Diiodothyronine
OTHER NAME(S): 3,5 diiodothyronine, 3,5-L-diiodothyronine, 3,5-T2, T2, T-2, 3,3-diiodo-L-thyronine, u003Cndb:nameu003E3, 5-Diiodo L-Thyronineu003C/ndb:nameu003E, Diyodotironina
Overview
Diiodothyronine is a thyroid hormone. Small amounts are found naturally in the body.
Some research suggests that diiodothyronine might speed up metabolism and reduce fat storage, but it's not clear if these effects are significant.
People use diiodothyronine for obesity, high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia), and for muscle strength, but there is no good scientific evidence to support any use.
Uses
We currently have no information for Diiodothyronine overview.
Side Effects
When taken by mouth: There isn't enough reliable information to know if diiodothyronine is safe or what the side effects might be.
Precautions
When taken by mouth: There isn't enough reliable information to know if diiodothyronine is safe or what the side effects might be.
Pregnancy and breast-feeding: There isn't enough reliable information to know if diiodothyronine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
We currently have no information for Diiodothyronine overview.
Dosing
There isn't enough reliable information to know what an appropriate dose of diiodothyronine might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
- Goglia F. Biological effects of 3,5-diiodothyronine (T(2)). Biochemistry (Mosc) 2005;70:164-72.
- Silvestri E, Schiavo L, Lombardi A, Goglia F. Thyroid hormones as molecular determinants of thermogenesis. Acta Physiol Scand 2005;184:265-83.
- Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol 1997;19:137-47.
- Moreno M, Lombardi A, Lombardi P, et al. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sci 1998;62:2369-77.
- Giudetti AM, Leo M, Geelen MJ, Gnoni GV. Short-term stimulation of lipogenesis by 3,5-L-diiodothyronine in cultured rat hepatocytes. Endocrinology 2005;146:3959-66.
- Lanni A, Moreno M, Lombardi A, et al. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J 2005;19:1552-4.
- da Silva Teixeira S, Filgueira C, Sieglaff DH, et al. 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. Acta Physiol (Oxf) 2017;220(2):238-50. doi: 10.1111/apha.12821.
- Silvestri E, Senese R, Cioffi F, et al. 3,5-Diiodo-L-thyronine exerts metabolically favorable effects on visceral adipose tissue of rats receiving a high-fat diet. Nutrients. 2019 Jan 27;11(2):278.
- Petito G, Cioffi F, Silvestri E, et al. 3,5-Diiodo-L-thyronine (T2) administration affects visceral adipose tissue inflammatory state in rats receiving long-lasting high-fat diet. Front Endocrinol (Lausanne). 2021 Jul 12;12:703170.
- Bouazza A, Favier R, Fontaine E, Leverve X, Koceir EA. Potential Applications of Thyroid Hormone Derivatives in Obesity and Type 2 Diabetes: Focus on 3,5-Diiodothyronine (3,5-T2) in Psammomys obesus (Fat Sand Rat) Model. Nutrients 2022;14(15):3044.