Larch Arabinogalactan
OTHER NAME(S): AG, Ara-6, Arabinogalactan de Alerce, Arabinogalactan, Arabinogalactane, Arabinogalactane de Meleze, Arabinogalactane de Mélèze, Arabinogalactin, Arabinogalactine, Dietary Fiber, Fibre Alimentaire, Fibre Soluble, Gmelinii, Gomme de Mélèze, Larch, Larch Gum, Larch Tree, Larix, Lch, Mélèze, Mélèze d'Europe, Mongolian Larch, Mongolian Larchwood, Pinus Larix, Soluble Fiber, Stractan, Western Larch, Western Larch Arabinogalactan, Wood Gum, Wood Sugar, Larix decidua, Larix europaea, Pinus Larix, Larix occidentalis, Larix gmelinii var. gmelinii, Larix dahurica, Abies gmelinii, Larix laricina, Arabinogalactin, Dietary Fibre, Arabinogalactano de alerce, Arabinogalactane De Mélèze
Overview
Arabinogalactan is a starch-like chemical that is found in many plants. It is found in highest concentrations in larch trees. Most of the larch arabinogalactan found in stores is produced from western larch or eastern larch trees. But larch arabinogalactan can also be produced by other larch tree species. Larch arabinogalactan is sometimes used for medicine.
Larch arabinogalactan is used for common cold, flu (influenza), ear infection (otitis media), and many other conditions, but there is no good scientific evidence to support its use.
In foods, larch arabinogalactan is used as a stabilizer, binder, and sweetener.
Larch arabinogalactan is a fiber that ferments in the intestine. It might increase intestinal bacteria, such as lactobacillus, and have other effects that could be beneficial to digestive tract health. There is also information that suggests larch arabinogalactan might boost the immune system and help prevent cancer cells in the liver from growing.
Larch arabinogalactan is a fiber that ferments in the intestine. It might increase intestinal bacteria, such as lactobacillus, and have other effects that could be beneficial to digestive tract health. There is also information that suggests larch arabinogalactan might boost the immune system and help prevent cancer cells in the liver from growing.
Uses
Insufficient Evidence for
- Common cold. Early research shows that taking 4.5 grams of a specific larch arabinogalactan extract daily for 12 weeks does not lower the overall number of colds or reduce cold symptoms in people who frequently suffer from cold symptoms. But more people taking larch arabinogalactan seem to avoid getting the cold compared to people taking a placebo pill.
- High cholesterol. Early research shows that taking larch arabinogalactan does not lower total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, other blood fats called triglycerides, body weight, blood pressure, or sugar levels in healthy people. It is not yet known whether larch arabinogalactan improves these outcomes in people with high cholesterol.
- Ear infection (otitis media).
- Flu (influenza).
- HIV/AIDS.
- Inflammation.
- Liver cancer.
- Liver disease.
- Pneumonia.
- Tetanus.
- Other conditions.
More evidence is needed to rate the effectiveness of larch arabinogalactan for these uses.
Side Effects
When taken by mouth: Larch arabinogalactan is LIKELY SAFE when eaten in food amounts. It's POSSIBLY SAFE when taken in higher doses of 1.5-8.4 grams daily for less than 6 months. It can cause side effects such as bloating and intestinal gas (flatulence). There isn't enough reliable information to know if it is safe to use for longer than 6 months or what the side effects might be.
Precautions
When taken by mouth: Larch arabinogalactan is LIKELY SAFE when eaten in food amounts. It's POSSIBLY SAFE when taken in higher doses of 1.5-8.4 grams daily for less than 6 months. It can cause side effects such as bloating and intestinal gas (flatulence). There isn't enough reliable information to know if it is safe to use for longer than 6 months or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if larch arabinogalactan is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Larch arabinogalactan might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using larch arabinogalactan.
Organ transplant recipients: Larch arabinogalactan might increase the risk of organ transplant rejection. If you have received an organ transplant, don't use larch arabinogalactan until more is known.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications that decrease the immune system (Immunosuppressants) interacts with Larch ArabinogalactanLarch arabinogalactan seems to increase the immune system. By increasing the Larch arabinogalactan seems to increase activity of the immune system. By increasing the immune system, larch arabinogalactan might decrease the effectiveness of medications that decrease the immune system. Some medications that decrease immune system activity include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Dosing
The appropriate dose of larch arabinogalactan depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for larch arabinogalactan. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
- Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
- Anon. Best herb for fighting off colds. Bottom Line 1999;20:1.
- Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
- Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev 2002;7:138-49.
- Kind LS, Macedo-Sobrinho B, Ako D. Enhanced vascular permeability induced in mice by larch arabinogalactan. Immunology 1970;19:799-807.
- Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85.
- Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32.
- Larch arabinogalactan. Altern.Med.Rev. 2000;5(5):463-466.
- Egert, D. and Beuscher, N. Studies on antigen specifity of immunoreactive arabinogalactan proteins extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58(2):163-165.
- Nergard, C. S., Diallo, D., Michaelsen, T. E., Malterud, K. E., Kiyohara, H., Matsumoto, T., Yamada, H., and Paulsen, B. S. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J.Ethnopharmacol. 2004;91(1):141-152.
- Nergard, C. S., Matsumoto, T., Inngjerdingen, M., Inngjerdingen, K., Hokputsa, S., Harding, S. E., Michaelsen, T. E., Diallo, D., Kiyohara, H., Paulsen, B. S., and Yamada, H. Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Carbohydr.Res. 1-17-2005;340(1):115-130.
- Schepetkin, I. A., Faulkner, C. L., Nelson-Overton, L. K., Wiley, J. A., and Quinn, M. T. Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum. Int.Immunopharmacol. 2005;5(13-14):1783-1799.
- Thude, S., Classen, B., Blaschek, W., Barz, D., and Thude, H. Binding studies of an arabinogalactan-protein from Echinacea purpurea to leucocytes. Phytomedicine. 2006;13(6):425-427.
- Hagmar, B., Ryd, W., and Skomedal, H. Arabinogalactan blockade of experimental metastases to liver by murine hepatoma. Invasion Metastasis 1991;11(6):348-355.
- Vince, A. J., McNeil, N. I., Wager, J. D., and Wrong, O. M. The effect of lactulose, pectin, arabinogalactan and cellulose on the production of organic acids and metabolism of ammonia by intestinal bacteria in a faecal incubation system. Br.J.Nutr. 1990;63(1):17-26.
- Beuth, J., Ko, H. L., Schirrmacher, V., Uhlenbruck, G., and Pulverer, G. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Clin.Exp.Metastasis 1988;6(2):115-120.
- Yamada, H., Kiyohara, H., Cyong, J. C., and Otsuka, Y. Structural characterisation of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa. Carbohydr.Res. 2-1-1987;159(2):275-291.
- Uhlenbruck, G., Beuth, J., Oette, K., Roszkowski, W., Ko, H. L., and Pulverer, G. Prevention of experimental liver metastases by arabinogalactan. Naturwissenschaften 1986;73(10):626-627.
- Beuth, J., Ko, H. L., Oette, K., Pulverer, G., Roszkowski, K., and Uhlenbruck, G. Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose. J.Cancer Res.Clin.Oncol. 1987;113(1):51-55.
- Bayliss, C. E. and Houston, A. P. Characterization of plant polysaccharide- and mucin-fermenting anaerobic bacteria from human feces. Appl.Environ.Microbiol. 1984;48(3):626-632.
- Rampton, D. S., Cohen, S. L., Crammond, V. D., Gibbons, J., Lilburn, M. F., Rabet, J. Y., Vince, A. J., Wager, J. D., and Wrong, O. M. Treatment of chronic renal failure with dietary fiber. Clin.Nephrol. 1984;21(3):159-163.
- Salyers, A. A., Arthur, R., and Kuritza, A. Digestion of larch arabinogalactan by a strain of human colonic Bacteroides growing in continuous culture. J.Agric.Food Chem. 1981;29(3):475-480.
- Yamamoto, S., Sakai, I., and Iseki, S. Purification, composition and immunochemical properties of arabinogalactan-protein H active glycopeptides from Euonymus sieboldiana seeds. Immunol.Commun. 1981;10(3):215-236.
- Ambrus, J. L., Ambrus, C. M., Shields, R., Mink, I. B., and Cleveland, C. Effect of galactose and sugar substitutes on blood insulin levels in normal and obese individuals. J.Med. 1976;7(6):429-438.
- Odonmazig, P., Ebringerova, A., Machova, E., and Alfoldi, J. Structural and molecular properties of the arabinogalactan isolated from Mongolian larchwood (Larix dahurica L.). Carbohydr.Res. 1-15-1994;252:317-324.
- Hauer, J. and Anderer, F. A. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol.Immunother. 1993;36(4):237-244.
- Salyers, A. A., Vercellotti, J. R., West, S. E., and Wilkins, T. D. Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon. Appl.Environ.Microbiol. 1977;33(2):319-322.
- Macfarlane, S., McBain, A. J., and Macfarlane, G. T. Consequences of biofilm and sessile growth in the large intestine. Adv.Dent.Res. 1997;11(1):59-68.
- Khvostov MV, Borisov SA, Tolstikova TG, et al. Supramolecular complex of ibuprofen with larch polysaccharide arabinogalactan: studies on bioavailability and pharmacokinetics. Eur J Drug Metab Pharmacokinet 2017 Jun;42(3):431-440.
- Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8.
- Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28.
- Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.
- Kim LS, Burkholder PM, Waters RF. Effects of low-dose larch arabinogalactan from Larix occidentalis: a randomized, double-blind, placebo-controlled pilot study. Complement Health Pract Rev 2002;7(2):221-9.
- GRAS Notices. U.S. Food & Drug Administration Web site. Available at: https://www.accessdata.fda.gov/scripts/fdcc/?set=GRASNotices. Accessed October 2016.
- Udani JK. Immunomodulatory effects of ResistAid ™: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr. 2013;32(5):331-8.