Goat’s Rue
OTHER NAME(S): Faux-Indigo, French Honeysuckle, French Lilac, Galéga Officinal, Galegae Officinalis Herba, Geissrautenkraut, Italian Fitch, Lavanèse, Lilas d'Espagne, Lilas Français, Rue-de-Chèvre, Rue des Chèvres, Sainfoin d'Espagne, Galega officinalis, Galega bicolor, Galega patula, Goats Rue, Goat's Rue Herb, Galega, Galéga
Overview
Goat's rue is a plant. The parts that grow above the ground are used to make medicine. Be careful not to confuse goat's rue (Galega officinalis) with rue (Ruta graveolens).
Goat's rue is used for diabetes, breast-feeding, and many other purposes, but there is no good scientific evidence to support its use.
Goat's rue contains a chemical that may lower blood sugar in a test tube. But it is unclear if goat's rue has this effect when taken by people.
Goat's rue contains a chemical that may lower blood sugar in a test tube. But it is unclear if goat's rue has this effect when taken by people.
Uses
Insufficient Evidence for
- Breast-feeding. Some mothers have reported improvements in milk production after taking goat's rue with other vitamins and minerals, but this has not been studied in clinical trials.
- Diabetes.
- Digestive problems.
- Other uses.
More evidence is needed to rate the effectiveness of goat's rue for these uses.
Side Effects
When taken by mouth: There isn't enough reliable information to know if goat's rue is safe or what the side effects might be. No harmful effects have been reported in humans, but fatal poisoning has occurred in grazing animals that ate large quantities of goat's rue.
Precautions
When taken by mouth: There isn't enough reliable information to know if goat's rue is safe or what the side effects might be. No harmful effects have been reported in humans, but fatal poisoning has occurred in grazing animals that ate large quantities of goat's rue.
Pregnancy and breast-feeding: There isn't enough reliable information to know if goat's rue is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Bleeding conditions: Goat's rue might slow blood clotting and increase the risk of bleeding. In theory, goat's rue might make bleeding disorders worse.
Surgery: Goat's rue might affect blood sugar levels. There is concern that it might interfere with blood sugar control during and after surgery. Stop using goat's rue at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with Goat's RueGoat's rue might slow blood clotting. Taking goat's rue along with medications that also slow blood clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Dosing
The appropriate dose of goat's rue depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for goat's rue. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
References
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Neef H, Augustijns P, Declercq P, et al. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells (Caco-2). Pharm Pharmacol Lett 1996;6:86-9.
- Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
- Huxtable CR, Dorling RR, Colegate SM. Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge). Aust Vet J 1993;70:169-71.
- Lemus, I., Garcia, R., Delvillar, E., and Knop, G. Hypoglycaemic activity of four plants used in Chilean popular medicine. Phytother Res 1999;13(2):91-94.
- Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50.
- Palit, P., Furman, B. L., and Gray, A. I. Novel weight-reducing activity of Galega officinalis in mice. J Pharm Pharmacol. 1999;51(11):1313-1319.
- Champavier, Y., Allais, D. P., Chulia, A. J., and Kaouadji, M. Acetylated and non-acetylated flavonol triglycosides from Galega officinalis. Chem.Pharm Bull.(Tokyo) 2000;48(2):281-282.
- Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240.
- Pundarikakshudu, K., Patel, J. K., Bodar, M. S., and Deans, S. G. Anti-bacterial activity of Galega officinalis L. (Goat's Rue). J Ethnopharmacol. 2001;77(1):111-112.
- Atanasov, A. T., Chorbanov, B. P., and Dimitrov, B. D. Anti-aggregation activity of crude water extract of Galega officinalis L. fractionated on Sephadex G-25 and Sepharose 4B. Folia Med.(Plovdiv.) 2002;44(1-2):45-49.
- Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234.
- PUFAHL, K. and SCHREIBER, K. [Isolation of a new guanidine derivative from goat's rue, Galega officinalis L.]. Experientia 7-15-1961;17:302-303.
- SCHREIBER, K., AURICH, O., and PUFAHL, K. [Isolation of peganine from goat's-rue, Galega officinalis L.]. Arch.Pharm 1962;295/67:271-275.
- LAPYNINA, L. A. [ON FLAVONOID COMPOSITION OF GALEGA OFFICINALIS.]. Farm.Zh. 1965;20:57-62.
- Misbin, R. I. The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 2004;27(7):1791-1793.
- Keeler, R. F., Baker, D. C., and Panter, K. E. Concentration of galegine in Verbesina encelioides and Galega oficinalis and the toxic and pathologic effects induced by the plants. J Environ.Pathol.Toxicol.Oncol. 1992;11(2):11-17.
- Vuksan, V. and Sievenpiper, J. L. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr.Metab Cardiovasc.Dis. 2005;15(3):149-160.
- Hadden, D. R. Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection. J R.Coll.Physicians Edinb. 2005;35(3):258-260.
- Barger, G. and White, F. D. Galuteolin, a New Glucoside from Galega Officinalis. Biochem.J 1923;17(6):836-838.
- Rasekh, H. R., Nazari, P., Kamli-Nejad, M., and Hosseinzadeh, L. Acute and subchronic oral toxicity of Galega officinalis in rats. J Ethnopharmacol. 2-28-2008;116(1):21-26.
- Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L., and Furman, B. L. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br.J Pharmacol. 2008;153(8):1669-1677.
- Keeler, R. F., Baker, D. C., and Evans, J. O. Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L. Vet.Hum.Toxicol. 1988;30(5):420-423.
- Keeler, R. F., Johnson, A. E., Stuart, L. D., and Evans, J. O. Toxicosis from and possible adaptation to Galega officinalis in sheep and the relationship to Verbesina encelioides toxicosis. Vet.Hum.Toxicol. 1986;28(4):309-315.
- Schafer, J. and Stein, M. [On the variability of substances contained in the goat's rue (Galega officinalis L.)]. Naturwissenschaften 1967;54(8):205.
- Gonzalez-Andres, F., Redondo, P. A., Pescador, R., and Urbano, B. Management of Galega officinalis L. and preliminary results on its potential for milk production improvement in sheep. New Zealand Journal of Agricultural Research 2004;47:233-245.
- Petricic, J. and Kalodera, Z. Galegin in the goat's rue herb: toxicity, antidiabetic activity and content determination. Acta Pharm Jugosl 1982;32:219-223.
- Atanasov, A. T. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Medicinal Plant 1995;3:71-76.
- Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
- Cavaliere, C. Glucophage: Diabetic drug based on traditional herb celebrates 50 years of use. HerbalGram 2008;76:44-49.
- Neef, H., Augustijns, P., Declercq, P., Declerck, P. J., and Laekeman, G. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells. Pharmaceutical and Pharmacological Letters 1996;6:86-89.
- Bailey, C. J. and Day, C. Metformin: its botanical background. Pract Diab Int 2004;21(3):115-117.
- Salatino S, Giacomelli L, Carnevali I, Giacomelli E. The role of natural galactagogues during breast feeding: focus on a Galega officinalis based food supplement. Minerva Pediatr. 2017 Dec;69(6):531-537.