Pao Pereira
OTHER NAME(S): Bergibita, Pao, Pao-Pereira, Pau Pereira, Poirier du Brésil, Geissospermum vellosii, Geissospermum laeve, Pao pereira
Overview
Pao pereira (Geissospermum vellosii) is an Amazonian tree native to Brazil. Its bark is used to make medicine.
Pao pereira contains chemicals that might help prevent cancer from growing. It might also help eliminate the parasite that causes malaria.
People sometimes use pao pereira for cancer, constipation, sexual arousal, and many other conditions, but there is no good scientific evidence to support these uses.
Uses
We currently have no information for Pao Pereira overview.
Side Effects
When taken by mouth: There isn't enough reliable information to know if pao pereira is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if pao pereira is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if pao pereira is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
We currently have no information for Pao Pereira overview.
Dosing
There isn't enough reliable information to know what an appropriate dose of pao pereira might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Bemis DL, Capodice JL, Desai M, et al. Beta-carboline alkaloid-enriched extract from the amazonian rain forest tree pao pereira suppresses prostate cancer cells. J Soc Integr Oncol 2009;7(2):59-65.
- Beljanski M, Crochet S, Beljanski MS. PB-100: a potent and selective inhibitor of human BCNU resistant glioblastoma cell multiplication. Anticancer Res 1993;13(6A):2301-8.
- Beljanski M, Beljanski MS. Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class. Exp Cell Biol 1982;50(2):79-87.
- Munoz V, Sauvain M, Bourdy G, et al. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians. J Ethnopharmacol 2000;69(2):127-37.
- Steele JC, Veitch NC, Kite GC, et al. Indole and beta-carboline alkaloids from Geissospermum sericeum. J Nat Prod 2002;65(1):85-8.
- Aurousseau M. [Comparative study of some pharmacodynamic properties of geissospermine and of its products of hydrolysis or reduction]. Ann Pharm Fr 1961;19:515-9.
- Puiseux L, Le Hir A, Goutarel R, et al. [On the alkaloids of "pao-pereira", Geissospermum laeve (Vellozo) Baillon. Note III. Geissoschizoline, apogeissoschizine and geissospermine]. Ann Pharm Fr 1959;17:626-33.
- Rapoport H, Onak T, Hughes NA, Reinecke MG. Alkaloids of Geissospermum vellosii. J Am Chem Soc 1958;80(7):1601-1604.
- Hughes NA, Rapoport H. Flavopereirine, an alkaloids from Geissospermum vellosii. J Am Chem Soc 1958;80(7):1604-1609.
- Dong R, Chen P, Chen Q. Extract of the medicinal plant pao pereira inhibits pancreatic cancer stem-like cell in vitro and in vivo. Integr Cancer Ther. 2018;17(4):1204-1215.
- Liu J, Fang T, Li M, et al. Pao pereira extract attenuates testosterone-induced benign prostatic hyperplasia in rats by inhibiting 5alpha-reductase. Sci Rep. 2019 Dec 23;9(1):19703.
- Chen P, Dong R, Chen Q. Extracts of the Medicinal Plants Pao Pereira and Rauwolfia vomitoria Inhibit Ovarian Cancer Stem Cells In Vitro. Integr Cancer Ther 2022;21:15347354221123019.