Dimethylglycine (DMG)
OTHER NAME(S): Acide Diméthylaminoacétique, Dimethyl Glycine, Diméthylglycine, Dimethylglycine HCl, Diméthylglycine HCl, (Dimethylamino) acetic Acid, Dimetilglicina, DMG, DMG HCl, N,N-dimethylaminoacetic Acid, N,N-diméthylglycine, N,N Dimethylglycine HCl, N,N Diméthylglycine HCl, N-methylsarcosine, N,N-dimethylglycine, Dimethylglycine, N, N-Dimethylglycine, Dimetilglicina (DMG), Diméthylglycine (DMG)
Overview
Dimethylglycine (DMG) is an amino acid, a building block for protein. The body needs dimethylglycine to function.
Dimethylglycine is an essential amino acid, which means that the body cannot make this chemical on its own. It must be consumed in the diet. It is found in grains and meats and can also be taken as a supplement.
People use dimethylglycine for aging, athletic performance, memory and thinking skills (cognitive function), and many other purposes, but there is no scientific evidence to support its use.
Uses
We currently have no information for Dimethylglycine (DMG) overview.
Side Effects
When taken by mouth: Dimethylglycine is possibly safe when used short-term, for up to 28 days. The safety of long-term use is unknown.
Precautions
When taken by mouth: Dimethylglycine is possibly safe when used short-term, for up to 28 days. The safety of long-term use is unknown.
Pregnancy and breast-feeding: There isn’t enough reliable information to know if dimethylglycine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
We currently have no information for Dimethylglycine (DMG) overview.
Dosing
There isn’t enough reliable information to know what an appropriate dose of dimethylglycine might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Bolman WM, Richmond JA. A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder. J Autism Dev Disord 1999;29:191-4.
- Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med 1990;115:481-6.
- Weiss RC. Immunologic responses in healthy random-source cats fed N,N-dimethylglycine-supplemented diets. Am J Vet Res 1992;53:829-33.
- Gascon G, Patterson B, Yearwood K, Slotnick H. N,N-dimethylglycine and epilepsy. Epilepsia 1989;30:90-3.
- Freed WJ. Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine. Pharmacol Biochem Behav 1985;22:641-3.
- Graber CD, Goust JM, Glassman AD, et al. Immunomodulating properties of dimethylglycine in humans. J Infect Dis 1981;143:101-5.
- Roach ES, Carlin L. N,N dimethylglycine for epilepsy [letter]. N Engl J Med 1982;307:1081-2.
- Herbert V. N,N-dimethylglycine for epilepsy [letter]. N Engl J Med 1983;308:527-8.
- Freed WJ. N,N-dimethylglycine, betaine and seizures [letter]. Arch Neurol 1984;41:1129-30.
- Ward TN, Smith EB, Reeves AG. Dimethylglycine and reduction of mortality in penicillin-induced seizures [letter]. Ann Neurol 1985;17:213.
- Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res 1989;222:343-50.
- Wolfsegger T, Böck K, Schimetta W, von Oertzen TJ, Assar H. N,N-Dimethylglycine in patients with progressive multiple sclerosis: result of a pilot double-blind, placebo, controlled randomized clinical trial. Neurol Res Pract 2021;3(1):29.