Schizonepeta
OTHER NAME(S): Cataire Japonaise, Chataire Japonaise, Hairy Sage, Herba Schizonepetae, Hjonggae, Hyonggae, Japanese Catnip, Japanese Mint, Jing Jie, Keigai, Jingjie, Schizonepeta Spica, Schizonepetae Herba, Tenuifolia, Trefliksnepeta, Schizonepeta tenuifolia, Schizonepeta multifida, Nepeta multifida, Chataire japonaise
Overview
Schizonepeta is a plant. The parts that grow above the ground are used to make medicine.
Schizonepeta is used for the common cold, fever, sore throat, pain, eczema (atopic dermatitis), psoriasis, and many other conditions, but there is no good scientific evidence to support these uses.
Schizonepeta contains chemicals that might reduce swelling and allergic reactions.
Schizonepeta contains chemicals that might reduce swelling and allergic reactions.
Uses
Insufficient Evidence for
- Eczema (atopic dermatitis). Some research shows that schizonepeta in combination with 9 other herbs (Zemaphyte, Phytopharm Plc.) might reduce redness and irritation in people with eczema. However, other research shows no effect.
- Common cold.
- Fever.
- Sore throat.
- Psoriasis.
- Abnormally heavy bleeding during menstrual periods (menorrhagia).
- Other conditions.
More evidence is needed to rate the effectiveness of schizonepeta for these uses.
Side Effects
When taken by mouth: There isn't enough information to know if schizonepeta is safe or what the side effects might be. When taken at high doses, schizonepeta is POSSIBLY UNSAFE and might damage the liver.
Precautions
When taken by mouth: There isn't enough information to know if schizonepeta is safe or what the side effects might be. When taken at high doses, schizonepeta is POSSIBLY UNSAFE and might damage the liver.
Pregnancy and breast-feeding: There isn't enough reliable information to know if schizonepeta is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with SchizonepetaSome medications are changed and broken down by the liver. Schizonepeta might increase how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are broken down by the liver may decrease the effects of some medications. Before taking schizonepeta talk to your healthcare provider if you take any medications that are changed by the liver. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SchizonepetaSome medications are changed and broken down by the liver. Schizonepeta might decrease how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are changed by the liver may increase the effects and side effects of some medications. Before taking schizonepeta, talk to your healthcare provider if you take any medications that are changed by the liver. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
- Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with SchizonepetaSome medications are changed and broken down by the liver. Schizonepeta might decrease how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are changed by the liver may increase the effects and side effects of some medications. Before taking schizonepeta talk to your healthcare provider if you take any medications that are changed by the liver. Some medications that are changed by the liver include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.
- Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with SchizonepetaSome medications are changed and broken down by the liver. Schizonepeta might decrease how quickly the liver breaks down some medications. Taking schizonepeta along with some medications that are broken down by the liver may increase the effects and side effects of some medications. Before taking schizonepeta talk to your healthcare provider if you take any medications that are changed by the liver. Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).
Dosing
The appropriate dose of schizonepeta depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for schizonepeta. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Fung D, Lau CB. Schizonepeta tenuifolia: chemistry, pharmacology, and clinical applications. J Clin Pharmacol 2002;42:30-6.
- Kirby AJ, Schmidt RJ. The antioxidant activity of Chinese herbs for eczema and of placebo herbs--I. J Ethnopharmacol 1997;56:103-8.
- Shin TY, Jeong HJ, Jun SM, et al. Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats. Immunopharmacol Immunotoxicol 1999;21:705-15.
- Tohda C, Kakihara Y, Komatsu K, Kuraishi Y. Inhibitory effects of methanol extracts of herbal medicines on substance P-induced itch-scratch response. Biol Pharm Bull 2000;23:599-601.
- Ding AW, Wu H, Kong LD, et al. [Research on hemostatic mechanism of extracts from carbonized Schizonepeta tenuifolia Brig]. Zhongguo Zhong Yao Za Zhi 1993;18:598-600, 638.
- Lin R, Tian J, Huang G, et al. Analysis of menthol in three traditional Chinese medicinal herbs and their compound formulation by GC-MS. Biomed Chromatogr 2002;16:229-33.
- Zhou S, Koh HL, Gao Y, et al. Herbal bioactivation: the good, the bad and the ugly. Life Sci 2004;74:935-68.
- Sheehan M, Rustin MHA, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13-17.
- Zhang W, Leonard T, Bath-Hextall F, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev 2004;4:CD002291. [RETRACTED].
- Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38:387-92 .
- Liu HN, Jaw SK, Wong CK. Chinese herbs and atopic dermatitis. Lancet 1993;342:1175-6.
- Bao B, Geng T, Cao Y, et al. Effects of schizonepetin on activity of mRNA expression of cytochrome P450 enzymes in rats. Int J Mol Sci. 2012;13(12):17006-18.
- Shan MQ, Qian Y, Yu S, et al. Anti-inflammatory effect of volatile oil from Schizonepeta tenuifolia on carrageenin-induced pleurisy in rats and its application to study of appropriate harvesting time coupled with multi-attribute comprehensive index method. J Ethnopharmacol. 2016;194:580-6.
- Wang BS, Huang GJ, Tai HM, Huang MH. Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq. Food Chem Toxicol. 2012;50(3-4):526-31.
- Choi YY, Kim MH, Kim JH, et al. Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice. Phytother Res. 2013;27(8):1131-5.
- Sheehan MP, Stevens H, Ostlere LS, et al. Follow-up of adult patients with atopic eczema treated with Chinese herbal therapy for 1 year. Clin Exp Dermatol. 1995;20:136-40.