Castor Bean
OTHER NAME(S): African Coffee Tree, Arandi, Bi Ma Zi, Bofareira, Castorbean, Erand, Eranda, Gandharva Hasta, Graine de Ricin, Huile de Ricin, Huile de Ricin Végétale, Mexico Weed, Palma Christi, Ricin, Ricin Commun, Ricin Sanguin, Ricine, Tangantangan Oil Plant, Wonder Tree, Ricinus communis, Ricinus sanguines, Castor Oil, Castor Bean, Castor seed oil, Ricino, Graine de ricin
Overview
Castor oil is made from the beans (seeds) of the castor plant (Ricinus communis). Its taste is initially bland, then becomes bitter and unpleasant.
Castor oil has laxative and anti-inflammatory effects. It also might induce labor. It's sometimes flavored with cinnamon, peppermint, or other flavorings to mask its unpleasant taste.
People use castor oil for constipation, dry eye, childbirth, and to empty the colon before a colonoscopy. It is also used for osteoarthritis, rheumatoid arthritis, and many other conditions, but there is no good scientific evidence to support most of these uses.
The outer coat (hull) of the castor seed contains a deadly poison called ricin. The hull must be removed before use. Ricin has been tested as a chemical warfare agent. Weapons-grade ricin is purified and produced in particles that are so small they can be breathed in.
Uses
Possibly Effective for
- Emptying the colon before a colonoscopy. Taking castor oil by mouth might help empty the colon. But it's not clear if it works as well as other bowel preparations, such as sodium phosphate. Castor oil is not recommended for people who are preparing for a colonoscopy.
- Constipation. Taking castor oil by mouth seems to help relieve constipation.
- Dry eye. Using eye drops containing castor oil might reduce symptoms in people with dry eyes.
- Childbirth. Taking castor oil by mouth might start labor in patients who are at or past their delivery date but have not gone into labor.
There is interest in using castor bean for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Side Effects
When applied into the eye: Castor oil eye drops are possibly safe when used for up to 30 days.
When taken by mouth: Castor oil is likely safe when taken as a single dose of up to 60 mL. Side effects might include stomach discomfort, cramping, nausea, and dizziness. Castor oil is possibly unsafe when taken long-term or in large doses. It might cause fluid and potassium loss.
Castor seeds that have had the outer coat removed (hulled) are possibly safe when taken as a single dose. But consuming the whole castor seed is unsafe. The hull contains a deadly poison called ricin. Chewing as few as 1-6 whole seeds can kill an adult.
Precautions
When applied into the eye: Castor oil eye drops are possibly safe when used for up to 30 days.
When taken by mouth: Castor oil is likely safe when taken as a single dose of up to 60 mL. Side effects might include stomach discomfort, cramping, nausea, and dizziness. Castor oil is possibly unsafe when taken long-term or in large doses. It might cause fluid and potassium loss.
Castor seeds that have had the outer coat removed (hulled) are possibly safe when taken as a single dose. But consuming the whole castor seed is unsafe. The hull contains a deadly poison called ricin. Chewing as few as 1-6 whole seeds can kill an adult.
Pregnancy: Castor oil is possibly safe when taken by mouth during pregnancy when at or beyond the pregnancy due date. But castor oil should not be used for this purpose without the supervision of a healthcare provider. Castor oil is likely unsafe when taken before the pregnancy due date is reached. It might bring on labor too early. Taking whole castor seeds by mouth is unsafe. There isn't enough reliable information to know if hulled castor seeds are safe or what the side effects might be. Stay on the safe side and avoid use.
Breast-feeding: There isn't enough reliable information to know if castor oil is safe to use when breast-feeding. Stay on the safe side and avoid use.
Children: Castor oil is possibly safe when taken by mouth in appropriate doses, short-term. But castor oil is possibly unsafe when taken by mouth for more than one week or at doses greater than 1-15 mL daily, depending on age. It can cause a chemical imbalance in the body. Taking whole castor seeds by mouth is unsafe.
Intestinal problems: Don't use castor oil if you have a blocked intestine, unexplained stomach pain, or problems with your bile ducts or gall bladder.
Interactions
Moderate Interaction
Be cautious with this combination
- Water pills (Diuretic drugs) interacts with Castor BeanCastor oil is a laxative. Some laxatives can cause diarrhea and decrease potassium levels. "Water pills" can also decrease potassium levels. Taking castor oil along with "water pills" might make potassium levels drop too low.
Dosing
Castor oil has most often been used by adults as a single dose of 5-120 mL by mouth. Speak with a healthcare provider to find out what dose might be best for a specific condition.
References
- Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- Tyler VE. Herbs of Choice. Binghamton, NY: Pharmaceutical Products Press, 1994.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- United States Pharmacopeial Convention, Inc., ed. Drug Information for the Health Care Professional. 19th ed. Englewood, CO: Micromedex Inc., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- McFarlin BL, Gibson MH, O'Rear J, Harman P. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J Nurse Midwifery 1999;44:205-16.
- Steingrub JS, Lopez T, Teres D, et al. Amniotic fluid embolism associated with castor oil ingestion. Crit Care Med 1988;16:642-3.
- Melia AT, Koss-Twardy SG, Zhi J. The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers. J Clin Pharmacol 1996;36:647-53.
- Vehmeyer K, Hajito T, Hostanska K, et al. Lectin-induced increase in clonogenic growth of haematopoietic progenitor cells. Eur J Haematol 1998;60:16-20.
- Challoner KR, McCarron MM. Castor bean intoxication. Ann Emerg Med 1990;19:1177-83.
- Palatnick W, Tenenbein M. Hepatotoxicity from castor bean ingestion in a child. J Toxicol Clin Toxicol 2000;38:67-9.
- Das SC, Isichei CO, Okwuasaba FK, et al. Chemical, pathological and toxicological studies of the effects of RICOM-1013-J of Ricinus communis var minor on women volunteers and rodents. Phytother Res 2000;14:15-9.
- Isichei CO, Das SC, Ogunkeye OO, et al. Preliminary clinical investigation of the contraceptive efficacy and chemical pathological effects of RICOM-1013-J of Ricinus communis var minor on women volunteers. Phytother Res 2000;14:40-2.
- Garry D, Figueroa R, Guillaume J, Cucco V. Use of castor oil in pregnancies at term. Altern Ther Health Med 2000;6:77-9.
- Audi J, Belson M, Patel M, et al. Ricin poisoning: a comprehensive review. JAMA 2005;294:2342-51.
- Allaire AD, Moos MK, Wells SR. Complementary and alternative medicine in pregnancy: A survey of North Carolina certified nurse-midwives. Obstet Gynecol 2000;95:19-23.
- Novetsky, G. J., Turner, D. A., Ali, A., Raynor, W. J., Jr., and Fordham, E. W. Cleansing the colon in gallium-67 scintigraphy: a prospective comparison of regimens. AJR Am J Roentgenol. 1981;137(5):979-981.
- Chen, C. C., Ng, W. W., Chang, F. Y., and Lee, S. D. Magnesium citrate-bisacodyl regimen proves better than castor oil for colonoscopic preparation. J.Gastroenterol.Hepatol. 1999;14(12):1219-1222.
- Sall, K., Stevenson, O. D., Mundorf, T. K., and Reis, B. L. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 2000;107(4):631-639.
- Stevenson, D., Tauber, J., and Reis, B. L. Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial. The Cyclosporin A Phase 2 Study Group. Ophthalmology 2000;107(5):967-974.
- Hsieh, J. F., Que, J., Tsai, S. C., Cheng, K. Y., Lin, W. Y., and Wang, S. J. Does bowel preparation improve the quality of abdominal gallium scintigraphy? Nucl.Med Commun. 2000;21(11):1033-1036.
- Vieira, C., Evangelista, S., Cirillo, R., Lippi, A., Maggi, C. A., and Manzini, S. Effect of ricinoleic acid in acute and subchronic experimental models of inflammation. Mediators.Inflamm. 2000;9(5):223-228.
- Zhang, K. E., Wu, E., Patick, A. K., Kerr, B., Zorbas, M., Lankford, A., Kobayashi, T., Maeda, Y., Shetty, B., and Webber, S. Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities. Antimicrob.Agents Chemother. 2001;45(4):1086-1093.
- Goto, E., Shimazaki, J., Monden, Y., Takano, Y., Yagi, Y., Shimmura, S., and Tsubota, K. Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction. Ophthalmology 2002;109(11):2030-2035.
- Pearce, E. I., Tomlinson, A., Blades, K. J., Falkenberg, H. K., Lindsay, B., and Wilson, C. G. Effect of an oil and water emulsion on tear evaporation rate. Adv.Exp.Med Biol. 2002;506(Pt A):419-423.
- Di Pascuale, M. A., Goto, E., and Tseng, S. C. Sequential changes of lipid tear film after the instillation of a single drop of a new emulsion eye drop in dry eye patients. Ophthalmology 2004;111(4):783-791.
- Yang, H. C., Sheu, M. H., Wang, J. H., and Chang, C. Y. Bowel preparation of outpatients for intravenous urography: efficacy of castor oil versus bisacodyl. Kaohsiung.J Med Sci 2005;21(4):153-158.
- Beitz, J. M. Heparin-induced thrombocytopenia syndrome bullous lesions treated with trypsin-balsam of peru-castor oil ointment: a case study. Ostomy.Wound.Manage. 2005;51(6):52-58.
- Micha, J. P., Goldstein, B. H., Birk, C. L., Rettenmaier, M. A., and Brown, J. V., III. Abraxane in the treatment of ovarian cancer: the absence of hypersensitivity reactions. Gynecol.Oncol. 2006;100(2):437-438.
- Vitetta, E. S., Smallshaw, J. E., Coleman, E., Jafri, H., Foster, C., Munford, R., and Schindler, J. A pilot clinical trial of a recombinant ricin vaccine in normal humans. Proc.Natl.Acad.Sci U.S.A 2-14-2006;103(7):2268-2273.
- Azhari, S., Pirdadeh, S., Lotfalizadeh, M., and Shakeri, M. T. Evaluation of the effect of castor oil on initiating labor in term pregnancy. Saudi.Med J 2006;27(7):1011-1014.
- Khanal, S., Tomlinson, A., Pearce, E. I., and Simmons, P. A. Effect of an oil-in-water emulsion on the tear physiology of patients with mild to moderate dry eye. Cornea 2007;26(2):175-181.
- Okwuasaba, F. K., Osunkwo, U. A., Ekwenchi, M. M., Ekpenyong, K. I., Onwukeme, K. E., Olayinka, A. O., Uguru, M. O., and Das, S. C. Anticonceptive and estrogenic effects of a seed extract of Ricinus communis var. minor. J Ethnopharmacol. 1991;34(2-3):141-145.
- Final report on the safety assessment of Ricinus Communis (Castor) Seed Oil, Hydrogenated Castor Oil, Glyceryl Ricinoleate, Glyceryl Ricinoleate SE, Ricinoleic Acid, Potassium Ricinoleate, Sodium Ricinoleate, Zinc Ricinoleate, Cetyl Ricinoleate, Ethyl Ricinoleate, Glycol Ricinoleate, Isopropyl Ricinoleate, Methyl Ricinoleate, and Octyldodecyl Ricinoleate. Int J Toxicol. 2007;26 Suppl 3:31-77.
- Fromtling, R. A. Overview of medically important antifungal azole derivatives. Clin.Microbiol.Rev. 1988;1(2):187-217.
- Roberge-Wade, A. P., Hosking, D. H., MacEwan, D. W., and Ramsey, E. W. The excretory urogram bowel preparation--is it necessary? J Urol. 1988;140(6):1473-1474.
- Kris, M. G., Gralla, R. J., Clark, R. A., Tyson, L. B., and Groshen, S. Control of chemotherapy-induced diarrhea with the synthetic enkephalin BW942C: a randomized trial with placebo in patients receiving cisplatin. J Clin.Oncol. 1988;6(4):663-668.
- Mitri, F., Hofmeyr, G. J., and van Gelderen, C. J. Meconium during labour--self-medication and other associations. S.Afr.Med J 4-4-1987;71(7):431-433.
- Strates, B. S. and Hofmann, L. M. A randomized study of two preparations for large bowel radiology. Pharmatherapeutica 1987;5(1):57-61.
- Ryan, J., Leighton, J., Kirksey, D., and McMahon, G. Evaluation of an enkephalin analog in men with castor oil-induced diarrhea. Clin.Pharmacol.Ther. 1986;39(1):40-42.
- Dodds, W. J., Scanlon, G. T., Shaw, D. K., Stewart, E. T., Youker, J. E., and Metter, G. E. An evaluation of colon cleansing regimens. AJR Am.J Roentgenol. 1977;128(1):57-59.
- Present, A. J., Jansson, B., Burhenne, H. J., Dodd, G. D., Goldberg, H. I., Goldstein, H. M., Miller, R. E., Nelson, J. A., and Stewart, E. T. Evaluation of 12 colon-cleansing regimens with single-contrast barium enema. AJR Am.J Roentgenol. 1982;139(5):855-860.
- Scarpa, A. and Guerci, A. Various uses of the castor oil plant (Ricinus communis L.). A review. J.Ethnopharmacol. 1982;5(2):117-137.
- Luderer, J. R., Demers, L. M., Nomides, C. T., and Hayes, A. H., Jr. Mechanism of action of castor oil: a biochemical link to the prostaglandins. Adv.Prostaglandin Thromboxane Res. 1980;8:1633-1635.
- Sugar, A. M., Salibian, M., and Goldani, L. Z. Saperconazole therapy of murine disseminated candidiasis: efficacy and interactions with amphotericin B. Antimicrob.Agents Chemother. 1994;38(2):371-373.
- Kolts, B. E., Lyles, W. E., Achem, S. R., Burton, L., Geller, A. J., and MacMath, T. A comparison of the effectiveness and patient tolerance of oral sodium phosphate, castor oil, and standard electrolyte lavage for colonoscopy or sigmoidoscopy preparation. Am.J.Gastroenterol. 1993;88(8):1218-1223.
- Marmion, L. C., Desser, K. B., Lilly, R. B., and Stevens, D. A. Reversible thrombocytosis and anemia due to miconazole therapy. Antimicrob.Agents Chemother. 1976;10(3):447-449.
- Al-Mamun MA, Akter Z, Uddin MJ, et al. Characterization and evaluation of antibacterial and antiproliferative activities of crude protein extracts isolated from the seed of Ricinus communis in Bangladesh. BMC Complement Altern Med. 2016;16:211.
- Al-Tamimi FA, Hegazi AE. A case of castor bean poisoning. Sultan Qaboos Univ Med J 2008;8(1):83-7.
- Doshi KA, Acharya R, Shukla VJ, et al. Phytochemical evaluation of the wild and cultivated varieties of Eranda Mula (Roots of Ricinus communis Linn.). Ayu 2013;34(2):200-3.
- Ferguson TS. Castor bean ingestion and ricin toxicity in a case of attempted suicide. West Indian Med J 2011;60(5):596.
- Kamath JV, Rana AC, Chowdhury AR. Pro-healing effect of Cinnamomum zeylanicum bark. Phytother Res 2003;17(8):970-2.
- Nath S, Dutta Choudhury M, Roychoudhury S, et al. Male contraceptive efficacy of Ricinus communis L. extract. J Ethnopharmacol 2013;149(1):328-34.
- Pinelli LA, Montandon AA, Corbi SC, et al. Ricinus communis treatment of denture stomatitis in institutionalised elderly. J Oral Rehabil 2013;40(5):375-80.
- Taur DJ, Waghmare MG, Bandal RS, et al. Antinociceptive activity of Ricinus communis L. leaves. Asian Pac J Trop Biomed 2011;1(2):139-41.
- Thornton SL, Darracq M, Lo J, et al. Castor bean seed ingestions: a state-wide poison control system's experience. Clin Toxicol (Phila) 2014;52(4):265-8.
- Wachira SW, Omar S, Jacob JW, et al. Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae. Parasit Vectors 2014;7:312.
- Worbs S, Köhler K, Pauly D, et al. Ricinus communis intoxications in human and veterinary medicine-a summary of real cases. Toxins (Basel) 2011;3(10):1332-72.
- Zarai Z, Ben Chobba I, Ben Mansour R, et al. Essential oil of the leaves of Ricinus communis L.: in vitro cytotoxicity and antimicrobial properties. Lipids Health Dis 2012;11:102.
- Verougstraete N, Helsloot D, Deprez C, Heylen O, Casier I, Croes K. Lethal Injection of a Castor Bean Extract: Ricinine Quantification as a Marker for Ricin Exposure Using a Validated LC-MS/MS Method. J Anal Toxicol. 2019;43(3):e1-e5.
- ASGE Standards of Practice Committee. Guideline: Bowel preparation before colonoscopy. Gastrointestinal Endoscopy. 2015;81(4):781-94.
- Sánchez-Herrero A, Mateos-Mayo A, Rodríguez-Lomba E, et al. Allergic contact cheilitis in an adolescent to Ricinus communis seed oil (castor oil) in a lip balm. Contact Dermatitis. 2018;79(3):176-178.
- Adeoye SWA, Mayowa MF, Akano FM, Sultan AO. Methanolic Extract of Ricinus Communis ameliorated cardiovascular dysfunction in dichlorvos-exposed rats. Niger J Physiol Sci. 2023;38(2):231-239. Published 2023 Dec 31.
