Graviola
OTHER NAME(S): Brazilian Cherimoya, Brazilian Paw Paw, Corossol, Corossol Épineux, Durian Benggala, Ekitafeli, Guanabana, Guanábana, Guanavana, Nangka Blanda, Nangka Londa, Omusitafeli, Paw-Paw, Prickly Custard, Sirsak, Soursop, Sour Sop, Toge-Banreisi, Annona muricata, Annona macrocarpa, Annona cherimola, Corossolier
Overview
Graviola (Annona muricata) is a small tree native to tropical regions. It makes edible fruit and has been used traditionally for parasite infections.
Graviola contains chemicals that might help fight against cancer, as well as bacteria, viruses, and parasites.
People use graviola for human papilloma virus (HPV), bacterial infections, cancer, and many other conditions, but there is no good scientific evidence to support these uses. It also might be unsafe.
Uses
We currently have no information for Graviola overview.
Side Effects
When taken by mouth: Graviola is possibly unsafe. Taking larger amounts of the fruit or regularly drinking tea made from the leaves has been linked to movement disorders similar to Parkinson disease.
Precautions
When taken by mouth: Graviola is possibly unsafe. Taking larger amounts of the fruit or regularly drinking tea made from the leaves has been linked to movement disorders similar to Parkinson disease.
Pregnancy and breast-feeding: Do not use graviola. It is possibly unsafe when taken by mouth.
Parkinson disease: Graviola might make the symptoms of Parkinson disease worse.
Interactions
Moderate Interaction
Be cautious with this combination
- Carbamazepine (Tegretol) interacts with GraviolaGraviola may reduce how much carbamazepine is in the body. Taking graviola with carbamazepine might decrease the effects of this medication.
Dosing
There isn't enough reliable information to know what an appropriate dose of graviola might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6.
- Padma P, Pramod NP, Thyagarajan SP, Khosa RL. Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus. J Ethnopharmacol 1998;61:81-3.
- Roman G. Tropical myeloneuropathies revisited. Curr Opin Neurol 1998;11:539-44.
- Oberlies NH, Chang CJ, McLaughlin JL. Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. J Med Chem 1997;40:2102-6.
- Jaramillo MC, Arango GJ, Gonzalez MC, et al. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia 2000;71:183-6.
- Lannuzel A, Michel PP, Caparros-Lefebvre D, et al. Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord 2002;17:84-90.
- dos Santos AF, Sant'Ana AE. Molluscicidal properties of some species of Annona. Phytomedicine 2001;8:115-20..
- Champy, P., Hoglinger, G. U., Feger, J., Gleye, C., Hocquemiller, R., Laurens, A., Guerineau, V., Laprevote, O., Medja, F., Lombes, A., Michel, P. P., Lannuzel, A., Hirsch, E. C., and Ruberg, M. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J.Neurochem. 2004;88(1):63-69.
- Lannuzel, A., Hoglinger, G. U., Champy, P., Michel, P. P., Hirsch, E. C., and Ruberg, M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? J.Neural Transm.Suppl 2006;(70):153-157.
- Moghadamtousi SZ, Fadaeinasab M, Nikzad S, Mohan G, Ali HM, Kadir HA. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. Int J Mol Sci. 2015 Jul 10;16(7):15625-58. doi: 10.3390/ijms160715625.
- Atlas RO, Lemus J, Reed J 3rd, Atkins D, Alger LS. Second trimester abortion using prostaglandin E2 suppositories with or without intracervical Laminaria japonica: a randomized study. Obstet Gynecol. 1998 Sep;92(3):398-402
- Hansra DM, Silva O, Mehta A, Ahn E. Patient with metastatic breast cancer achieves stable disease for 5 years on graviola and xeloda after progressing on multiple lines of therapy. Adv Breast Cancer Res. 2014;3:84-7.
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835-48.
- Bonneau N, Le Ven J, Schmitz-Afonso I, et al. Annonaceous acetogenins as environmental neurotoxins: Human exposure from edible Annona fruits. Planta Med. 2012;78:PH25. Abstract only.
- Raveloson Ravaomanarivo LH, Andrianiaina Razafindraleva H, Raharimalala FN, Rasoahantaveloniaina B, Ravelonandro PH, Mavingui P. Efficacy of seed extracts of Annona squamosa and Annona muricata (Annonaceae) for the control of Aedes albopictus and Culex quinquefasciatus (Culicidae). Asian Pac J Trop Biomed. 2014;4(10):798-806.
- Indrawati L, Ascobat P, Bela B, Abdullah M, Surono IS. The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pac J Clin Nutr. 2017;26(4):606-12.
- Le Donne M, Lentini M, Alibrandi A, et al. Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial. J Funct Food 2017;35:549-54.
- Sokpe A, Mensah MLK, Koffuor GA, et al. Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products. Evid Based Complement Alternat Med. 2020 Dec 10;2020:8833828.
- Serretta V, Berardinis E, Simonato A, et al. A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis. Urologia. 2021 Jun 2:3915603211022285.
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875.
- La Vignera S, Basile L, Aversa A, et al. The Use of Ellagic Acid and Annona Muricata Improves Semen Quality in Men with High-Risk Papillomavirus Infection. J Clin Med 2022;11(16):4691.
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366.
- Moscato GMF, Galanti F, Criscuolo AA, et al. A retrospective study on two cohorts of immunocompetent women treated with nonavalent HPV vaccine vs. Ellagic acid complex: outcome of the evolution of persistent cervical HPV infection. Eur Rev Med Pharmacol Sci 2022;26(15):5509-5519.