IP-6
OTHER NAME(S): Acide Phytique, Calcium Magnesium Inositol Hexaphosphate, Calcium Phytate, Fytic Acid, InsP6, Phytate, Hexaphosphate d'Inositol, Hexaphosphate d'Inositol de Calcium Magnésium, Phytate de Calcium, Phytic Acid, Inositol hexaphosphate, IP6, Ip-6
Overview
IP-6, inositol hexaphosphate, is a vitamin-like substance. It is found in humans, animals, and many plants, especially cereals, nuts, and legumes. It can also be made in a laboratory.
Some people use IP-6 to treat and prevent cancer, to reduce side effects of cancer treatment, for anemia, diabetes, and many other conditions, but there is no good scientific evidence to support these uses.
In manufacturing, IP-6 is added to food to keep it from spoiling.
IP-6 might help treat and prevent cancer by slowing down the production of cancer cells. It might also bind to certain minerals, decreasing the risk of colon cancer. IP-6 is also an antioxidant.
IP-6 might help treat and prevent cancer by slowing down the production of cancer cells. It might also bind to certain minerals, decreasing the risk of colon cancer. IP-6 is also an antioxidant.
Uses
We currently have no information for IP-6 overview.
Side Effects
When taken by mouth: IP-6 is LIKELY SAFE when used in amounts found in foods. IP-6 is POSSIBLY SAFE when used as a medicine, short-term. Taking IP-6, 600 mg two times per day for up to 2 weeks, appears to be safe. There isn't enough reliable information to know if IP-6 is safe when used long-term or in larger amounts.
When applied to the skin: There isn't enough reliable information to know if IP-6 is safe or what the side effects might be.
Precautions
When taken by mouth: IP-6 is LIKELY SAFE when used in amounts found in foods. IP-6 is POSSIBLY SAFE when used as a medicine, short-term. Taking IP-6, 600 mg two times per day for up to 2 weeks, appears to be safe. There isn't enough reliable information to know if IP-6 is safe when used long-term or in larger amounts.
When applied to the skin: There isn't enough reliable information to know if IP-6 is safe or what the side effects might be.
Pregnancy and breast-feeding: IP-6 is LIKELY SAFE for pregnant and breast-feeding women when used in food amounts. But there isn't enough reliable information to know if larger medicinal amounts of IP-6 are safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.
Clotting disorders: IP-6 might slow blood clotting. If you have a clotting disorder, use IP-6 with caution.
Iron-deficiency anemia: IP-6 binds with iron in the gastrointestinal (GI) tract. This reduces the amount of iron that the body absorbs from food and supplements.
Weak and brittle bones (osteoporosis): IP-6 binds with calcium in the gastrointestinal (GI) tract. This reduces the amount of calcium that the body absorbs from food and supplements. This might worsen osteoporosis.
Surgery: Since IP-6 might slow blood clotting, there is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using IP-6 at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with IP-6IP-6 nicotinate might slow blood clotting. Taking IP-6 along with medications that also slow clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Dosing
The appropriate dose of IP-6 depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for IP-6. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 1996;96:1027-39.
- Graf E, Eaton JW. Antioxidant functions of phytic acid. Free Radic Biol Med 1990;8:61-69.
- Shamsuddin AM, Vucenik I, Cole KE. IP6: a novel anti-cancer agent. Life Sci 1997;61:343-54.
- Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr 1995;35:495-508.
- Shamsuddin AM. Metabolism and cellular functions of IP6: a review. Anticancer Res 1999;19:3733-6.
- Shamsuddin AM, Vucenik I. Mammary tumor inhibition by IP6: a review. Anticancer Res 1999;19:3671-4.
- Challa A, Rao DR, Reddy BS. Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. Carcinogenesis 1997;18:2023-6.
- Saied IT, Shamsuddin AM. Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line. Anticancer Res 1998;18:1479-84.
- Thompson LU, Zhang L. Phytic acid and minerals: effect on early markers of risk for mammary and colon carcinogenesis. Carcinogenesis 1991;12:2041-5.
- Vucenik I, Zhang ZS, Shamsuddin AM. IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res 1998;18:4091-6.
- Shamsuddin AM, Yang GY. Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Carcinogenesis 1995;16:1975-9.
- Shamsuddin AM, Elsayed AM, Ullah A. Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate. Carcinogenesis 1988;9:577-80.
- Vucenik I, Podczasy JJ, Shamsuddin AM. Antiplatelet activity of inositol hexaphosphate. Anticancer Res 1999;19:3689-93.
- Jariwalla RJ. Inositol hexaphosphate (IP6) as an anti-neoplastic and lipid-lowering agent. Anticancer Res 1999;19:3699-3702.
- Sandberg AS, Brune M, Carlsson NG, et al. Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans. Am J Clin Nutr 1999;70:240-6.
- Sandstrom B, Sandberg AS. Inhibitory effects of isolated inositol phosphates on zinc absorption in humans. J Trace Elem Electrolytes Health Dis 1992;6:99-103.
- Grases F, Costa-Bauza A. Phytate (IP6) is a powerful agent for preventing calcifications in biological fluids: usefulness in renal lithiasis treatment. Anticancer Res 1999;19:3717-22..
- Grases F, Garcia-Gonzalez R, Torres JJ, Llobera A. Effects of phytic acid on renal stone formation in rats. Scand J Urol Nephrol 1998;32:261-5..
- Vucenik I, Passaniti A, Vitolo MI, et al. Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis 2004;25:2115-23.
- Deliliers GL, Servida F, Fracchiolla NS, et al. Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic haematopoietic cells. Br J Haematol 2002;117:577-87.
- Tantivejkul K, Vucenik I, Eiseman J, Shamsuddin AM. Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer. Breast Cancer Res Treat 2003;79:301-12.
- Proietti S, Pasta V, Cucina A, et al. Inositol hexaphosphate (InsP6) as an effective topical treatment for patients receiving adjuvant chemotherapy after breast surgery. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):43-50.
- Bacic I, Druzijanic N, Karlo R, Skific I, Jagic S. Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study. J Exp Clin Cancer Res. 2010;29:12.
- Wilson MS, Bulley SJ, Pisani F, Irvine RF, Saiardi A. A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine. Open Biol. 2015;5(3):150014.
- Grases F, Simonet BM, Vucenik I, et al. Absorption and excretion of orally administered inositol hexaphosphate (IP(6) or phytate) in humans. Biofactors. 2001;15(1):53-61.
- Ikenaga T, Kakumoto K, Kohda N, Yamamoto T. Effect of Inositol Hexaphosphate (IP6) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Plant Foods Hum Nutr. 2019 Sep;74(3):316-321.
- Amabile MI, De Luca A, Tripodi D, et al. Effects of Inositol Hexaphosphate and Myo-Inositol Administration in Breast Cancer Patients during Adjuvant Chemotherapy. J Pers Med. 2021 Jul 30;11(8):756.
- Alkhalaf MI, Alansari WS, Alshubaily FA, et al. Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats. Sci Rep. 2020 Jul 28;10(1):12599.