Sodium Bicarbonate
OTHER NAME(S): Baking Soda, Bicarbonate of Soda, Bread Soda, Cooking Soda, Sodium Hydrogen Carbonate, Bicarbonato de Sodio, Bicarbonate de sodium
Overview
Sodium bicarbonate is a salt that breaks down to form sodium and bicarbonate in water. This makes a solution alkaline, meaning it's able to neutralize acid.
Sodium bicarbonate's ability to neutralize acid helps treat conditions related to high acidity in bodily fluids, such as indigestion, which is caused by too much acid in the stomach.
People commonly use sodium bicarbonate for indigestion. It is also used for stomach ulcers, athletic performance, kidney damage, dental plaque, tooth discoloration, and many other conditions, but there is no good scientific evidence to support many of these uses.
Uses
Likely Effective for
- Indigestion (dyspepsia). Over-the-counter antacid products containing sodium bicarbonate are considered effective when taken by mouth for indigestion. They are FDA-approved for this use.
Possibly Effective for
- Athletic performance. Taking sodium bicarbonate by mouth seems to improve athletic performance by a small amount in most people.
- Toxicity from drugs that affect the function of sodium channels (sodium channel blockade). Giving sodium bicarbonate by IV seems to help to reduce side effects from drugs that cause sodium channel blockade. IV products can only be given by a healthcare provider.
- A mild form of gum disease (gingivitis). Brushing the teeth with sodium bicarbonate seems to be help with gingivitis.
Possibly Ineffective for
- Sudden loss of heart function (cardiac arrest). Giving sodium bicarbonate by IV does not increase survival in children or adults who experienced cardiac arrest outside of the hospital. It might even worsen recovery. IV products can only be given by a healthcare provider.
- Tissue damage caused when there is limited blood flow and then blood flow is restored (ischemia-reperfusion injury). Giving sodium bicarbonate by IV does not prevent kidney problems in people who have had heart surgery. IV products can only be given by a healthcare provider.
There is interest in using sodium bicarbonate for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When taken by mouth: Sodium bicarbonate is likely safe when used appropriately, short-term. Over-the-counter antacid products containing sodium bicarbonate are considered safe and effective by the US FDA. Taking sodium bicarbonate in very high doses is possibly unsafe. It is also possibly unsafe to take sodium bicarbonate that it is not fully dissolved into a solution. Stomach rupture and serious changes in electrolyte levels have occurred.
When applied to the skin: There isn't enough reliable information to know if sodium bicarbonate is safe to use or what the side effects might be.
Precautions
When taken by mouth: Sodium bicarbonate is likely safe when used appropriately, short-term. Over-the-counter antacid products containing sodium bicarbonate are considered safe and effective by the US FDA. Taking sodium bicarbonate in very high doses is possibly unsafe. It is also possibly unsafe to take sodium bicarbonate that it is not fully dissolved into a solution. Stomach rupture and serious changes in electrolyte levels have occurred.
When applied to the skin: There isn't enough reliable information to know if sodium bicarbonate is safe to use or what the side effects might be.
Pregnancy: Sodium bicarbonate is possibly unsafe when taken by mouth during pregnancy. There is some concern that it might increase the risk of water retention or pH imbalances in the tissues.
Breast-feeding: There isn't enough reliable information to know if sodium bicarbonate is safe to use while breast feeding. Stay on the safe side and avoid use.
Children: There isn't enough reliable information to know if sodium bicarbonate is safe to use by mouth in children. Stay on the safe side and avoid use. Sodium bicarbonate is possibly unsafe when applied to the skin. There have been reports of high sodium blood levels in children following use.
Burns: Applying sodium bicarbonate to burns might increase burn thickness in the skin.
Sudden loss of heart function (cardiac arrest): Sodium bicarbonate doesn't seem to help in people who have had cardiac arrest. It might reduce survival or slow down recovery.
Diabetic ketoacidosis (DKA): Sodium bicarbonate increases blood acids called ketones, which are associated with DKA. Sodium bicarbonate should not be used in people with this condition.
Swelling (edema): Because sodium bicarbonate contains sodium, it can increase the risk of swelling caused by excess fluids in the body. People with heart failure, liver disease, or other conditions associated with fluid build-up should use sodium bicarbonate with caution.
High calcium levels in the blood: People with high calcium levels in the blood can have trouble getting rid of bicarbonate. Taking sodium bicarbonate might increase the risk of complications such as milk-alkali syndrome.
High sodium levels in the blood: Sodium bicarbonate might increase sodium levels in the blood. People who already have high levels of sodium in the blood should avoid sodium bicarbonate.
High blood pressure: Sodium bicarbonate might increase blood pressure. People who already have high blood pressure should avoid sodium bicarbonate.
Low potassium levels in the blood: Sodium bicarbonate might lower potassium blood levels. People who already have low levels of potassium should avoid sodium bicarbonate.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications that contain sodium interacts with Sodium BicarbonateTaking sodium bicarbonate with medications that contain sodium might result in sodium intakes that are possibly unsafe. In some people, this might cause sodium levels in the blood to become too high.
- Antibiotics (Aminoglycoside antibiotics) interacts with Sodium BicarbonateTaking sodium bicarbonate can decrease potassium levels in the body. Aminoglycosides can also decrease potassium levels. Taking sodium bicarbonate along with aminoglycosides might decrease potassium too much.
- Amphotericin-B (Abelcet, others) interacts with Sodium BicarbonateTaking sodium bicarbonate can decrease potassium levels in the body. Amphotericin B can also decrease potassium levels. Taking sodium bicarbonate along with amphotericin B might decrease potassium too much.
- Medications for asthma (Beta-adrenergic agonists) interacts with Sodium BicarbonateSodium bicarbonate can decrease potassium levels in the body. Beta-adrenergic agonists can also decrease potassium levels. Taking sodium bicarbonate along with beta-adrenergic agonists might decrease potassium too much.
- Cisplatin (Platinol-AQ) interacts with Sodium BicarbonateSodium bicarbonate can decrease potassium levels in the body. Cisplatin can also decrease potassium levels. Taking sodium bicarbonate along with cisplatin might decrease potassium too much.
- Medications for inflammation (Corticosteroids) interacts with Sodium BicarbonateTaking sodium bicarbonate can decrease potassium levels in the body. Some corticosteroids can also decrease potassium levels. Taking sodium bicarbonate along with some corticosteroids might decrease potassium too much.
- Methylxanthines interacts with Sodium BicarbonateTaking sodium bicarbonate can decrease potassium levels in the body. Methylxanthines can also decrease potassium levels. Taking sodium bicarbonate along with methylxanthines might decrease potassium too much.
- Stimulant Laxatives interacts with Sodium BicarbonateSodium bicarbonate can decrease potassium levels in the body. Stimulant laxatives can also decrease potassium levels. Taking sodium bicarbonate along with stimulant laxatives might decrease potassium too much.
- Water pills (Thiazide diuretics) interacts with Sodium BicarbonateSodium bicarbonate can decrease potassium levels in the body. "Water pills" can also decrease potassium levels. Taking sodium bicarbonate along with "water pills" might decrease potassium levels too much.
- Cefpodoxime Proxetil (Vantin) interacts with Sodium BicarbonateCefpodoxime proxetil, an antibiotic, must be changed to its active form in the body. Sodium bicarbonate slows down this change to the active form in the body. This might reduce how well this drug works.
- Chlorpropamide (Diabinese) interacts with Sodium BicarbonateTaking sodium bicarbonate with chlorpropamide increases how quickly the body gets rid of chlorpropamide. This might reduce how well chlorpropamide works.
- Water pills (Loop diuretics) interacts with Sodium BicarbonateSodium bicarbonate can decrease potassium levels in the body. "Water pills" can also decrease potassium levels. Taking sodium bicarbonate along with "water pills" might decrease potassium too much.
- Pseudoephedrine (Sudafed) interacts with Sodium BicarbonateSodium bicarbonate might slow down how quickly the body gets rid of pseudoephedrine. This might increase pseudoephedrine levels in the body and increase the risk of side effects.
Minor Interaction
Be watchful with this combination
- Aspirin interacts with Sodium BicarbonateSodium bicarbonate might increase how quickly the body breaks down aspirin. This might reduce the effects of aspirin. Aspirin and sodium bicarbonate should be taken separately.
Dosing
Sodium bicarbonate is found in FDA-approved OTC antacid products. It is also found in other supplements. Sodium bicarbonate has most often been used by adults in doses of 100-400 mg/kg by mouth daily for 3-7 days. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
Sodium bicarbonate is also found in toothpastes, mouth rinses, and ear drops. Sodium bicarbonate, or baking soda, is also used in foods.
References
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Ritsema GH, Ellers G. Potassium supplements prevent serious hypokalemia in colon cleansing. Clin Radiol 1994;49;874-6.
- Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Robertson JI. Diuretics, potassium depletion and risk of arrhythmias. Eur Heart J 1984;5(Suppl A):25-8.
- Lipworth BJ, McDevitt DG. Beta-adrenoceptor responses to inhaled salbutamol in normal subjects. Eur J Clin Pharmacol 1989;36:239-45..
- Deenstra M, Haalboom JRE, Struyvenberg A. Decrease of plasma potassium due to inhalation of beta-2-agonists: absence of an additional effect of intravenous theophylline. Eur J Clin Invest 1988;18:162-5..
- Braden GL, von Oeyen PT, Germain MJ, et al. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Kidney Int 1997;51:1867-75..
- Shrestha M, Bidadi K, Gourlay S, Hayes J. Continuous vs intermittent albuterol, as high and low doses, in the treatment of severe acute asthma in adults. Chest 1996;110:42-7..
- Rahman ARA, McDevitt DG, Struthers AD, Lipworth BJ. The effects of enalapril and spironolactone on terbutaline-induced hypokalemia. Chest 1992;102:91-5..
- Clifton GD, Hunt BA, Patel RC, Burki NK. Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses. Am Rev Respir Dis 1990;141:575-9..
- Haalboom JRE, Deenstra M, Struyvenberg A. Effect of fenoterol on plasma potassium and cardiac ectopic activity (letter). Lancet 1989;2:45.
- Raimondi GA, Rodriguez-Moncalvo JJ. Effects of beta-adrenergic agents on hypokalemia (letter). Chest 1987;91:288-9.
- Gelmont DM, Balmes JR, Yee A. Hypokalemia induced by inhaled bronchodilators. Chest 1988;94:763-6..
- Kung M, White JR, Burki NK. The effect of subcutaneously administered terbutaline on serum potassium in asymptomatic adult asthmatics. Am Rev Respir Dis 1984;129:329-32..
- Rohr AS, Spector SL, Rachelefsky GS, et al. Efficacy of parenteral albuterol in the treatment of asthma: Comparison of its metabolic side effects with subcutaneous epinephrine. Chest 1986;89:348-51..
- Isaac G, Holland OB. Drug-induced hypokalamia: A cause for concern. Drugs & Aging 1992;2:35-41.
- Crane J, Burgess CD, Graham AN, Maling TJB. Hypokalemic and electrocardiographic effects of aminophylline and salbutamol in obstructive airways disease. NZ Med J 1987;100:309-11.
- Zantvoort FA, Derkx FHM, Boomsma F, et al. Theophylline and serum electrolytes (letter). Ann Int Med 1986;104:134-5.
- Braat MCP, Jonkers RE, Bel EH, Van Boxtel CJ. Quantification of theophylline-induced eosinopenia and hypokalamia in healthy volunteers. Clin Pharmacokinet 1992;22:231-7..
- Flack JM, Ryder KW, Strickland D, Whang R. Metabolic correlates of theophylline therapy: a concentration-related phenomenon. Ann Pharmacother 1994;28:175-9..
- Smith SR, Kendall MJ. Metabolic responses to beta-2 stimulants. J R Coll Phys Lond 1984;18:190-4.
- Food and Drug Administration. A Catalog of FDA Approved Drug Products. Available at: https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ (Accessed 28 June 2005).
- Mohammadianpanah M, Omidvari S, Mosalaei A, Ahmadloo N. Cisplatin-induced hypokalemic paralysis. Clin Ther 2004;26:1320-3.
- Panichpisal K, Angulo-Pernett F, Selhi S, Nugent KM. Gitelman-like syndrome after cisplatin therapy: a case report and literature review. BMC Nephrol 2006;7:10.
- Bjornson DC, Stephenson SR. Cisplatin-induced massive renal tubular failure with wastage of serum electrolytes. Clin Pharm 1983;2;80-3.
- Lokesh, L., Kumar, P., Murki, S., and Narang, A. A randomized controlled trial of sodium bicarbonate in neonatal resuscitation-effect on immediate outcome. Resuscitation 2004;60(2):219-223.
- Stellingwerff, T., Boit, M. K., and Res, P. T. Nutritional strategies to optimize training and racing in middle-distance athletes. J Sports Sci 2007;25 Suppl 1:S17-S28.
- Clegg, A. J., Loveman, E., Gospodarevskaya, E., Harris, P., Bird, A., Bryant, J., Scott, D. A., Davidson, P., Little, P., and Coppin, R. The safety and effectiveness of different methods of earwax removal: a systematic review and economic evaluation. Health Technol Assess 2010;14(28):1-192.
- Ho, K. M. and Morgan, D. J. Use of isotonic sodium bicarbonate to prevent radiocontrast nephropathy in patients with mild pre-existing renal impairment: a meta-analysis. Anaesth Intensive Care 2008;36(5):646-653.
- Carr, A. J., Hopkins, W. G., and Gore, C. J. Effects of acute alkalosis and acidosis on performance: a meta-analysis. Sports Med 2011;41(10):801-814.
- Matson, L. G. and Tran, Z. V. Effects of sodium bicarbonate ingestion on anaerobic performance: a meta-analytic review. Int J Sport Nutr 1993;3(1):2-28.
- Thong, S., Hooper, W., Xu, Y., Ghassemi, A., and Winston, A. Enhancement of plaque removal by baking soda toothpastes from less accessible areas in the dentition. J Clin Dent 2011;22(5):171-178.
- Proudfoot, A. T., Krenzelok, E. P., and Vale, J. A. Position Paper on urine alkalinization. J Toxicol Clin Toxicol 2004;42(1):1-26.
- Kunadian, V., Zaman, A., Spyridopoulos, I., and Qiu, W. Sodium bicarbonate for the prevention of contrast induced nephropathy: a meta-analysis of published clinical trials. Eur J Radiol 2011;79(1):48-55.
- Kanbay, M., Covic, A., Coca, S. G., Turgut, F., Akcay, A., and Parikh, C. R. Sodium bicarbonate for the prevention of contrast-induced nephropathy: a meta-analysis of 17 randomized trials. Int Urol Nephrol 2009;41(3):617-627.
- Hogan, S. E., L'Allier, P., Chetcuti, S., Grossman, P. M., Nallamothu, B. K., Duvernoy, C., Bates, E., Moscucci, M., and Gurm, H. S. Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis. Am Heart J 2008;156(3):414-421.
- Trivedi, H., Nadella, R., and Szabo, A. Hydration with sodium bicarbonate for the prevention of contrast-induced nephropathy: a meta-analysis of randomized controlled trials. Clin Nephrol 2010;74(4):288-296.
- Brar, S. S., Hiremath, S., Dangas, G., Mehran, R., Brar, S. K., and Leon, M. B. Sodium bicarbonate for the prevention of contrast induced-acute kidney injury: a systematic review and meta-analysis. Clin J Am Soc Nephrol 2009;4(10):1584-1592.
- Navaneethan, S. D., Singh, S., Appasamy, S., Wing, R. E., and Sehgal, A. R. Sodium bicarbonate therapy for prevention of contrast-induced nephropathy: a systematic review and meta-analysis. Am J Kidney Dis 2009;53(4):617-627.
- Hoste, E. A., De Waele, J. J., Gevaert, S. A., Uchino, S., and Kellum, J. A. Sodium bicarbonate for prevention of contrast-induced acute kidney injury: a systematic review and meta-analysis. Nephrol Dial Transplant 2010;25(3):747-758.
- Zoungas, S., Ninomiya, T., Huxley, R., Cass, A., Jardine, M., Gallagher, M., Patel, A., Vasheghani-Farahani, A., Sadigh, G., and Perkovic, V. Systematic review: sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy. Ann Intern Med 2009;151(9):631-638.
- Fitzgibbons, L. J. and Snoey, E. R. Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose. J Emerg Med 1999;17(1):57-61.
- Woolf, A. D., Erdman, A. R., Nelson, L. S., Caravati, E. M., Cobaugh, D. J., Booze, L. L., Wax, P. M., Manoguerra, A. S., Scharman, E. J., Olson, K. R., Chyka, P. A., Christianson, G., and Troutman, W. G. Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2007;45(3):203-233.
- Barna, P. Sodium bicarbonate: burst stomachs and high sodium. J Clin Gastroenterol 1986;8(6):697-698.
- Mastrangelo, M. R. and Moore, E. W. Spontaneous rupture of the stomach in a healthy adult man after sodium bicarbonate ingestion. Ann Intern Med 1984;101(5):649-650.
- Salerno, D. M., Murakami, M. M., Johnston, R. B., Keyler, D. E., and Pentel, P. R. Reversal of flecainide-induced ventricular arrhythmia by hypertonic sodium bicarbonate in dogs. Am J Emerg Med 1995;13(3):285-293.
- Hughes, G. S., Heald, D. L., Barker, K. B., Patel, R. K., Spillers, C. R., Watts, K. C., Batts, D. H., and Euler, A. R. The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin Pharmacol Ther 1989;46(6):674-685.
- Neuvonen, P. J. and Karkkainen, S. Effects of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics. Clin Pharmacol Ther 1983;33(3):386-393.
- O'Neil-Cutting, M. A. and Crosby, W. H. The effect of antacids on the absorption of simultaneously ingested iron. JAMA 1986;255(11):1468-1470.
- Okuda, Y., Adrogue, H. J., Field, J. B., Nohara, H., and Yamashita, K. Counterproductive effects of sodium bicarbonate in diabetic ketoacidosis. J Clin Endocrinol Metab 1996;81(1):314-320.
- Meier, P., Ko, D. T., Tamura, A., Tamhane, U., and Gurm, H. S. Sodium bicarbonate-based hydration prevents contrast-induced nephropathy: a meta-analysis. BMC Med 2009;7:23.
- Proudfoot AT, Krenzelok EP, Brent J, Vale JA. Does urine alkalinization increase salicylate elimination? If so, why? Toxicol Rev 2003;22(3):129-36.
- Neavyn MJ, Boyer EW, Bird SB, Babu KM. Sodium acetate as a replacement for sodium bicarbonate in medical toxicology: a review. J Med Toxicol 2013;9(3):250-4.
- Brater DC, Kaojarern S, Benet LZ, et al. Renal excretion of pseudoephedrine. Clin Pharmacol Ther 1980;28(5):690-4.
- Lemmon WT, Paschal GW Jr. Rupture of the stomach following ingestion of sodium bicarbonate. Ann Surg 1941;114(6):997-1003.
- Zer M, Chaimoff C, Dintsman M. Spontaneous rupture of the stomach following ingestion of sodium bicarbonate. Arch Surg 1970;101(4):532-3.
- Brismar B, Strandberg A, Wiklund B. Stomach rupture following ingestion of sodium bicarbonate. Acta Chir Scand Suppl 1986;530:97-9.
- Keane EM, Wilson H, McGrane D, Coakley D, Walsh JB. Use of solvents to disperse ear wax. Br J Clin Pract 1995;49:71-2.
- Carr MM, Smith RL. Ceruminolytic efficacy in adults versus children. J Otolaryngol 2001;30:154-6.
- Fraser JG. The efficacy of wax solvents: in vitro studies and a clinical trial. J Laryngol Otol 1970;84:1055-64.
- Brady JP, Hasbargen JA. Correction of metabolic acidosis and its effect on albumin in chronic hemodialysis patients. Am J Kidney Dis 1998;31(1):35-40.
- Szeto CC, Wong TY, Chow KM, Leung CB, Li PK. Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: a randomized placebo-control trial. J Am Soc Nephrol 2003;14(8):2119-26.
- Thomas SH, Stone CK. Acute toxicity from baking soda ingestion. Am J Emerg Med 1994;12(1):57-9.
- TITLE 21--FOOD AND DRUGS. CHAPTER I--FOOD AND DRUG ADMINISTRATION DEPARTMENT OF HEALTH AND HUMAN SERVICES. SUBCHAPTER D--DRUGS FOR HUMAN USE. PART 331 - ANTACID PRODUCTS FOR OVER-THE-COUNTER (OTC) HUMAN USE. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?cfrpart=331&showfr=1
- Food and Drug Administration Department of Health and Human Services. 21 CFR Part 331. Antacid Drug Products for Over-the-Counter Human Use; Amendment to Antacid Final Monograph; Proposed Rule. Federal Register. 1994;59(22):5060-5065.
- Gonzalez J, Hogg R. Metabolic alkalosis secondary to baking soda treatment of a diaper rash. Pediatrics. 1981;67:820-822.
- Mahadevan U. Gastrointestinal medications in pregnancy. Best Pract Res Clin Gastroenterol. 2007;21(5):849-77.
- Johnson BE. Resistant hypertension due to pica (baking soda). Lancet. 1989 Mar 11;1(8637):550-1.
- Lowder SC, Brown RD. Hypertension corrected by discontinuing chronic sodium bicarbonate ingestion. Subsequent transient hypoaldosteronism. Am J Med. 1975 Feb;58(2):272-9.
- Mc Naughton LR, Dalton B, Tarr J, Buck D. Neutralize acid to enhance performance. Sportscience Training & Technology. 1997. Available at: https://www.sportsci.org/traintech/buffer/lrm.htm
- Saunders B, Elliott-Sale K, Artioli GG, et al. ß-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med 2017;51(8):658-69.
- Giacoppo D, Gargiulo G, Buccheri S, et al. Preventive strategies for contrast-induced acute kidney injury in patients undergoing percutaneous coronary procedures: evidence from a hierarchical Bayesian network meta-analysis of 124 trials and 28,240 patients. Circ Cardiovasc Interv. 2017 May;10(5).
- Akwagyiram I, Butler A, Maclure R, Colgan P, Yan N, Bosma ML. A randomised clinical trial to evaluate the effect of a 67 % sodium bicarbonate-containing dentifrice on 0.2 % chlorhexidine digluconate mouthwash tooth staining. BMC Oral Health. 2016;16(1):79.
- DeClerck MP, Bailey Y, Craig D, et al. Efficacy of topical treatments for Chrysaora chinensis species: A human model in comparison with an in vitro model. Wilderness Environ Med. 2016;27(1):25-38.
- Cantore S, Ballini A, Mori G, et al. Anti-plaque and antimicrobial efficiency of different oral rinses in a 3-day plaque accumulation model. J Biol Regul Homeost Agents. 2016;30(4):1173-1178.
- Driller MW, Gregory JR, Williams AD, Fell JW. The effects of chronic sodium bicarbonate ingestion and interval training in highly trained rowers. Int J Sport Nutr Exerc Metab. 2013;23(1):40-7.
- Chen X, Huang T, Cao X, Xu G. Comparative efficacy of drugs for preventing acute kidney injury after cardiac surgery: A network meta-analysis. Am J Cardiovasc Drugs. 2018;18(1):49-58.
- Sparks A, Williams E, Robinson A, et al. Sodium bicarbonate ingestion and individual variability in time-to-peak pH. Res Sports Med. 2017;25(1):58-66.
- Jones RL, Stellingwerff T, Artioli GG, Saunders B, Cooper S, Sale C. Dose-response of sodium bicarbonate ingestion highlights individuality in time course of blood analyte responses. Int J Sport Nutr Exerc Metab. 2016;26(5):445-453.
- Ghassemi A, Vorwerk L, Cirigliano A, et al. Clinical effectiveness evaluation of a new whitening dentifrice. J Clin Dent. 2015;26(3):66-71.
- Berry AM. A comparison of Listerine® and sodium bicarbonate oral cleansing solutions on dental plaque colonisation and incidence of ventilator associated pneumonia in mechanically ventilated patients: a randomised control trial. Intensive Crit Care Nurs. 2013;29(5):275-81.
- Lomax A, Patel S, Wang N, et al. A randomized controlled trial evaluating the efficacy of a 67% sodium bicarbonate toothpaste on gingivitis. Int J Dent Hyg. 2017;15(4):e35-e41.
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Academies Press (US); 2019 Mar 5.
- Jose A, Parkinson CR, Manger C, Bielfeldt S, Krause C. Randomized Clinical Dose-Response Study to Evaluate Plaque Removal by Three Experimental Sodium Bicarbonate Toothpastes Using a Single Brushing Model. J Clin Dent. 2018;29(4):75-80.
- Lopes-Silva JP, Reale R, Franchini E. Acute and chronic effect of sodium bicarbonate ingestion on Wingate test performance: a systematic review and meta-analysis. J Sports Sci. 2019;37(7):762-771.
- BiCARB study group. Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial. BMC Med. 2020 Apr 9;18(1):91.
- Timal RJ, Kooiman J, Sijpkens YWJ, et al. Effect of no prehydration vs sodium bicarbonate prehydration prior to contrast-enhanced computed tomography in the prevention of postcontrast acute kidney injury in adults with chronic kidney disease: The Kompas Randomized Clinical Trial. JAMA Intern Med. 2020 Apr 1;180(4):533-541.
- Grgic J, Garofolini A, Pickering C, Duncan MJ, Tinsley GM, Del Coso J. Isolated effects of caffeine and sodium bicarbonate ingestion on performance in the Yo-Yo test: A systematic review and meta-analysis. J Sci Med Sport. 2020 Jan;23(1):41-47.
- McKay AKA, Peeling P, Binnie MJ, et al. Topical sodium bicarbonate: No improvement in blood buffering capacity or exercise performance. Int J Sports Physiol Perform. 2020 Jun 22:1-7.
- Durkalec-Michalski K, Nowaczyk PM, Adrian J, Kaminska J, Podgórski T. Nutr Metab (Lond). The influence of progressive-chronic and acute sodium bicarbonate supplementation on anaerobic power and specific performance in team sports: a randomized, double-blind, placebo-controlled crossover study. 2020 May 24;17:38.
- Gurton WH, Gough LA, Sparks SA, Faghy MA, Reed KE. Sodium bicarbonate ingestion improves time-to-exhaustion cycling performance and alters estimated energy system contribution: A dose-response investigation. Front Nutr. 2020 Sep 8;7:154.
- Melamed ML, Horwitz EJ, Dobre MA, et al. Effects of sodium bicarbonate in CKD stages 3 and 4: A randomized, placebo-controlled, multicenter clinical trial. Am J Kidney Dis. 2020 Feb;75(2):225-234.
- Grgic J, Rodriguez RF, Garofolini A, et al. Effects of sodium bicarbonate supplementation on muscular strength and endurance: A systematic review and meta-analysis. Sports Med. 2020 Jul;50(7):1361-1375.
- Hilton NP, Leach NK, Craig MM, Sparks SA, McNaughton LR. Enteric-coated sodium bicarbonate attenuates gastrointestinal side-effects. Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-7.
- Grgic J. Effects of Sodium bicarbonate ingestion on measures of wingate test performance: A meta-analysis. J Am Coll Nutr 2020.
- Ragone L, Guilherme Vieira J, Camaroti Laterza M, et al. Acute effect of sodium bicarbonate supplementation on symptoms of gastrointestinal discomfort, acid-base balance, and performance of jiu-jitsu athletes. J Hum Kinet 2020;75:85-93.
- Boegman S, Stellingwerff T, Shaw G, et al. The impact of individualizing sodium bicarbonate supplementation strategies on world-class rowing performance. Front Nutr 2020;7:138.
- Chang CY, Wu PH, Hsiao CT, Chang CP, Chen YC, Wu KH. Sodium bicarbonate administration during in-hospital pediatric cardiac arrest: A systematic review and meta-analysis. Resuscitation 2021;162:188-197.
- Alshahrani MS, Aldandan HW. Use of sodium bicarbonate in out-of-hospital cardiac arrest: a systematic review and meta-analysis. Int J Emerg Med 2021;14(1):21.
- Calvo JL, Xu H, Mon-López D, Pareja-Galeano H, Jiménez SL. Effect of sodium bicarbonate contribution on energy metabolism during exercise: a systematic review and meta-analysis. J Int Soc Sports Nutr 2021;18(1):11.
- Grgic J, Mikulic P. Ergogenic effects of sodium bicarbonate supplementation on middle-, but not short-distance swimming tests: A Meta-Analysis. J Diet Suppl 2021.
- Grgic J, Pedisic Z, Saunders B, et al. International society of sports nutrition position stand: sodium bicarbonate and exercise performance. J Int Soc Sports Nutr 2021;18(1):61.
- Gaggl M, Repitz A, Riesenhuber S, et al. Effect of oral sodium bicarbonate treatment on 24-hour ambulatory blood pressure measurements in patients with chronic kidney disease and metabolic acidosis. Front Med (Lausanne) 2021;8:711034.
- Saunders B, Oliveira LF, Dolan E, et al. Sodium bicarbonate supplementation and the female athlete: A brief commentary with small scale systematic review and meta-analysis. Eur J Sport Sci. 2021:1-10.
- Turnes T, Cruz RSO, Caputo F, De Aguiar RA. The impact of preconditioning strategies designed to improve 2000-m rowing ergometer performance in trained rowers: A systematic review and meta-analysis. Int J Sports Physiol Perform. 2019;14(7):871-879.
- Maconochie IK, Aickin R, Hazinski MF, et al. Pediatric life support: 2020 International Consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation. 2020;142(16_suppl_1):S140-S184.
- Hughes A, Brown A, Valento M. Hemorrhagic encephalopathy from acute baking soda ingestion. West J Emerg Med. 2016;17(5):619-22.
- Mazzarello V, Piu G, Ferrari M, Piga G. Efficacy of a topical formulation of sodium bicarbonate in mild to moderate stable plaque psoriasis: a randomized, blinded, intrapatient, controlled study. Dermatol Ther (Heidelb). 2019;9(3):497-503.
- Bradberry SM, Thanacoody HK, Watt BE, Thomas SH, Vale JA. Management of the cardiovascular complications of tricyclic antidepressant poisoning : role of sodium bicarbonate. Toxicol Rev. 2005;24(3):195-204.
- Bruccoleri RE, Burns MM. A literature review of the use of sodium bicarbonate for the treatment of QRS widening. J Med Toxicol. 2016;12(1):121-9.
- Sng M, Wiseman J, Liew J, Teixeira RP. Beware of household remedies. You may get burned! Burns Open. 2019;3(3):96-8.
- Kourtellidou SI, Ashby DR, Johansson LR. Oral sodium bicarbonate in people on haemodialysis: a randomised controlled trial. BMC Nephrol 2021;22(1):346.
- Mohammadi F, Oshvandi K, Kamallan SR, et al. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy. Nurs Open 2022;9(3):1602-1611.
- Miranda WAS, Barreto LBM, Miarka B, et al. Can sodium bicarbonate supplementation improve combat sports performance? A systematic review and meta-analysis. Curr Nutr Rep 2022;11(2):273-282.
- Taschieri S, Tumedei M, Francetti L, Corbella S, Del Fabbro M. Efficacy of 67% sodium bicarbonate toothpaste for plaque and gingivitis control: A systematic review and meta-analysis. J Evid Based Dent Pract 2022;22(2):101709.
- Touron M, Javaudin F, Lebastard Q, et al. Effect of sodium bicarbonate on functional outcome in patients with out-of-hospital cardiac arrest: a post-hoc analysis of a French and North-American dataset. Eur J Emerg Med 2022;29(3):210-220.