Chokeberry
OTHER NAME(S): Aronia Berry, Black Apple Berry, Black Chokeberry, Purple Chokeberry, Red Chokeberry, Wild Chokeberry, Aronia arbutifolia, Aronia melanocarpa, Aronia nigra, Aronia prunifolia, Aronia Negra, Baie d'aronia
Overview
Chokeberry is a fruit that comes from the aronia shrub. It's eaten as food in Russia and parts of Eastern Europe. It's also used in traditional medicines.
Chokeberry is high in antioxidants, fiber, and other chemicals. These chemicals might help protect the heart and blood vessels and reduce swelling and blood sugar levels.
People use chokeberry for heart disease, athletic performance, cancer, diabetes, high cholesterol, high blood pressure, and many other conditions, but there's no good scientific evidence to support these uses.
Uses
Possibly Ineffective for
- Heart disease. Taking chokeberry by mouth doesn't lower blood pressure, cholesterol levels, or blood sugar levels in people with or at risk for heart disease.
There is interest in using chokeberry for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When taken by mouth Chokeberry extract and chokeberry juice are possibly safe for most adults when used short-term. It's usually well-tolerated. Side effects might include constipation, diarrhea, or nausea.
Precautions
When taken by mouth Chokeberry extract and chokeberry juice are possibly safe for most adults when used short-term. It's usually well-tolerated. Side effects might include constipation, diarrhea, or nausea.
Pregnancy and breast-feeding: There isn't enough reliable information to know if chokeberry is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
Moderate Interaction
Be cautious with this combination
- Trabectedin (Yondelis) interacts with ChokeberryTrabectedin is changed and broken down by the liver. Chokeberry might decrease how quickly the liver breaks down trabectedin. Taking chokeberry along with trabectedin might increase the effects and side effects of trabectedin.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with ChokeberryChokeberry might slow blood clotting. Taking chokeberry along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
- Medications for diabetes (Antidiabetes drugs) interacts with ChokeberryChokeberry might lower blood sugar levels. Taking chokeberry along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with ChokeberrySome medications are changed and broken down by the liver. Chokeberry might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Dosing
Chokeberry juice has most often been consumed by adults at amounts of 200-500 mL daily for up to 12 weeks. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.
References
- Buckland G, Mayén AL, Agudo A, Travier N, Navarro C, Huerta JM, Chirlaque MD, Barricarte A, Ardanaz E, Moreno-Iribas C, Marin P, Quirós JR, Redondo ML, Amiano P, Dorronsoro M, Arriola L, Molina E, Sanchez MJ, Gonzalez CA. Olive oil intake and mortality within the Spanish population (EPIC-Spain). Am J Clin Nutr. 2012 Jul;96(1):142-9.
- Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food. 2010 Apr;13(2):255-69.
- Kulling SE, Rawel HM. Chokeberry (Aronia melanocarpa) - A review on the characteristic components and potential health effects. Planta Med. 2008 Oct;74(13):1625-34.
- Valcheva-Kuzmanova SV, Belcheva A. Current knowledge of Aronia melanocarpa as a medicinal plant. Folia Med (Plovdiv). 2006;48(2):11-7.
- Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J. Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monit. 2010 Jan;16(1):CR28-34.
- Sikora J, Broncel M, Markowicz M, Chalubinski M, Wojdan K, Mikiciuk-Olasik E. Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. Eur J Nutr. 2012 Aug;51(5):549-56.
- Mulero J, Bernabé J, Cerdá B, García-Viguera C, Moreno DA, Albaladejo MD, Avilés F, Parra S, Abellán J, Zafrilla P. Variations on cardiovascular risk factors in metabolic syndrome after consume of a citrus-based juice. Clin Nutr. 2012 Jun;31(3):372-7.
- 92366 Sonoda K, Aoi W, Iwata T, Li Y. Anthocyanin-rich Aronia melanocarpa extract improves body temperature maintenance in healthy women with a cold constitution. Springerplus. 2013 Nov 21;2:626.
- Handeland M, Grude N, Torp T, Slimestad R. Black chokeberry juice (Aronia melanocarpa) reduces incidences of urinary tract infection among nursing home residents in the long term--a pilot study. Nutr Res. 2014 Jun;34(6):518-25.
- Kardum N, Petrovic-Oggiano G, Takic M, Glibetic N, Zec M, Debeljak-Martacic J, Konic-Ristic A. Effects of glucomannan-enriched, aronia juice-based supplement on cellular antioxidant enzymes and membrane lipid status in subjects with abdominal obesity. ScientificWorldJournal. 2014;2014:869250.
- Poreba R, Skoczynska A, Gac P, Poreba M, Jedrychowska I, Affelska-Jercha A, Turczyn B, Wojakowska A, Oszmianski J, Andrzejak R. Drinking of chokeberry juice from the ecological farm Dzieciolowo and distensibility of brachial artery in men with mild hypercholesterolemia. Ann Agric Environ Med. 2009;16(2):305-8.
- Tjelle TE, Holtung L, Bøhn SK, Aaby K, Thoresen M, Wiik SÅ, Paur I, Karlsen AS, Retterstøl K, Iversen PO, Blomhoff R. Polyphenol-rich juices reduce blood pressure measures in a randomised controlled trial in high normal and hypertensive volunteers. Br J Nutr. 2015 Oct 14;114(7):1054-63.
- Kardum N, Milovanovic B, Savikin K, Zdunic G, Mutavdzin S, Gligorijevic T, Spasic S. Beneficial Effects of Polyphenol-Rich Chokeberry Juice Consumption on Blood Pressure Level and Lipid Status in Hypertensive Subjects. J Med Food. 2015 Nov;18(11):1231-8.
- Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM. Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv). 2002;44(3):20-3.
- Naruszewicz M, Laniewska I, Millo B, Dluzniewski M. Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infraction (MI). Atherosclerosis. 2007 Oct;194(2):e179-84.
- Savikin K, Menkovic N, Zdunic G, Pljevljakusic D, Spasic S, Kardum N, Konic-Ristic A. Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite. J Med Food. 2014 May;17(5):582-7.
- Chrubasik C, Li G, Chrubasik S. The clinical effectiveness of chokeberry: a systematic review. Phytother Res. 2010 Aug;24(8):1107-14.
- Bräunlich M, Christensen H, Johannesen S, Slimestad R, Wangensteen H, Malterud KE, Barsett H. In vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents. Planta Med. 2013 Jan;79(2):137-41.
- Strippoli S, Lorusso V, Albano A, Guida M. Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin. BMC Complement Altern Med. 2013 Jul 30;13:199.
- Ryszawa N, Kawczynska-Drózdz A, Pryjma J, Czesnikiewicz-Guzik M, Adamek-Guzik T, Naruszewicz M, Korbut R, Guzik TJ. Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. J Physiol Pharmacol. 2006 Dec;57(4):611-26.
- Denev P, Kratchanova M, Ciz M, Lojek A, Vasicek O, Nedelcheva P, Blazheva D, Toshkova R, Gardeva E, Yossifova L, Hyrsl P, Vojtek L. Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health. Food Chem. 2014 Aug 15;157:37-44.
- Abdullah Thani NA, Sallis B, Nuttall R, Schubert FR, Ahsan M, Davies D, Purewal S, Cooper A, Rooprai HK. Induction of apoptosis and reduction of MMP gene expression in the U373 cell line by polyphenolics in Aronia melanocarpa and by curcumin. Oncol Rep. 2012 Oct;28(4):1435-42.
- Jurgonski A, Juskiewicz J, Zdunczyk Z. Ingestion of black chokeberry fruit extract leads to intestinal and systemic changes in a rat model of prediabetes and hyperlipidemia. Plant Foods Hum Nutr. 2008 Dec;63(4):176-82.
- Qin B, Anderson RA. An extract of chokeberry attenuates weight gain and modulates insulin, adipogenic and inflammatory signalling pathways in epididymal adipose tissue of rats fed a fructose-rich diet. Br J Nutr. 2012 Aug;108(4):581-7.
- Takahashi A, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats. J Oleo Sci. 2015;64(12):1243-50.
- Kowalczyk E, Fijalkowski P, Kura M, Krzesinski P, Blaszczyk J, Kowalski J, Smigielski J, Rutkowski M, Kopff M. [The influence of anthocyanins from Aronia melanocarpa on selected parameters of oxidative stress and microelements contents in men with hypercholesterolemia]. Pol Merkur Lekarski. 2005 Nov;19(113):651-3.
- Pilaczynska-Szczesniak L, Skarpanska-Steinborn A, Deskur E, Basta P, Horoszkiewicz-Hassan M. The influence of chokeberry juice supplementation on the reduction of oxidative stress resulting from an incremental rowing ergometer exercise. Int J Sport Nutr Exerc Metab. 2005 Feb;15(1):48-58.
- Pawlowicz P, Stachowiak G, Bielak A, Wilczynski J. [Administration of natural anthocyanins derived from chokeberry (aronia melanocarpa) extract in the treatment of oligospermia in males with enhanced autoantibodies to oxidized low density lipoproteins (oLAB). The impact on fructose levels]. Ginekol Pol. 2001 Dec;72(12):983-8.
- García-Flores LA, Medina S, Cejuela-Anta R, Martínez-Sanz JM, Abellán Á, Genieser HG, Ferreres F, Gil-Izquierdo Á. DNA catabolites in triathletes: effects of supplementation with an aronia-citrus juice (polyphenols-rich juice). Food Funct. 2016 Apr;7(4):2084-93.
- Skarpanska-Stejnborn A, Basta P, Sadowska J, Pilaczynska-Szczesniak L. Effect of supplementation with chokeberry juice on the inflammatory status and markers of iron metabolism in rowers. J Int Soc Sports Nutr. 2014 Oct 1;11(1):48.
- Kedzierska M, Olas B, Wachowicz B, Glowacki R, Bald E, Czernek U, Szydlowska-Pazera K, Potemski P, Piekarski J, Jeziorski A. Effects of the commercial extract of aronia on oxidative stress in blood platelets isolated from breast cancer patients after the surgery and various phases of the chemotherapy. Fitoterapia. 2012 Mar;83(2):310-7.
- Park S, Kim JI, Lee I, Lee S, Hwang MW, Bae JY, Heo J, Kim D, Han SZ, Park MS. Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses. Biochem Biophys Res Commun. 2013 Oct 11;440(1):14-9.
- Zapolska-Downar D, Bryk D, Malecki M, Hajdukiewicz K, Sitkiewicz D. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur J Nutr. 2012 Aug;51(5):563-72.
- Kim B, Ku CS, Pham TX, Park Y, Martin DA, Xie L, Taheri R, Lee J, Bolling BW. Aronia melanocarpa (chokeberry) polyphenol-rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice. Nutr Res. 2013 May;33(5):406-13.
- Duchnowicz P, Nowicka A, Koter-Michalak M, Broncel M. In vivo influence of extract from Aronia melanocarpa on the erythrocyte membranes in patients with hypercholesterolemia. Med Sci Monit. 2012 Sep;18(9):CR569-74.
- Sikora J, Broncel M, Mikiciuk-Olasik E. Aronia melanocarpa Elliot reduces the activity of angiotensin i-converting enzyme-in vitro and ex vivo studies. Oxid Med Cell Longev. 2014;2014:739721.
- Valcheva-Kuzmanova SV, Eftimov MT, Tashev RE, Belcheva IP, Belcheva SP. Memory effects of Aronia melanocarpa fruit juice in a passive avoidance test in rats. Folia Med (Plovdiv). 2014 Jul-Sep;56(3):199-203.
- Kim NY, Lee HY. Enhancement of Cognitive Functions by Aronia melanocarpa Elliot Through an Intermittent Ultrasonication Extraction Process. J Med Food. 2016 Mar;19(3):245-52.
- Lee HY, Weon JB, Jung YS, Kim NY, Kim MK, Ma CJ. Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice. Evid Based Complement Alternat Med. 2016;2016:6145926.
- Kim JH, Auger C, Kurita I, Anselm E, Rivoarilala LO, Lee HJ, Lee KW, Schini-Kerth VB. Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase. Nitric Oxide. 2013 Nov 30;35:54-64.
- Varela CE, Fromentin E, Roller M, Villarreal F, Ramirez-Sanchez I. Effects of a natural extract of Aronia Melanocarpa berry on endothelial cell nitric oxide production. J Food Biochem. 2016 Aug;40(4):404-410.
- Goh AR, Youn GS, Yoo KY, Won MH, Han SZ, Lim SS, Lee KW, Choi SY, Park J. Aronia melanocarpa Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice. J Med Food. 2016 Jul;19(7):654-62.
- Ohgami K, Ilieva I, Shiratori K, Koyama Y, Jin XH, Yoshida K, Kase S, Kitaichi N, Suzuki Y, Tanaka T, Ohno S. Anti-inflammatory effects of aronia extract on rat endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 2005 Jan;46(1):275-81.
- Yaneva MP, Botushanova AD, Grigorov LA, Kokov JL, Todorova EP, Krachanova MG. Evaluation of the immunomodulatory activity of Aronia in combination with apple pectin in patients with breast cancer undergoing postoperative radiation therapy. Folia Med (Plovdiv). 2002;44(1-2):22-5.
- Taira T, Yamaguchi S, Takahashi A, Okazaki Y, Yamaguchi A, Sakaguchi H, Chiji H. Dietary polyphenols increase fecal mucin and immunoglobulin A and ameliorate the disturbance in gut microbiota caused by a high fat diet. J Clin Biochem Nutr. 2015 Nov;57(3):212-6.
- Wiczkowski W, Romaszko E, Piskula MK. Bioavailability of cyanidin glycosides from natural chokeberry (Aronia melanocarpa) juice with dietary-relevant dose of anthocyanins in humans. J Agric Food Chem. 2010 Dec 8;58(23):12130-6.
- Xie L, Lee SG, Vance TM, Wang Y, Kim B, Lee JY, Chun OK, Bolling BW. Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract. Food Chem. 2016 Nov 15;211:860-8.
- Kay CD, Mazza G, Holub BJ, Wang J. Anthocyanin metabolites in human urine and serum. Br J Nutr. 2004 Jun;91(6):933-42.
- Kay CD, Mazza GJ, Holub BJ. Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr. 2005 Nov;135(11):2582-8.
- Loo BM, Erlund I, Koli R, et al. Consumption of chokeberry (Aronia mitschurinii) products modestly lowered blood pressure and reduced low-grade inflammation in patients with mildly elevated blood pressure. Nutr Res. 2016;36(11):1222-1230.
- Pokimica B, García-Conesa MT, Zec M, et al. Chokeberry juice containing polyphenols does not affect cholesterol or blood pressure but modifies the composition of plasma phospholipids fatty acids in individuals at cardiovascular risk. Nutrients. 2019;11(4):850.
- Nowak D, Goslinski M, Wesolowska A, Berenda K, Poplawski C. Effects of acute consumption of noni and chokeberry juices vs. energy drinks on blood pressure, heart rate, and blood glucose in young adults. Evid Based Complement Alternat Med. 2019;2019:6076751.
- Rahmani J, Clark C, Kord Varkaneh H, et al. The effect of Aronia consumption on lipid profile, blood pressure, and biomarkers of inflammation: a systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(8):1981-90.
- Ahles S, Stevens YR, Joris PJ, et al. The effect of long-term Aronia melanocarpa extract supplementation on cognitive performance, mood, and vascular function: a randomized controlled trial in healthy, middle-aged individuals. Nutrients 2020;12(8):2475. doi: 10.3390/nu12082475.
- Cikiriz N, Milosavljevic I, Jakovljevic B, et al. The influences of chokeberry extract supplementation on redox status and body composition in handball players during competition phase. Can J Physiol Pharmacol 2021;99(1):42-47.
- Tasic N, Jakovljevic VLJ, Mitrovic M, et al. Black chokeberry Aronia melanocarpa extract reduces blood pressure, glycemia and lipid profile in patients with metabolic syndrome: a prospective controlled trial. Mol Cell Biochem 2021 Mar 5. doi: 10.1007/s11010-021-04106-4.
- Stankiewicz B, Cieslicka M, Kujawski S, et al. Effects of antioxidant supplementation on oxidative stress balance in young footballers- a randomized double-blind trial. J Int Soc Sports Nutr 2021;18(1):44.
- Stankiewicz B, Cieslicka M, Mieszkowski J, et al. Effect of supplementation with black chokeberry (Aronia melanocarpa) extract on inflammatory status and selected markers of iron metabolism in young football players: a randomized double-blind trial. Nutrients 2023;15(4):975.
- Petrovic M, Kesic L, Šavikin K, et al. Can the chokeberry juice be used as additional therapy for burning mouth syndrome in menopausal women?. Health Care Women Int 2021.
- Milutinovic M, Velickovic Radovanovic R, Savikin K, et al. Chokeberry juice supplementation in type 2 diabetic patients - impact on health status. J Appl Biomed 2019;17(4):218-224.
- Lackner S, Sconocchia T, Ziegler T, et al. Immunomodulatory effects of aronia juice polyphenols-results of a randomized placebo-controlled human intervention study and cell culture experiments. Antioxidants (Basel) 2022;11(7):1283.
- Milosavljevic I, Jakovljevic V, Petrovic D, et al. Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia. Mol Cell Biochem 2021;476(11):4167-75.
- Habanova M, Holovicova M, Scepankova H, et al. Modulation of lipid profile and lipoprotein subfractions in overweight/obese women at risk of cardiovascular diseases through the consumption of apple/berry juice. Antioxidants (Basel) 2022;11(11):2239.
- Chung JW, Kim JE, Nam YE, et al. Eight-week supplementation of Aronia berry extract promoted the glutathione defence system against acute aerobic exercise-induced oxidative load immediately and 30?min post-exercise in healthy adults: a double-blind, randomised controlled trial. J Hum Nutr Diet 2023.
