Papain
OTHER NAME(S): Concentré de Protéase Végétale, Papaina, Papainum Crudum, Pepsine Végétale, Plant Protease Concentrate, Protease, Protéase, Vegetable Pepsin, Papaya enzyme, Papaína, Papaïne
Overview
Papain is an enzyme found in the white fluid (latex) that occurs in raw papaya fruit. It is a protease, meaning it breaks down proteins.
Papain contains substances that might help fight infection and heal wounds.
People use papain for dental cavities, shingles, parasite infections, jellyfish stings, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse papain with papaya or American pawpaw. These are not the same. Also don't confuse papain with other proteolytic enzymes (proteases).
Uses
We currently have no information for Papain overview.
Side Effects
When applied to the skin: A solution of papain is possibly safe when used for up to 20 minutes. But applying raw papain or raw papaya fruit to the skin is possibly unsafe. Skin contact with raw papain can cause irritation and skin blisters.
When taken by mouth: Papain is commonly consumed in foods. It is possibly safe when taken as medicine in doses up to 1200 mg daily for up to 9 weeks. But taking very large amounts of papain is possibly unsafe. Very large doses might cause severe throat and stomach damage.
Precautions
When applied to the skin: A solution of papain is possibly safe when used for up to 20 minutes. But applying raw papain or raw papaya fruit to the skin is possibly unsafe. Skin contact with raw papain can cause irritation and skin blisters.
When taken by mouth: Papain is commonly consumed in foods. It is possibly safe when taken as medicine in doses up to 1200 mg daily for up to 9 weeks. But taking very large amounts of papain is possibly unsafe. Very large doses might cause severe throat and stomach damage.
Pregnancy: Taking papain by mouth during pregnancy is possibly unsafe. It might cause birth defects or miscarriage.
Breast-feeding: There isn't enough reliable information to know if papain is safe to use when breast-feeding. Stay on the safe side and stick to food amounts.
Allergy to fig or kiwi fruit: People who are allergic to fig and kiwi might also be allergic to papain.
Interactions
Moderate Interaction
Be cautious with this combination
- Warfarin (Coumadin) interacts with PapainWarfarin is used to slow blood clotting. Papain might increase the effects of warfarin and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin might need to be changed.
Dosing
Papain has most often been used by adults in combination with other ingredients at a dose of 1200 mg by mouth daily for up to 10 weeks. It's also been applied to the skin in a solution. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
References
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Zavadova E, Desser L, Mohr T. Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation. Cancer Biother 1995;10:147-52.
- Diez-Gomez ML, Quirce S, Aragoneses E, Cuevas M. Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain. Ann Allergy Asthma Immunol 1998;80:24-30.
- Raus I. [Clinical studies on Frubienzyme in a controlled double-blind trial]. Fortschr Med 1976;94:1579-82.
- Billigmann P. [Enzyme therapy-an alternative in treatment of herpes zoster. A controlled study of 192 patients]. Fortschr Med 1995;113:43-8.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Bienen H, Raus I. [Therapeutic comparison of throat lozenges; (author's transl)]. MMW Munch Med Wochenschr 1981;123:745-7.
- Desser L, Rehberger A, Paukovits W. Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro. Cancer Biother 1994;9:253-63.
- Okano T. Effects of essential trace elements on bone turnover-in relation to the osteoporosis. Nippon Rinsho 1996;54:148-54.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Starley, I. F., Mohammed, P., Schneider, G., and Bickler, S. W. The treatment of paediatric burns using topical papaya. Burns 1999;25(7):636-639.
- Hellebrekers, B. W., Trimbos-Kemper, T. C., Trimbos, J. B., Emeis, J. J., and Kooistra, T. Use of fibrinolytic agents in the prevention of postoperative adhesion formation. Fertil.Steril. 2000;74(2):203-212.
- Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34.
- Leipner, J., Iten, F., and Saller, R. Therapy with proteolytic enzymes in rheumatic disorders. BioDrugs. 2001;15(12):779-789.
- El Kadi, K. N., Rawlings, A. V., Feinberg, C., Watkinson, A., Nunn, C. C., Battaglia, A., Chandar, P., Richardson, N., and Pocalyko, D. J. Broad specificity alkaline proteases efficiently reduce the visual scaling associated with soap-induced xerosis. Arch Dermatol.Res 2001;293(10):500-507.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial. Radiother.Oncol. 2002;65(1):17-22.
- Nomura, J. T., Sato, R. L., Ahern, R. M., Snow, J. L., Kuwaye, T. T., and Yamamoto, L. G. A randomized paired comparison trial of cutaneous treatments for acute jellyfish (Carybdea alata) stings. Am J Emerg Med 2002;20(7):624-626.
- Pieper, B. and Caliri, M. H. Nontraditional wound care: A review of the evidence for the use of sugar, papaya/papain, and fatty acids. J.Wound.Ostomy.Continence.Nurs. 2003;30(4):175-183.
- Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372.
- Pereira, A. L. and Bachion, M. M. [Wound treatment: scientific production analysis published in the Revista Brasileira de Enfermagem from 1970-2003]. Rev Bras Enferm. 2005;58(2):208-213.
- Glenn, J. Managing a traumatic wound in a geriatric patient. Ostomy.Wound.Manage. 2006;52(4):94-98.
- Matinian, L. A., Nagapetian, KhO, Amirian, S. S., Mkrtchian, S. R., Mirzoian, V. S., and Voskanian, R. M. [Papain phonophoresis in the treatment of suppurative wounds and inflammatory processes]. Khirurgiia (Mosk) 1990;(9):74-76.
- Udod, V. M., Kolos, A. I., and Gritsuliak, Z. N. [Treatment of patients with lung abscess by local administration of papain]. Vestn.Khir.Im I.I.Grek. 1989;142(3):24-27.
- Ross, E. V., Jr., Badame, A. J., and Dale, S. E. Meat tenderizer in the acute treatment of imported fire ant stings. J Am Acad Dermatol. 1987;16(6):1189-1192.
- Rawlings, N. D. and Barrett, A. J. Families of cysteine peptidases. Methods Enzymol. 1994;244:461-486.
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Rawlings, N. D. and Barrett, A. J. Evolutionary families of peptidases. Biochem J 2-15-1993;290 ( Pt 1):205-218.
- Turk, B., Turk, V., and Turk, D. Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors. Biol.Chem. 1997;378(3-4):141-150.
- Mort, J. S. and Buttle, D. J. Cathepsin B. Int J Biochem Cell Biol 1997;29(5):715-720.
- Cygler, M. and Mort, J. S. Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity. Biochimie 1997;79(11):645-652.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12.
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4.
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15.
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. Clin Allergy 1982;12(1):9-17.
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31.
- de Souza TF, Martins ML, Tavares-Silva CM, Fonseca-Gonçalves A, Maia LC. Treatment time, pain experience and acceptability of the technique for caries removal in primary teeth using the ART approach with or without Brix3000™ papain gel: a preliminary randomised controlled clinical trial. Eur Arch Paediatr Dent 2021.
- Ma JW, Hung JL, Takeuchi M, Shieh PC, Horng CT. A New Pharmacological Vitreolysis through the Supplement of Mixed Fruit Enzymes for Patients with Ocular Floaters or Vitreous Hemorrhage-Induced Floaters. J Clin Med 2022;11(22):6710.