Senega
OTHER NAME(S): Chinese Senega, Gua-zi-jin, Herbe au Lait, Klapperschlangen, Laitier, Milkwort, Mountain Polygala, Polygala, Polygala de Sénéca, Polygala Glomerata, Polygala Reinii, Polygala Root, Polygala Sénéca, Polygalae Radix, Racine de Polygala, Racine de Serpent à Sonnettes, Radix Polygalae, Rattlesnake Root, Senaga Snakeroot, Seneca, Sénéca, Seneca Snakeroot, Senega Snakeroot, Seneka, Snake Root, Yuan Zhi, Polygala japonica, Polygala senega, Polygala tenuifolia, Polygala de Virginie
Overview
Senega is a plant. The root is used to make medicine.
Senega is used for decline in memory and thinking skills that occurs normally with age, asthma, swelling (inflammation) of the throat, nose, and chest, and many other conditions, but there is no good scientific evidence to support these uses.
Coronavirus disease 2019 (COVID-19): Some experts warn that senega may interfere with the body's response against COVID-19. There is no strong data to support this warning. But there is also no good data to support using senega for COVID-19. Follow healthy lifestyle choices and proven prevention methods instead.
The chemicals in senega irritate the lining of the stomach and lungs. Some chemicals in senega protect cells in the brain.
The chemicals in senega irritate the lining of the stomach and lungs. Some chemicals in senega protect cells in the brain.
Uses
Insufficient Evidence for
- Decline in memory and thinking skills that occurs normally with age. Taking senega might improve some thinking skills by a small amount in elderly adults with memory complaints.
- Memory. Taking senega does not seem to improve memory in healthy adults. But it might help with short-term recall by a small amount.
- Asthma.
- Emphysema.
- Bronchitis.
- Swelling (inflammation) of the throat, nose, and chest.
- Other conditions.
More evidence is needed to rate the effectiveness of senega for these uses.
Side Effects
When taken by mouth: Senega is POSSIBLY SAFE when taken by mouth for up to 8 weeks. But it is POSSIBLY UNSAFE to use senega for more than 8 weeks. Long-term use may cause stomach irritation, diarrhea, dizziness, nausea, and vomiting.
When applied to the skin: There isn't enough reliable information to know if senega is safe or what the side effects might be.
Precautions
When taken by mouth: Senega is POSSIBLY SAFE when taken by mouth for up to 8 weeks. But it is POSSIBLY UNSAFE to use senega for more than 8 weeks. Long-term use may cause stomach irritation, diarrhea, dizziness, nausea, and vomiting.
When applied to the skin: There isn't enough reliable information to know if senega is safe or what the side effects might be.
Pregnancy: It's LIKELY UNSAFE to take senega by mouth if you are pregnant. Senega might make the uterus contract, and it might also start menstruation. These effects could cause a miscarriage. There isn't enough reliable information to know if senega is safe to apply to the skin when pregnant. Stay on the safe side and avoid use.
Breast-feeding: There isn't enough reliable information to know if senega is safe to use when breast-feeding. Stay on the safe side and avoid use.
Fever: Senega can affect the central nervous system. Don't use it if you have a fever.
Stomach and intestinal conditions including peptic ulcers, ulcerative colitis, and Crohn disease: Don't use senega if you have one of these conditions. It can irritate the intestine.
Interactions
We currently have no information for Senega overview.
Dosing
The appropriate dose of senega depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for senega. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
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- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
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- Park HK, Jeon SG, Kim TB, et al. Occupational asthma and rhinitis induced by a herbal medicine, Wonji (Polygala tenuifolia). J Korean Med Sci. 2005;20(1):46-9.
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- Liang Z, Shi F, Wang Y, et al. Neuroprotective effects of tenuigenin in a SH-SY5Y cell model with 6-OHDA-induced injury. Neurosci Lett. 2011;497(2):104-9.
- Hu Y, Liu MY, Liu P, Dong X, Boran AD. Neuroprotective effects of 3,6'-disinapoyl sucrose through increased BDNF levels and CREB phosphorylation via the CaMKII and ERK1/2 pathway. J Mol Neurosci. 2014;53(4):600-7.
