Hordenine
OTHER NAME(S): 4-[2-(Dimethylamino)Ethyl]Phenol, 4-hydroxy-N,N-dimethylphenethylamine, Anhaline, Eremursine, P-Hydroxy-N,N-Dimethylphenethylamine, Peyocactin, Peyocactine, N,N-dimethyltyramine, Hordenine HCl, Hordenina, Hordénine
Overview
Hordenine is a chemical naturally found in barley (Hordeum vulgare). It can also be found in algae, cacti, and some grass species. It is similar in chemical structure to stimulants found in bitter orange. Hordenine is included in many dietary supplements used for athletic performance and weight loss.
People take hordenine by mouth for obesity and improving athletic performance, but there is no good scientific evidence to support these uses.
Uses
Insufficient Evidence for
- Athletic performance.
- Obesity.
- Other conditions.
More evidence is needed to rate hordenine for these uses.
Side Effects
When taken by mouth: Hordenine is POSSIBLY UNSAFE. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure.
Precautions
When taken by mouth: Hordenine is POSSIBLY UNSAFE. Hordenine is similar in structure to stimulants found in bitter orange. In theory, hordenine might have similar stimulant effects and side effects such as rapid heart rate and high blood pressure.
Pregnancy and breast-feeding: There isn't enough reliable information to know if hordenine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
High blood pressure: Hordenine is similar to stimulants found in bitter orange. In theory, taking hordenine might make high blood pressure worse.
Kidney stones: Taking hordenine might increase the risk for kidney stones.
Surgery: Hordenine might interfere with surgery by increasing blood pressure and heart rate. Stop taking hordenine at least 2 weeks before surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications for depression (MAOIs) interacts with HordenineHordenine might stimulate the body. Some medications used for depression can increase chemicals that also have stimulant effects. Taking hordenine with these medications used for depression might cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others. Some of these medications used for depression include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate).
- Stimulant drugs interacts with HordenineStimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Hordenine might also speed up the nervous system. In theory, taking hordenine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with hordenine. Some stimulant drugs include amphetamine, caffeine, methylphenidate, pseudoephedrine, and many others.
Dosing
The appropriate dose of hordenine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hordenine (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
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- Dietary Ingredient - Hordenine. Dietary Supplement Label Database. National Institutes of Health Web site. Available at: https://www.dsld.nlm.nih.gov/dsld/rptIngredient.jsp?db=adsld&item=HORDENINE. Accessed November 18, 2015.
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- Sobiech M, Giebultowicz J, Lulinski P. Application of magnetic core-shell imprinted nanoconjugates for the analysis of hordenine in human plasma - preliminary data on pharmacokinetic study after oral administration. J Agric Food Chem. 2020 Dec 9;68(49):14502-12.