Kaolin
OTHER NAME(S): Argile de Chine, Argilla, Bolus Alba, China Clay, Heavy Kaolin, Kaolin Léger, Kaolin Lourd, Light Kaolin, Porcelain Clay, Silicate d'Aluminium Hydraté, Terre à Porcelaine, White Bole, Hydrated aluminum silicate, Caolín
Overview
Kaolin is a type of clay found in nature. It is sometimes used to make medicine. It is also used as a filler in tablets.
Kaolin is used to stop bleeding and for a condition that involves swelling and sores in the mouth (oral mucositis). It is also used for diarrhea and many other conditions, but there is no good scientific evidence to support most of these uses.
When held in the mouth, a mouthwash containing kaolin produces a protective coating for mouth sores.
When kaolin is applied to wounds it speeds up blood clotting.
When held in the mouth, a mouthwash containing kaolin produces a protective coating for mouth sores.
When kaolin is applied to wounds it speeds up blood clotting.
Uses
Possibly Effective for
- Swelling (inflammation) and sores inside the mouth (oral mucositis). Using kaolin in a mouth rinse seems to decrease the pain of mouth sores caused by radiation treatment.
- Bleeding. Pressing on an artery using a kaolin pad seems to stop bleeding faster than pressing with a regular pad. Also, applying a pad containing kaolin to a surgical wound seems to stop bleeding faster than applying a regular pad.
There is interest in using kaolin for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When taken by mouth: Kaolin is LIKELY SAFE for most people when taken in foods amounts. It is POSSIBLY SAFE when used as kaolin-pectin in medicines and mouthwashes. It can cause some side effects including constipation. Kaolin is POSSIBLY UNSAFE when used in very large amounts on a daily basis. It can cause blockage of the intestines and low blood iron levels.
When applied to the skin: Kaolin is LIKELY SAFE when used in FDA-approved wound dressings.
Precautions
When taken by mouth: Kaolin is LIKELY SAFE for most people when taken in foods amounts. It is POSSIBLY SAFE when used as kaolin-pectin in medicines and mouthwashes. It can cause some side effects including constipation. Kaolin is POSSIBLY UNSAFE when used in very large amounts on a daily basis. It can cause blockage of the intestines and low blood iron levels.
When applied to the skin: Kaolin is LIKELY SAFE when used in FDA-approved wound dressings.
Pregnancy and breast-feeding: Kaolin is LIKELY SAFE when taken by mouth in food amounts. Kaolin is POSSIBLY SAFE when used as kaolin-pectin in medicines.
Interactions
Moderate Interaction
Be cautious with this combination
- Clindamycin (Cleocin) interacts with KaolinKaolin might decrease how quickly the body absorbs clindamycin (Cleocin), an antibiotic. But it probably doesn't decrease the amount of clindamycin (Cleocin) that is absorbed.
- Digoxin (Lanoxin) interacts with KaolinKaolin might decrease the absorption and decrease the effectiveness of digoxin (Lanoxin), a heart medication. To avoid a potential interaction, separate digoxin (Lanoxin) and kaolin doses by at least three hours.
- Quinidine interacts with KaolinKaolin might decrease the absorption and decrease the effectiveness of quinidine (Quinidex), a heart medication. To avoid a potential interaction, separate quinidine (Quinidex) and kaolin doses by at least three hours.
- Trimethoprim (Proloprim) interacts with KaolinKaolin might decrease the absorption and decrease the effectiveness of trimethoprim (Proloprim), an antibiotic. To avoid a potential interaction, separate trimethoprim (Proloprim) and kaolin doses by at least three hours.
Dosing
ADULT
BY MOUTH
- For swelling (inflammation) and sores inside the mouth (oral mucositis): A mouth rinse containing 15 mL of a mixture of kaolin-pectin and diphenhydramine syrup has been used four times a day.
APPLIED TO THE SKIN
- For bleeding: A pad containing kaolin has been applied with pressure to wounds to stop bleeding.
CHILDREN
APPLIED TO THE SKIN
- For bleeding: A pad containing kaolin has been applied to wounds after surgery to stop bleeding.
References
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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- Chiang CY, Chang WT, Ho CH, et al. Radial artery occlusion with a kaolin-filled pad after transradial cardiac catheterization. Medicine (Baltimore) 2018;97(46):e13134. doi: 10.1097/MD.0000000000013134.
- Dokoupil M, Marecová K, Handlos P, Brezina P. Death of a female prostitute due to intestinal obstruction by an unknown substance. J Forensic Sci 2019;64(1):289-91. doi: 10.1111/1556-4029.13824.
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- Hwang YG, Lee JW, Won EA, Han SH. Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatient Clinic. J Diabetes Res 2019;2019:9316380.
- Pawel L, Dagmara GL, Pawel M, Bogumil R, Andrzej B, Sebastian S. Efficacy and safety of kaolin-based hemostatic pad vs. standard mechanical compression following transradial and transulnar access for elective coronary angiography and PCI: RAUL trial substudy. Heart Vessels 2020;35(4):502-508.
- Kim K, Shim H, Jung PY, et al. Effectiveness of kaolin-impregnated hemostatic gauze use in preperitoneal pelvic packing for patients with pelvic fractures and hemodynamic instability: A propensity score matching analysis. PLoS One 2020;15(7):e0236645.
- Attarha BO, Mikulic S, Harris C, Scolapio JS. Kaolin Clay Anemia. Cureus 2021;13(3):e13796.
