CYP1A2 (CYP1A2) inhibitors) interacts with Yerba MateYerba mate is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down yerba mate. This could change the effects and side effects of yerba mate.
- Metformin (Glucophage) interacts with Yerba MateYerba mate contains caffeine. Metformin can decrease how quickly the body breaks down caffeine. Taking yerba mate with metformin might increase caffeine levels in the body and increase the effects and side effects of caffeine.
- Methoxsalen (Oxsoralen) interacts with Yerba MateYerba mate contains caffeine. Methoxsalen can decrease how quickly the body breaks down caffeine. Taking caffeine along with methoxsalen might increase caffeine levels in the body and increase the effects and side effects of caffeine.
- Sedative medications (Benzodiazepines) interacts with Yerba MateBenzodiazepines are drugs that cause sleepiness and drowsiness. The caffeine in yerba mate might increase the breakdown of benzodiazepines. This might reduce the effects of benzodiazepines. Do not use yerba mate if you are taking benzodiazepines.
- Tiagabine (Gabitril) interacts with Yerba MateYerba mate contains caffeine. Taking caffeine over a period of time along with tiagabine can increase the amount of tiagabine in the body. This might increase the effects and side effects of tiagabine.
- Ticlopidine (Ticlid) interacts with Yerba MateTiclopidine can decrease how quickly the body gets rid of caffeine. Taking yerba mate along with ticlopidine might increase the caffeine side effects, including jitteriness, hyperactivity, irritability, and others.
Dosing
Yerba mate is commonly consumed as a tea by steeping yerba mate leaf in boiling water. Speak with a healthcare provider to find out what dose might be best for a specific condition.
References
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr 1996;126:1181S-6S.
- Gotz V, Romankiewicz JA, Moss J, Murray HW. Prophylaxis against ampicillin-associated diarrhea with a lactobacillus preparation. Am J Hosp Pharm 1979;36:754-7.
- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503.
- Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S.
- Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40.
- Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8.
- Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50.
- Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
- Hsu CK, Leo P, Shastry D, et al. Anticholinergic poisoning associated with herbal tea. Arch Intern Med 1995;155:2245-8.
- Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9.
- Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
- For Dieter, Nearly the Ultimate Loss. The Washington Post. Available at: https://www.washingtonpost.com/archive/politics/2000/03/19/for-dieter-nearly-the-ultimate-loss/c0f07474-489d-4f44-bc17-1f1367c956ae/ (Accessed 19 March 2000).
- Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73.
- Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63.
- Pintos J, Franco EL, Oliveira BV, et al. Mate, coffee, and tea consumption and risk of cancers of the upper aerodigestive tract in southern Brazil. Epidemiology 1994;5:583-90.
- De Stefani E, Fierro L, Mendilaharsu M, et al. Meat intake, 'mate' drinking and renal cell cancer in Uruguay: a case-control study. Br J Cancer 1998;78:1239-43.
- De Stefani E, Correa P, Fierro L, et al. Black tobacco, mate, and bladder cancer. A case-control study from Uruguay. Cancer 1991;67:536-40.
- De Stefani E, Fierro L, Correa P, et al. Mate drinking and risk of lung cancer in males: a case-control study from Uruguay. Cancer Epidemiol Biomarkers Prev 1996;5:515-9.
- Wallach J. Interpretation of Diagnostic Tests. A synopsis of Laboratory Medicine. Fifth ed; Boston, MA: Little Brown, 1992.
- Vandeberghe K, Gillis N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452-7.
- Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80.
- Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700.
- The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: https://cerhr.niehs.nih.gov/common/caffeine.html.
- Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44.
- Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44.
- Stookey JD. The diuretic effects of alcohol and caffeine and total water intake misclassification. Eur J Epidemiol 1999;15:181-8.
- Wemple RD, Lamb DR, McKeever KH. Caffeine vs caffeine-free sports drinks: effects on urine production at rest and during prolonged exercise. Int J Sports Med 1997;18:40-6.
- Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40.
- DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
- Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9.
- Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32.
- FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: http://www.verity.fda.gov (Accessed 25 January 2000).
- Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24.
- Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr 1998;17:216-34.
- Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63.
- McGee J, Patrick RS, Wood CB, Blumgart LH. A case of veno-occlusive disease of the liver in Britain associated with herbal tea consumption. J Clin Pathol 1976;29:788-94.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9.
- Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61.
- American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89.
- Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9.
- Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8.
- Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13.
- Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3.
- Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4.
- Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5..
- Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403.
- Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80.
- Bara AI, Barley EA. Caffeine for asthma. Cochrane Database Syst Rev 2001;4:CD001112..
- McGowan JD, Altman RE, Kanto WP Jr. Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. South Med J 1988;81:1092-4..
- Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70.
- Dreher HM. The effect of caffeine reduction on sleep quality and well-being in persons with HIV. J Psychosom Res 2003;54:191-8..
- Grandjean AC, Reimers KJ, Bannick KE, Haven MC. The effect of caffeinated, non-caffeinated, caloric and non-caloric beverages on hydration. J Am Coll Nutr 2000;19:591-600..
- Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51..
- Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183.
- Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2.
- Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4.
- Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30.
- May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61.
- Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985;28:425-8.
- Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71.
- Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72.
- Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83.
- Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53.
- Stanek EJ, Melko GP, Charland SL. Xanthine interference with dipyridamole-thallium-201 myocardial imaging. Pharmacother 1995;29:425-7.
- Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55.
- Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50.
- Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6.
- Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole (201)Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7.
- Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: https://books.nap.edu/books/0309082587/html/index.html.
- Howell LL, Coffin VL, Spealman RD. Behavioral and physiological effects of xanthines in nonhuman primates. Psychopharmacology (Berl) 1997;129:1-14.
- Chou T. Wake up and smell the coffee. Caffeine, coffee, and the medical consequences. West J Med 1992;157:544-53.
- Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3.
- Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61.
- Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70.
- Durrant KL. Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 2002;42:625-37.
- Goldenberg D, Golz A, Joachims HZ. The beverage mate: a risk factor for cancer of the head and neck. Head Neck 2003;25:595-601.
- Sewram V, De Stefani E, Brennan P, Boffetta P. Mate consumption and the risk of squamous cell esophageal cancer in uruguay. Cancer Epidemiol Biomarkers Prev 2003;12:508-13.
- Esmelindro AA, Girardi Jdos S, Mossi A, et al. Influence of agronomic variables on the composition of mate tea leaves (Ilex paraguariensis) extracts obtained from CO2 extraction at 30 degrees C and 175 bar. J Agric Food Chem 2004;52:1990-5.
- Andersen T, Fogh J. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. J Hum Nutr Diet 2001;14:243-50.
- Saldana MD, Zetzl C, Mohamed RS, Brunner G. Extraction of methylxanthines from guarana seeds, mate leaves, and cocoa beans using supercritical carbon dioxide and ethanol. J Agric Food Chem 2002;50:4820-6.
- Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. Caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27:2047-8.
- Petrie HJ, Chown SE, Belfie LM, et al. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr 2004;80:22-8.
- Santos IS, Matijasevich A, Valle NC. Mate drinking during pregnancy and risk of preterm and small for gestational age birth. J Nutr 2005;135:1120-3.
- Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003..
- Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr 2004;79:40-6.
- Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8.
- Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15.
- Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29.
- Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA 2005;294:2330-5.
- Watson JM, Sherwin RS, Deary IJ, et al. Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci (Lond) 2003;104:447-54.
- Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 2004;94:13-8.
- Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41.
- Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85.
- Robinson LE, Savani S, Battram DS, et al. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J Nutr 2004;134:2528-33.
- Conforti AS, Gallo ME, Saraví FD. Yerba Mate (Ilex paraguariensis) consumption is associated with higher bone mineral density in postmenopausal women. Bone 2012;50:9-13.
- Kynast-Gales SA, Massey LK. Effect of caffeine on circadian excretion of urinary calcium and magnesium. J Am Coll Nutr. 1994;13:467-72.
- Shet, M. S., McPhaul, M., Fisher, C. W., Stallings, N. R., and Estabrook, R. W. Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos. 1997;25(11):1298-1303.
- Staib, A. H., Stille, W., Dietlein, G., Shah, P. M., Harder, S., Mieke, S., and Beer, C. Interaction between quinolones and caffeine. Drugs 1987;34 Suppl 1:170-174.
- Stille, W., Harder, S., Mieke, S., Beer, C., Shah, P. M., Frech, K., and Staib, A. H. Decrease of caffeine elimination in man during co-administration of 4-quinolones. J.Antimicrob.Chemother. 1987;20(5):729-734.
- Fuhr, U., Strobl, G., Manaut, F., Anders, E. M., Sorgel, F., Lopez-de-Brinas, E., Chu, D. T., Pernet, A. G., Mahr, G., Sanz, F., and . Quinolone antibacterial agents: relationship between structure and in vitro inhibition of the human cytochrome P450 isoform CYP1A2. Mol.Pharmacol. 1993;43(2):191-199.
- Kot, M. and Daniel, W. A. Effect of diethyldithiocarbamate (DDC) and ticlopidine on CYP1A2 activity and caffeine metabolism: an in vitro comparative study with human cDNA-expressed CYP1A2 and liver microsomes. Pharmacol Rep. 2009;61(6):1216-1220.
- Gasior, M., Borowicz, K., Buszewicz, G., Kleinrok, Z., and Czuczwar, S. J. Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. Epilepsia 1996;37(3):262-268.
- Jankiewicz, K., Chroscinska-Krawczyk, M., Blaszczyk, B., and Czuczwar, S. J. [Caffeine and antiepileptic drugs: experimental and clinical data]. Przegl.Lek. 2007;64(11):965-967.
- Luszczki, J. J., Zuchora, M., Sawicka, K. M., Kozinska, J., and Czuczwar, S. J. Acute exposure to caffeine decreases the anticonvulsant action of ethosuximide, but not that of clonazepam, phenobarbital and valproate against pentetrazole-induced seizures in mice. Pharmacol Rep. 2006;58(5):652-659.
- Chroscinska-Krawczyk, M., Jargiello-Baszak, M., Walek, M., Tylus, B., and Czuczwar, S. J. Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Pharmacol.Rep. 2011;63(1):12-18.
- Vaz, J., Kulkarni, C., David, J., and Joseph, T. Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. Indian J.Exp.Biol. 1998;36(1):112-114.
- Gasior, M., Swiader, M., Przybylko, M., Borowicz, K., Turski, W. A., Kleinrok, Z., and Czuczwar, S. J. Felbamate demonstrates low propensity for interaction with methylxanthines and Ca2+ channel modulators against experimental seizures in mice. Eur.J Pharmacol 7-10-1998;352(2-3):207-214.
- Mohiuddin, M., Azam, A. T., Amran, M. S., and Hossain, M. A. In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats. Pak.J Biol Sci 5-1-2009;12(9):734-737.
- Mays, D. C., Camisa, C., Cheney, P., Pacula, C. M., Nawoot, S., and Gerber, N. Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans. Clin.Pharmacol.Ther. 1987;42(6):621-626.
- Norager, C. B., Jensen, M. B., Weimann, A., and Madsen, M. R. Metabolic effects of caffeine ingestion and physical work in 75-year old citizens. A randomized, double-blind, placebo-controlled, cross-over study. Clin Endocrinol (Oxf) 2006;65(2):223-228.
- Wang, X. and Yeung, J. H. Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats. J Pharm Pharmacol 2010;62(8):1077-1083.
- Gorski, J. C., Huang, S. M., Pinto, A., Hamman, M. A., Hilligoss, J. K., Zaheer, N. A., Desai, M., Miller, M., and Hall, S. D. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004;75(1):89-100.
- Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353.
- Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 2010;33(2):243-246.
- Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682.
- Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406.
- Azcona O, Barbanoi MJ, Torrent J, Jane F. Evaluation of the central effects of alcohol and caffeine interaction. Br J Clin Pharmacol 1995;40:393-400.
- Broughton LJ, Rogers HJ. Decreased systemic clearance of caffeine due to cimetidine. Br J Clin Pharmacol 1981;12:155-9.
- File SE, Bond AJ, Lister RG. Interaction between effects of caffeine and lorazepam in performance tests and self-ratings. J Clin Psychopharmacol 1982;2:102-6.
- Mattila MJ, Palva E, Savolainen K. Caffeine antagonizes diazepam effects in man. Med Biol 1982;60:121-3.
- Mattila MJ, Nuotto E. Caffeine and theophylline counteract diazepam effects in man. Med Biol 1983;61:337-43.
- Mattila ME, Mattila MJ, Nuotto E. Caffeine moderately antagonizes the effects of triazolam and zopiclone on the psychomotor performance of healthy subjects. Pharmacol Toxicol 1992;70:286-9.
- Mattila MJ, Vainio P, Nurminen ML, et al. Midazolam 12 mg is moderately counteracted by 250 mg caffeine in man. Int J Clin Pharmacol Ther 2000;38:581-7.
- Zelenitsky SA, Norman A, Nix DE. The effects of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. J Infect Dis Pharmacother 1995;1:1-11.
- Joeres R, Richter E. Mexiletine and caffeine elimination. N Engl J Med 1987;317:117.
- Jia H, Xu A, Yuan J, et al. Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus. Zhongguo Zhong Yao Za Zhi 2009;34:2079-82.
- ROTH, J. L. Clinical evaluation of the caffeine gastric analysis in duodenal ulcer patients. Gastroenterology 1951;19(2):199-215.
- Sung, B. H., Whitsett, T. L., Lovallo, W. R., al'Absi, M., Pincomb, G. A., and Wilson, M. F. Prolonged increase in blood pressure by a single oral dose of caffeine in mildly hypertensive men. Am.J Hypertens. 1994;7(8):755-758.
- Smits, P., Temme, L., and Thien, T. The cardiovascular interaction between caffeine and nicotine in humans. Clin Pharmacol Ther 1993;54(2):194-204.
- MacKenzie, T., Comi, R., Sluss, P., Keisari, R., Manwar, S., Kim, J., Larson, R., and Baron, J. A. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism 2007;56(12):1694-1698.
- Mort, J. R. and Kruse, H. R. Timing of blood pressure measurement related to caffeine consumption. Ann Pharmacother. 2008;42(1):105-110.
- Lopez-Garcia, E., Rodriguez-Artalejo, F., Rexrode, K. M., Logroscino, G., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of stroke in women. Circulation 3-3-2009;119(8):1116-1123.
- Zhang, W., Lopez-Garcia, E., Li, T. Y., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of cardiovascular diseases and all-cause mortality among men with type 2 diabetes. Diabetes Care 2009;32(6):1043-1045.
- Moisey, L. L., Robinson, L. E., and Graham, T. E. Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males. Br.J Nutr. 2010;103(6):833-841.
- Simmonds, M. J., Minahan, C. L., and Sabapathy, S. Caffeine improves supramaximal cycling but not the rate of anaerobic energy release. Eur.J Appl Physiol 2010;109(2):287-295.
- Buscemi, S., Verga, S., Batsis, J. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., and Cerasola, G. Acute effects of coffee on endothelial function in healthy subjects. Eur.J Clin Nutr. 2010;64(5):483-489.
- Rigato, I., Blarasin, L., and Kette, F. Severe hypokalemia in 2 young bicycle riders due to massive caffeine intake. Clin J Sport Med. 2010;20(2):128-130.
- Casiglia, E., Bongiovi, S., Paleari, C. D., Petucco, S., Boni, M., Colangeli, G., Penzo, M., and Pessina, A. C. Haemodynamic effects of coffee and caffeine in normal volunteers: a placebo-controlled clinical study. J.Intern.Med. 1991;229(6):501-504.
- Farag, N. H., Whitsett, T. L., McKey, B. S., Wilson, M. F., Vincent, A. S., Everson-Rose, S. A., and Lovallo, W. R. Caffeine and blood pressure response: sex, age, and hormonal status. J Womens Health (Larchmt.) 2010;19(6):1171-1176.
- Ernest, D., Chia, M., and Corallo, C. E. Profound hypokalaemia due to Nurofen Plus and Red Bull misuse. Crit Care Resusc. 2010;12(2):109-110.
- Conen, D., Chiuve, S. E., Everett, B. M., Zhang, S. M., Buring, J. E., and Albert, C. M. Caffeine consumption and incident atrial fibrillation in women. Am J Clin Nutr 2010;92(3):509-514.
- Bracesco, N., Sanchez, A. G., Contreras, V., Menini, T., and Gugliucci, A. Recent advances on Ilex paraguariensis research: Minireview. J Ethnopharmacol. 6-26-2010;
- Reis, J. P., Loria, C. M., Steffen, L. M., Zhou, X., van, Horn L., Siscovick, D. S., Jacobs, D. R., Jr., and Carr, J. J. Coffee, decaffeinated coffee, caffeine, and tea consumption in young adulthood and atherosclerosis later in life: the CARDIA study. Arterioscler.Thromb.Vasc.Biol 2010;30(10):2059-2066.
- Clausen, T. Hormonal and pharmacological modification of plasma potassium homeostasis. Fundam.Clin Pharmacol 2010;24(5):595-605.
- Gronroos, N. N. and Alonso, A. Diet and risk of atrial fibrillation - epidemiologic and clinical evidence -. Circ.J 2010;74(10):2029-2038.
- Orozco-Gregorio, H., Mota-Rojas, D., Bonilla-Jaime, H., Trujillo-Ortega, M. E., Becerril-Herrera, M., Hernandez-Gonzalez, R., and Villanueva-Garcia, D. Effects of administration of caffeine on metabolic variables in neonatal pigs with peripartum asphyxia. Am.J Vet.Res. 2010;71(10):1214-1219.
- Smits, P., Lenders, J. W., and Thien, T. Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Clin.Pharmacol.Ther. 1990;48(4):410-418.
- Birkett, N. J. and Logan, A. G. Caffeine-containing beverages and the prevalence of hypertension. J Hypertens.Suppl 1988;6(4):S620-S622.
- Jeppesen, U., Loft, S., Poulsen, H. E., and Brsen, K. A fluvoxamine-caffeine interaction study. Pharmacogenetics 1996;6(3):213-222.
- Quinlan, P., Lane, J., and Aspinall, L. Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type. Psychopharmacology (Berl) 1997;134(2):164-173.
- Fotherby, M. D., Ghandi, C., Haigh, R. A., Macdonald, T. A., and Potter, J. F. Sustained caffeine use has no pressor effect in the elderly. Cardiology in the Elderly 1994;2(6):499-503.
- Dickel, M. L., Rates, S. M., and Ritter, M. R. Plants popularly used for loosing weight purposes in Porto Alegre, South Brazil. J Ethnopharmacol 1-3-2007;109(1):60-71.
- Pittler, M. H. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. Am.J.Clin Nutr. 2004;79(4):529-536.
- Pittler, M. H., Schmidt, K., and Ernst, E. Adverse events of herbal food supplements for body weight reduction: systematic review. Obes.Rev. 2005;6(2):93-111.
- Martinet, A., Hostettmann, K., and Schutz, Y. Thermogenic effects of commercially available plant preparations aimed at treating human obesity. Phytomedicine. 1999;6(4):231-238.
- Gorzalczany, S., Filip, R., Alonso, M. R., Mino, J., Ferraro, G. E., and Acevedo, C. Choleretic effect and intestinal propulsion of 'mate' (Ilex paraguariensis) and its substitutes or adulterants. J Ethnopharmacol. 2001;75(2-3):291-294.
- Gugliucci, A. and Menini, T. The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III. Life Sci. 12-6-2002;72(3):279-292.
- Bates, M. N., Rey, O. A., Biggs, M. L., Hopenhayn, C., Moore, L. E., Kalman, D., Steinmaus, C., and Smith, A. H. Case-control study of bladder cancer and exposure to arsenic in Argentina. Am J Epidemiol. 2-15-2004;159(4):381-389.
- Lunceford, N. and Gugliucci, A. Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea. Fitoterapia 2005;76(5):419-427.
- Paganini Stein, F. L., Schmidt, B., Furlong, E. B., Souza-Soares, L. A., Soares, M. C., Vaz, M. R., and Muccillo Baisch, A. L. Vascular responses to extractable fractions of Ilex paraguariensis in rats fed standard and high-cholesterol diets. Biol.Res Nurs. 2005;7(2):146-156.
- Mosimann, A. L., Wilhelm-Filho, D., and da Silva, E. L. Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits. Biofactors 2006;26(1):59-70.
- Bates, M. N., Hopenhayn, C., Rey, O. A., and Moore, L. E. Bladder cancer and mate consumption in Argentina: a case-control study. Cancer Lett. 2-8-2007;246(1-2):268-273.
- Martin, I., Lopez-Vilchez, M. A., Mur, A., Garcia-Algar, O., Rossi, S., Marchei, E., and Pichini, S. Neonatal withdrawal syndrome after chronic maternal drinking of mate. Ther Drug Monit. 2007;29(1):127-129.
- Milioli, E. M., Cologni, P., Santos, C. C., Marcos, T. D., Yunes, V. M., Fernandes, M. S., Schoenfelder, T., and Costa-Campos, L. Effect of acute administration of hydroalcohol extract of Ilex paraguariensis St Hilaire (Aquifoliaceae) in animal models of Parkinson's disease. Phytother.Res 2007;21(8):771-776.
- Menini, T., Heck, C., Schulze, J., de, Mejia E., and Gugliucci, A. Protective action of Ilex paraguariensis extract against free radical inactivation of paraoxonase-1 in high-density lipoprotein. Planta Med. 2007;73(11):1141-1147.
- Pang, J., Choi, Y., and Park, T. Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue. Arch.Biochem.Biophys. 8-15-2008;476(2):178-185.
- Oliveira, D. M., Freitas, H. S., Souza, M. F., Arcari, D. P., Ribeiro, M. L., Carvalho, P. O., and Bastos, D. H. Yerba Mate (Ilex paraguariensis) aqueous extract decreases intestinal SGLT1 gene expression but does not affect other biochemical parameters in alloxan-diabetic Wistar rats. J Agric.Food Chem. 11-26-2008;56(22):10527-10532.
- Matsumoto, R. L., Bastos, D. H., Mendonca, S., Nunes, V. S., Bartchewsky, W., Ribeiro, M. L., and de Oliveira, Carvalho P. Effects of mate tea (Ilex paraguariensis) ingestion on mRNA expression of antioxidant enzymes, lipid peroxidation, and total antioxidant status in healthy young women. J Agric.Food Chem. 3-11-2009;57(5):1775-1780.
- Gugliucci, A. and Bastos, D. H. Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein from inactivation caused by physiological concentrations of hypochlorite. Fitoterapia 2009;80(2):138-142.
- Sugimoto, S., Nakamura, S., Yamamoto, S., Yamashita, C., Oda, Y., Matsuda, H., and Yoshikawa, M. Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of ilex paraguariensis. Chem.Pharm.Bull.(Tokyo) 2009;57(3):257-261.
- Gugliucci, A., Bastos, D. H., Schulze, J., and Souza, M. F. Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins. Fitoterapia 2009;80(6):339-344.
- Arcari, D. P., Bartchewsky, W., dos Santos, T. W., Oliveira, K. A., Funck, A., Pedrazzoli, J., de Souza, M. F., Saad, M. J., Bastos, D. H., Gambero, A., Carvalho, Pde O., and Ribeiro, M. L. Antiobesity effects of yerba mate extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity.(Silver.Spring) 2009;17(12):2127-2133.
- Martins, F., Noso, T. M., Porto, V. B., Curiel, A., Gambero, A., Bastos, D. H., Ribeiro, M. L., and Carvalho, Pde O. Mate tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice. Obesity.(Silver.Spring) 2010;18(1):42-47.
- de Morais, E. C., Stefanuto, A., Klein, G. A., Boaventura, B. C., de, Andrade F., Wazlawik, E., Di Pietro, P. F., Maraschin, M., and da Silva, E. L. Consumption of yerba mate ( Ilex paraguariensis ) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy. J Agric.Food Chem. 9-23-2009;57(18):8316-8324.
- Ranilla, L. G., Kwon, Y. I., Apostolidis, E., and Shetty, K. Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresour.Technol. 2010;101(12):4676-4689.
- Hussein, G. M., Matsuda, H., Nakamura, S., Akiyama, T., Tamura, K., and Yoshikawa, M. Protective and ameliorative effects of mate (Ilex paraguariensis) on metabolic syndrome in TSOD mice. Phytomedicine. 12-15-2011;19(1):88-97.
- Klein, G. A., Stefanuto, A., Boaventura, B. C., de Morais, E. C., Cavalcante, Lda S., de, Andrade F., Wazlawik, E., Di Pietro, P. F., Maraschin, M., and da Silva, E. L. Mate tea (Ilex paraguariensis) improves glycemic and lipid profiles of type 2 diabetes and pre-diabetes individuals: a pilot study. J Am Coll.Nutr. 2011;30(5):320-332.
- Matsumoto, R. L., Mendonca, S., de Oliveira, D. M., Souza, M. F., and Bastos, D. H. Effects of mate tea intake on ex vivo LDL peroxidation induced by three different pathways. Nutrients. 2009;1(1):18-29.
- De, Stefani E., Correa, P., Oreggia, F., Deneo-Pellegrini, H., Fernandez, G., Zavala, D., Carzoglio, J., Leiva, J., Fontham, E., and Rivero, S. Black tobacco, wine and mate in oropharyngeal cancer. A case-control study from Uruguay. Rev.Epidemiol.Sante Publique 1988;36(6):389-394.
- Vassallo, A., Correa, P., De, Stefani E., Cendan, M., Zavala, D., Chen, V., Carzoglio, J., and Deneo-Pellegrini, H. Esophageal cancer in Uruguay: a case-control study. J Natl.Cancer Inst. 1985;75(6):1005-1009.
- Gugliucci, A. and Stahl, A. J. Low density lipoprotein oxidation is inhibited by extracts of Ilex paraguariensis. Biochem.Mol.Biol.Int. 1995;35(1):47-56.
- Gugliucci, A. Antioxidant effects of Ilex paraguariensis: induction of decreased oxidability of human LDL in vivo. Biochem.Biophys.Res.Commun. 7-16-1996;224(2):338-344.
- Muccillo Baisch, A. L., Johnston, K. B., and Paganini Stein, F. L. Endothelium-dependent vasorelaxing activity of aqueous extracts of Ilex paraguariensis on mesenteric arterial bed of rats. J Ethnopharmacol. 1998;60(2):133-139.
- Meyer, K. and Ball, P. Psychological and Cardiovascular Effects of Guarana and Yerba Mate: A Comparison with Coffee. Revista Interamericana de Psicologia 2004;38(1):87-94.
- Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart. 2013;99(19):1383-9. doi: 10.1136/heartjnl-2013-303950. Review.
- Cheng M, Hu Z, Lu X, Huang J, Gu D. Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies. Can J Cardiol. 2014 Apr;30(4):448-54. doi: 10.1016/j.cjca.2013.12.026. Epub 2014 2. Review.
- Jiwani AZ, Rhee DJ, Brauner SC, Gardiner MF, Chen TC, Shen LQ, Chen SH, Grosskreutz CL, Chang KK, Kloek CE, Greenstein SH, Borboli-Gerogiannis S, Pasquale DL, Chaudhry S, Loomis S, Wiggs JL, Pasquale LR, Turalba AV. Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye (Lond). 2012;26(8):1122-30. doi: 10.1038/eye.2012.113. Epub 2012 Jun 8.
- Tejani FH, Thompson RC, Kristy R, Bukofzer S. Effect of caffeine on SPECT myocardial perfusion imaging during regadenoson pharmacologic stress: a prospective, randomized, multicenter study. Int J Cardiovasc Imaging. 2014 Jun;30(5):979-89. doi: 10.1007/s10554-014-0419-7. Epub 2014 17.
- van der Hoeven N, Visser I, Schene A, van den Born BJ. Severe hypertension related to caffeinated coffee and tranylcypromine: a case report. Ann Intern Med. 2014 May 6;160(9):657-8. doi: 10.7326/L14-5009-8. No abstract available.
- Dixit S, Stein PK, Dewland TA, Dukes JW, Vittinghoff E, Heckbert SR, Marcus GM. Consumption of Caffeinated Products and Cardiac Ectopy. J Am Heart Assoc. 2016 26;5(1). pii: e002503. doi: 10.1161/JAHA.115.002503.
- Gambero A and Ribeiro ML. The positive effects of yerba mate (Ilex paraguariensis) in obesity. Nutrients. 2015;7(2):730-50.
- Stefani ED, Moore M, Aune D, Deneo-Pellegrini H, Ronco AL, Boffetta P, et al. Maté consumption and risk of cancer: a multi-site case-control study in Uruguay. Asian Pac J Cancer Prev. 2011;12(4):1089-93.
- Yu S, Yue SW, Liu Z, Zhang T, Xiang N, Fu H. Yerba mate (Ilex paraguariensis) improves microcirculation of volunteers with high blood viscosity: a randomized, double-blind, placebo-controlled trial. Exp Gerontol. 2015;62:14-22.
- Kim SY, Oh MR, Kim MG, Chae HJ, Chae SW. Anti-obesity effects of yerba mate (Ilex Paraguariensis): a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med. 2015;15:338.
- International Agency for Research on Cancer (IARC). IARC monographs evaluate drinking coffee, mate, and very hot beverages. https://www.iarc.fr/en/media-centre/pr/2016/pdfs/pr244_E.pdf. Accessed November 1, 2017.
- Zuchinali P, Riberio PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. Effect of caffeine on ventricular arrhythmia: a systematic review and meta-analysis of experimental and clinical studies. Europace 2016 Feb;18(2):257-66.
- da veiga DTA, Bringhenti R, Bolignon AA, et al. The yerba mate intake has a neutral effect on bone: a case-control study in postmenopausal women. Phytother Res. 2018 Jan;32(1):58-64.
- Alkhatib A, Atcheson R. Yerba Mate (Ilex paraguariensis) metabolic, satiety, and mood state effects at rest and during prolonged exercise. Nutrients. 2017 Aug 15;9(8). Pii:E882.
- Jung J-H, Hur Y-I. The effect of mate extract on body weight and fat reduction in obese women: a randomized placebo-controlled clinical trial. Korean J OBes. 2016;25:197-206.
- Areta JL, Austarheim I, Wangensteen H, Capelli C. Metabolic and performance effects of yerba mate on well-trained cyclists. Med Sci Sports Exerc. 2017 Nov 7.
- Souza SJ, Petrilli AA, Teixeira AM, et al. Effect of chocolate and mate tea on the lipid profile of individuals with HIV/AIDS on antiretroviral therapy: a clinical trial. Nutrition. 2017 Nov-Dec;43-44:61-68.
- Lagier D, Nee L, Guieu R, et al. Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass: a randomized controlled clinical trial. Eur J Anaesthesiol. 2018 Apr 26. [Epub ahead of print]
- Voskoboinik A, Kalman JM, Kistler PM. Caffeine and arrhythmias: time to grind the data. JACC: Clin Electrophysiol. 2018;4(4):425-32.
- Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 2017;109:585-648.
- Chaves G, Britez N, Oviedo G, et al. Heavy drinkers of Ilex paraguariensis beverages show lower lipid profiles but higher body weight. Phytother Res. 2018;32(6):1030-1038.
- Gómez-Juaristi M, Martínez-López S, Sarria B, Bravo L, Mateos R. Absorption and metabolism of yerba mate phenolic compounds in humans. Food Chem. 2018;240:1028-1038.
- Rao SS. Current and emerging treatment options for fecal incontinence. J Clin Gastroenterol. 2014;48(9):752-64.
- Cozma-Petrut A, Loghin F, Miere D, Dumitrascu DL.Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients! World J Gastroenterol. 2017;23(21):3771-3783.
- Gebara KS, Gasparotto Junior A, Palozi RAC, et al. A Randomized Crossover Intervention Study on the Effect a Standardized Maté Extract (Ilex paraguariensis A. St.-Hil.) in Men Predisposed to Cardiovascular Risk. Nutrients 2020;13(1):14.
- Feltrin C, Farias IV, Sandjo LP, Reginatto FH, Simões CMO. Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes. Chem Res Toxicol 2020;33(9):2408-2419.
- Medeiros MS, Schumacher-Schuh AF, Altmann V, Rieder CRM. A Case-Control Study of the Effects of Chimarrão (Ilex paraguariensis) and Coffee on Parkinson's Disease. Front Neurol 2021;12:619535.
- Pagliosa CM, Vieira FGK, Dias BV, Brognoli Franco VK, Ramos HP, da Silva EL. Ilex paraguariensis (A. St.-Hil.) leaf infusion decreases iron absorption in patients with hereditary hemochromatosis: a randomized controlled crossover study. Food Funct 2021;12(16):7321-7328.
- Zheng KH, Zhu K, Wactawski-Wende J, et al. Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. Int J Cancer 2021;149(12):2032-2044.
- Wang S, Li X, Yang Y, et al. Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis. Public Health Nutr 2021;24(18):6377-6389.
- Alshabi AM, Alkahtani SA, Shaikh IA, Habeeb MS. Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics. Saudi Med J 2021;42(2):151-160.
- Gleason JL, Sundaram R, Mitro SD, et al. Association of maternal caffeine consumption during pregnancy with child growth. JAMA Netw Open. 2022;5(10):e2239609.
- Masson W, Barbagelata L, Lobo M, Nogueira JP, Corral P, Lavalle-Cobo A. Effect of Yerba Mate (Ilex paraguariensis) on Lipid Levels: A Systematic Review and Meta-Analysis. Plant Foods Hum Nutr 2022;77(3):353-366.
- Lobo PCB, da Silva DD, Pimentel GD. Acute Supplementation of Yerba Mate Extract Did Not Change Muscle Strength in Physically Active Men Following the Strength Muscle Test: A Pilot Clinical Trial. Nutrients 2022;14(13):2619.