Delta-8-Tetrahydrocannabinol (Delta-8-THC)
OTHER NAME(S): Delta-8-Tetrahydrocannabinol, Delta-8-THC, Diet Weed, Weed Light, Delta-8-tetrahydrocannabinol, Delta 8, Delta-8, Delta-8 THC, Delta-8 Tetrahydrocannabinol, Delta-8-tétrahydrocannabinol (delta-8-THC)
Overview
Delta-8-tetrahydrocannabinol (delta-8-THC) is a cannabinoid from Cannabis sativa. It's similar to delta-9-THC, the main psychoactive compound in cannabis.
Cannabinoids in cannabis work by binding to sites in the brain and on the nerves. Delta-8-THC is similar to delta-9-THC, but appears to be less psychoactive. The natural concentration of delta-8-THC in cannabis and hemp is low, so most delta-8-THC is synthetically made in a lab.
People use delta-8-THC for nausea and vomiting caused by cancer drug treatment, glaucoma, trouble sleeping, and many other conditions, but there is no good scientific evidence to support these uses.
Keep in mind that delta-8-THC hasn't been evaluated by the US FDA for safety, and legality isn't clear. It's banned in some states, and legal in others. Also, the amount of delta-8-THC in products might vary significantly. Some products might also contain contaminants.
Uses
We currently have no information for Delta-8-Tetrahydrocannabinol (Delta-8-THC) overview.
Side Effects
When taken by mouth: There isn't enough reliable information to know if delta-8-THC is safe. It might cause side effects such as difficulty thinking and speaking, and feeling "high." Regular use might also cause cannabinoid hyperemesis syndrome (CHS). CHS leads to severe nausea and vomiting that doesn't respond to typical anti-nausea drugs.
Precautions
When taken by mouth: There isn't enough reliable information to know if delta-8-THC is safe. It might cause side effects such as difficulty thinking and speaking, and feeling "high." Regular use might also cause cannabinoid hyperemesis syndrome (CHS). CHS leads to severe nausea and vomiting that doesn't respond to typical anti-nausea drugs.
Pregnancy and breast-feeding: There isn't enough reliable information to know if delta-8-THC is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Children: Taking delta-8-THC by mouth is possibly unsafe. Delta-8-THC gummies and candies have been eaten by children by mistake, leading to hospitalization. Side effects might include extreme tiredness, low blood pressure, and slowed heart rate.
Interactions
We currently have no information for Delta-8-Tetrahydrocannabinol (Delta-8-THC) overview.
Dosing
Delta-8-THC is available in many different types of products, including foods, dried plant products, and smoking and vaping products. The amount of delta-8-THC in products might vary significantly. Some products might also contain contaminants. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
Keep in mind that delta-8-THC hasn't been evaluated by the US FDA for safety, and legality isn't clear. It's banned in some states, and legal in others.
References
- Crippa JAS, Zuardi AW, Hallak JEC, et al. Oral cannabidiol does not convert to ?(8)-THC or ?(9)-THC in humans: A pharmacokinetic study in healthy subjects. Cannabis Cannabinoid Res 2020;5(1):89-98.
- Loveless SE, Harris LS, Munson AE. Hyporesponsiveness to the immunosuppressant effects of delta-8-tetrahydrocannabinol. J Immunopharmacol 1981;3(3-4):371-83.
- Avraham Y, Ben-Shushan D, Breuer A, et al. Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels following weight loss. Pharmacol Biochem Behav 2004;77(4):675-84.
- Johnson-Arbor K, Smolinske S. The current state of delta-8 THC. Am J Emerg Med 2021.
- Watanabe K, Arai M, Narimatsu S, Yamamoto I, Yoshimura H. Effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, on the hepatic microsomal drug-metabolizing enzyme system of mice. Biochem Pharmacol 1986;35(11):1861-5.
- Czégény Z, Nagy G, Babinszki B, et al. CBD, a precursor of THC in e-cigarettes. Sci Rep 2021;11(1):8951.
- Rosenthal J, Howell M, Earl V, Malik M. Cannabinoid hyperemesis syndrome secondary to delta-8 THC use. Am J Med 2021.
- US Food and Drug Administration (FDA). 5 things to know about delta-8 tetrahydrocannabinol - delta-8 THC. September 2021. https://www.fda.gov/consumers/consumer-updates/5-things-know-about-delta-8-tetrahydrocannabinol-delta-8-thc. Accessed October 2, 2021.
- Centers for Disease Control and Prevention (CDC). Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events. September 2021. https://emergency.cdc.gov/han/2021/han00451.asp. Accessed October 2, 2021.
- Rzeppa S, Große J, Rautenberg C, et al. Emergence of the less common cannabinoid ?8 -Tetrahydrocannabinol in a doping sample. Drug Test Anal. 2021.
- Stout SM, Cimino NM. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014;46(1):86-95.
- Meehan-Atrash J, Rahman I. Novel ?(8)-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals. Chem Res Toxicol 2021.
- Akpunonu P, Baum RA, Reckers A, et al. Sedation and Acute Encephalopathy in a Pediatric Patient Following Ingestion of Delta-8-Tetrahydrocannabinol Gummies. Am J Case Rep 2021;22:e933488.
- Jo NY, Chu CC, Ramsey BC. Brugada Electrocardiogram Pattern Induced by Recreational Delta-8-Tetrahydrocannabinol (THC): A Case Report. Cureus 2021;13(10):e19058.
- Ray CL, Bylo MP, Pescaglia J, Gawenis JA, Greenlief CM. Delta-8 tetrahydrocannabinol product impurities. Molecules 2022;27(20):6924.
- Vanegas SO, Reck AM, Rodriguez CE, et al. Assessment of dependence potential and abuse liability of ?(8)-tetrahydrocannabinol in mice. Drug Alcohol Depend 2022;240:109640.
- Leas EC, Harati RM, Satybaldiyeva N, et al. Self-reported adverse events associated with ?(8)-Tetrahydrocannabinol (Delta-8-THC) Use. J Cannabis Res 2023;5(1):15.
- Radwan MM, Wanas AS, Gul W, Ibrahim EA, ElSohly MA. Isolation and Characterization of Impurities in Commercially Marketed ?8-THC Products. J Nat Prod. 2023;86(4):822-829.
- Simon TA, Simon JH, Heaning EG, Gomez-Caminero A, Marcu JP. Delta-8, a Cannabis-Derived Tetrahydrocannabinol Isomer: Evaluating Case Report Data in the Food and Drug Administration Adverse Event Reporting System (FAERS) Database. Drug Healthc Patient Saf 2023;15:25-38.
- Tagen M, Klumpers LE, Peshkovsky A. Pharmacokinetics of Two Nanoemulsion Formulations of ?(8)-Tetrahydrocannabinol in Rats. AAPS PharmSciTech 2023;24(8):239.
- Bradley EK, Hoots BE, Bradley ES, Roehler DR. Unintentional ingestion of putative delta-8 tetrahydrocannabinol by two youth requiring critical care: a case report. J Cannabis Res 2023;5(1):9.
- Shaker K, Nillas A, Ellison R, et al. Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients. J Med Toxicol 2023;19(2):190-195.
- Miller CR, Burk BG, Fargason RE, Birur B. Delta-8-THC association with psychosis: A case report with literature review. Front Psychiatry 2023;14:1103123.
- Moore CF, Weerts EM, Kulpa J, et al. Pharmacokinetics of Oral Minor Cannabinoids in Blood and Brain. Cannabis Cannabinoid Res 2023;8(S1):S51-S61.
- US Food and Drug Administration (FDA). FDA, FTC Continue Joint Effort to Protect Consumers Against Companies Illegally Selling Copycat Delta-8 THC Food Products. July 16, 2024. Available at: https://www.fda.gov/news-events/press-announcements/fda-ftc-continue-joint-effort-protect-consumers-against-companies-illegally-selling-copycat-delta-8. Accessed July 22, 2024.
