Jequirity
OTHER NAME(S): Bead Vine, Black-Eyed Susan, Buddhist Rosary Bead, Chanothi, Chashami -Khurosa, Chunhali, Crab's Eye, Gaunchi, Ghunchi, Grain D'Église, Gumchi, Gunchi, Gundumani, Gunja, Guruginia, Gurugunii, Haricot Paternoster, Herbe de Diable, Herbe du Diable, Indian Bead, Jequirity Bean, Jequirity Seed, Koonch, Kunch, Kundumani, Kunni, Liane Réglisse, Love Bean, Lucky Bean, Mulati, Ojo de Pajaro, Pater Noster, Prayer Beads, Prayer Head, Precatory Bean, Rati, Rati Gedi, Regaliz Americano, Réglisse Marron, Rosary Pea, Saga, Seminole Bead, Shangir, Soldat, Weather Plant, Weglis, Xian Si Zi, Abrus precatorius, Glycine abrus, Abro, Pois Rouge
Overview
Jequirity is a climbing plant. The roots, leaves, and beans have been used as medicine.
Jequirity is poisonous. Despite serious safety concerns, some people take jequirity by mouth for asthma, constipation, liver disease, and other conditions. But there is no good scientific evidence to support these uses.
The jequirity plant contains many chemicals. Some chemicals in the leaves and root may help with allergy symptoms, improve blood sugar levels, slow blood clotting, reduce swelling, and kill bacteria, tapeworms, or cancer cells. Jequirity bean contains abrin, which is toxic to cells in the body.
The jequirity plant contains many chemicals. Some chemicals in the leaves and root may help with allergy symptoms, improve blood sugar levels, slow blood clotting, reduce swelling, and kill bacteria, tapeworms, or cancer cells. Jequirity bean contains abrin, which is toxic to cells in the body.
Uses
Insufficient Evidence for
- Quickening labor.
- Causing an abortion.
- Preventing pregnancy.
- Pain in terminally ill patients.
- Eyeinflammation.
- Asthma.
- Bronchial tube swelling.
- Fever.
- Hepatitis.
- Malaria.
- Seizures.
- Snakebites.
- Sore throat.
- Stomach pain.
- Tapeworms.
- Coughs.
- Common cold.
- Flu.
- Insect bites.
- Gonorrhea.
- Other conditions.
More evidence is needed to rate the effectiveness of jequirity for these uses.
Side Effects
When taken by mouth: Jequirity is LIKELY UNSAFE. Jequirity contains a chemical called abrin. Abrin is a poison and can cause death, even at low doses. Symptoms of toxicity include stomach cramping, followed by vomiting and severe diarrhea that can become bloody. Other symptoms include seizures, weakness, a fast heart rate, and liver or kidney failure. Symptoms can happen within hours or appear up to several days later. Death can occur after 3-4 days of persistent stomach problems and other symptoms.
When seeds come in contact with the skin, they can cause swelling, irritation, and severe eye problems.
Precautions
When taken by mouth: Jequirity is LIKELY UNSAFE. Jequirity contains a chemical called abrin. Abrin is a poison and can cause death, even at low doses. Symptoms of toxicity include stomach cramping, followed by vomiting and severe diarrhea that can become bloody. Other symptoms include seizures, weakness, a fast heart rate, and liver or kidney failure. Symptoms can happen within hours or appear up to several days later. Death can occur after 3-4 days of persistent stomach problems and other symptoms.
When seeds come in contact with the skin, they can cause swelling, irritation, and severe eye problems.
While jequirity bean isn't safe for anyone to take, some people should be particularly careful to avoid use.
Pregnancy and breast-feeding: Jequirity is LIKELY UNSAFE when taken by mouth during pregnancy or breast-feeding. Jequirity contains a chemical called abrin, which is a poison. Also, jequirity might cause labor to start. Avoid use.
Children: Jequirity is UNSAFE in children. Children are attracted to the bright colors of the seed, which is unfortunate since children are particularly sensitive to the toxic effects of jequirity bean. Children can die after swallowing just one seed. If exposure to jequirity bean is suspected, get immediate medical assistance.
Bleeding disorder: Jequirity might slow blood clotting. In theory, this might make bleeding disorders worse.
Diabetes: Jequirity might lower blood sugar. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use jequirity.
Surgery: Jequirity might slow blood clotting or lower blood sugar. In theory, jequirity might increase the risk of bleeding and interfere with blood sugar control during and after surgical procedures. Stop using jequirity at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for diabetes (Antidiabetes drugs) interacts with JequirityJequirity might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking jequirity along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with JequirityJequirity might slow blood clotting. Taking jequirity along with medications that also slow blood clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with JequiritySome medications are changed and broken down by the liver. Jequirity might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Dosing
The appropriate dose of jequirity depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for jequirity. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
- Kuo SC, Chen SC, Chen LH, et al. Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius. Planta Med 1995;61:307-12.
- Wang JP, Hsu MF, Chang LC, et al. Inhibition of plasma extravasation by abruquinone A, a natural isoflavanquinone isolated from Abrus precatorius. Eur J Pharmacol 1995;273:73-81.
- Sullivan G, Chavez PI. Mexican good-luck charm potentially dangerous. Vet Hum Toxicol 1981;23:259-60.
- Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
- Niyogi SK. The toxicology of Abrus precatorius linnaeus. J Forensic Sci 1970;15:529-36.
- Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80.
- Agarwal SS, Ghatak N, Arora RB, Bhardwaj MM. Antifertility activity of the roots of Abrus precatorius, Linn. Pharma Res Comm 1970;2(2):159-163.
- Jang DH, Hoffman RS, Nelson LS. Attempted suicide, by mail order: Abrus precatorius. J Med Toxicol 2010;6(4):427-430.
- Molgaard P, Nielsen SB, Rasmussen DE, et al. Anthelmintic screening of Zimbabwean plants traditionally used against schistosomiasis. J Ethnopharmacol 2001;74(3):257-264.
- Adelowotan O, Aibinu I, Adenipekun E, Odugbemi T. The in-vitro antimicrobial activity of Abrus precatorius (L) fabaceae extract on some clinical pathogens. Niger Postgrad Med J 2008;15(1):32-37.
- Pillay VV, Bhagyanathan PV, Krishnaprasad R, Rajesh RR, Vishnupriya N. Poisoning due to white seed variety of Abrus precatorius. J Assoc Physicians India 2005;53:317-319.
- Georgewill OA, Georgewill UO. Anti-arthritic activity of abrus precatorious in albino rats. Internet J Laboratory Med 2010;4(1).
- Ramnath V, Rekha PS, Kuttan G, Kuttan R. Regulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin. Evid Based Complement Alternat Med 2009;6(2):233-238.
- Bhutia SK, Mallick SK, Maiti S, Mishra D, Maiti TK. Abrus abrin derived peptides induce apoptosis by targeting mitochondria in HeLa cells. Cell Biol Int 2009;33(7):720-727.
- Bhutia SK, Mallick SK, Maiti S, Maiti TK. Inhibitory effect of Abrus abrin-derived peptide fraction against Dalton's lymphoma ascites model. Phytomedicine 2009;16(4):377-385.
- Bhutia SK, Mallick SK, Maiti S, Maiti TK. Antitumor and proapoptotic effect of Abrus agglutinin derived peptide in Dalton's lymphoma tumor model. Chem Biol Interact 2008;174(1):11-18.
- Bhutia SK, Mallick SK, Stevens SM, et al. Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell. Toxicol In Vitro 2008;22(2):344-351.
- Ghosh D, Maiti TK. Immunomodulatory and anti-tumor activities of native and heat denatured Abrus agglutinin. Immunobiology 2007;212(7):589-599.
- Lin JY, Lee TC, Tung TC. Isolation of antitumor proteins abrin-A and abrin-B from Abrus precatorius. Int J Pept Protein Res 1978;12(5):311-317.
- Limmatvapirat C, Sirisopanaporn S, Kittakoop P. Antitubercular and antiplasmodial constituents of Abrus precatorius. Planta Med 2004;70(3):276-278.
- Nwanjo HU. Hypoglycemic and hypolipidemic effects of aqueous extracts of Abrus precatorius Linn seeds in streptozotocin-induced diabetic Wistar rats. J Herbs Spice Med Plants 2008;14(1-2):68-76.
- Bhutia SK, Mallick SK, Maiti TK. In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomedicine 2009;16(8):776-782.
- Tripathi S, Maiti TK. Immunomodulatory role of native and heat denatured agglutinin from Abrus precatorius. Int J Biochem Cell Biol 2005;37(2):451-462.
- Ghosh D, Bhutia SK, Mallick SK, Banerjee I, Maiti, T. K. Stimulation of murine B and T lymphocytes by native and heat-denatured Abrus agglutinin. Immunobiology 2009;214(3):227-234.
- Sahoo R, Hamide A, Amalnath SD, Narayana BS. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila) 2008;46(10):1071-1073.
- Sahni V, Agarwal SK, Singh NP, Sikdar S. Acute demyelinating encephalitis after jequirity pea ingestion (Abrus precatorius). Clin Toxicol (Phila) 2007;45(1):77-79.
- Subrahmanyan D, Mathew J, Raj M. An unusual manifestation of Abrus precatorius poisoning: a report of two cases. Clin Toxicol (Phila) 2008;46(2):173-175.
- Somerset EJ. SELF INFLICTED CONJUNCTIVITIS: An account of cases produced by the jequirity and castor oil seeds. Br J Ophthalmol 1945;29(4):196-204.
- Andrews JA. Jequirity Ophthalmia. Trans Am Ophthalmol Soc 1884;3:679-685.
- Dickers KJ, Bradberry SM, Rice P, Griffiths GD, Vale JA. Abrin poisoning. Toxicol Rev 2003;22(3):137-142.
- Adedapo AA, Omoloye OA, Ohore OG. Studies on the toxicity of an aqueous extract of the leaves of Abrus precatorius in rats. Onderstepoort J Vet Res. 2007;74(1):31-36.
- Cheng J, Lu TH, Liu CL, Lin JY. A biophysical elucidation for less toxicity of agglutinin than abrin-a from the seeds of Abrus precatorius in consequence of crystal structure. J Biomed Sci 2010;17:34.
- Wu JH, Wu AM, Yang Z, et al. Recognition intensities of submolecular structures, mammalian glyco-structural units, ligand cluster and polyvalency in abrin-a-carbohydrate interactions. Biochimie 2010;92(2):147-156.
- Okoko II, Osinubi AA, Olabiyi OO, et al. Antiovulatory and anti-implantation potential of the methanolic extract of seeds of Abrus precatorius in the rat. Endocr Pract 2010;16(4):554-560.
- Sinha S, Mathur RS. Effect of steroidal fraction of seeds of Abrus precatorius Linn. on rat testis. Indian J Exp Biol 1990;28(8):752-756.
- Sinha R. Post-testicular antifertility effects of Abrus precatorius seed extract in albino rats. J Ethnopharmacol 1990;28(2):173-181.
- Rao MV. Antifertility effects of alcoholic seed extract of Abrus precatorius Linn. in male albino rats. Acta Eur Fertil 1987;18(3):217-220.
- Ghosh D, Maiti TK. Effects of native and heat-denatured Abrus agglutinin on tumor-associated macrophages in Dalton's lymphoma mice. Immunobiology 2007;212(8):667-673.
- Ramnath V, Kuttan G, Kuttan R. Effect of abrin on cell-mediated immune responses in mice. Immunopharmacol Immunotoxicol 2006;28(2):259-268.
- Tripathi S, Ghosh D, Maiti TK. Immunostimulatory role of tryptic digest of Abrus agglutinin. Immunopharmacol Immunotoxicol 2004;26(3):411-424.
- Garaniya N, Bapodra A. Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review. Asian Pac J Trop Biomed 2014;4(Suppl 1):S27-34.
- Gul MZ, Ahmad F, Kondapi AK, Qureshi IA, Ghazi IA. Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts--an in vitro study. BMC Complement Altern Med 2013;13:53.
- Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
- Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4.
- Taur DJ, Patil RY. Mast cell stabilizing and antiallergic activity of Abrus precatorius in the management of asthma. Asian Pac J Trop Med 2011;4(1):46-9.
- Umamahesh B, Veeresham C. Antihyperglycemic and insulin secretagogue activities of Abrus precatorius leaf extract. Pharmacognosy Res 2016;8(4):303-8.
- Huang J, Zhang W, Li X, et al. Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report. Medicine (Baltimore). 2017;96(27):e7423.
- Ai C, Miao X, Wang L, He J. Discovery and Activity Evaluation of the Inhibitory Effect of Four Kinds Traditional Chinese Medicine Extracts on the CYP3A4 Enzyme. Comb Chem High Throughput Screen 2022.