Calamus
OTHER NAME(S): Acore Calame, Acore Odorant, Acore Olorant, Acore Roseau, Acorus Roseau, Aruna, Bach, Bajai, Baje, Belle-Angélique, Bhutanashini, Calamo Aromatic, Calamus Root, Cinnamon Sedge, Flag Root, Flagroot, Gladdon, Golomi, Grass-Leaf Sweetflag, Grass Myrtle, Kalmus, Myrtle Flag, Myrtle Sedge, Sadgrantha, Shadgrandha, Shatvarvika, Shi Chang Pu, Sweet Calomel, Sweet Calamus, Sweet Cane, Sweet Cinnamon, Sweet Flag, Sweet Grass, Sweet Myrtle, Sweet Root, Sweet Rush, Sweet Sedge, Ugragandha, Vach, Vacha, Vachha, Vadaja, Vaj, Vasa, Vash, Vashambu, Vayambu, Vayambur, Vekhand, Waan-Nam, Acorus calamus, Acorus americanus, Acorus asiaticus, Acorus gramineus, Acorus tatarinowii, Acorus terrestris, Acorus sp., Calmus, Cálamo, Acore odorant
Overview
Calamus (Acorus calamus) is a grass-like plant found in swamps and near rivers. It has a long history of use in Ayurvedic and traditional Chinese medicine.
There are four different types of calamus. Some contain a cancer-causing chemical called beta-asarone. The North American and European varieties contain little to no beta-asarone, but others contain up to 96%. It also contains chemicals that might reduce pain and help fight infections.
People use calamus for asthma, cancer, depression, diabetes, headache, stomach ulcers, and many other conditions, but there is no good scientific evidence to support these uses. Using calamus can also be unsafe.
The US FDA banned calamus in 1968 due to some species containing the cancer-causing chemical beta-asarone.
Uses
We currently have no information for Calamus overview.
Side Effects
When taken by mouth: Calamus is likely unsafe. The US FDA prohibits using calamus in food products because some species contain a cancer-causing chemical called beta-asarone. The amount of beta-asarone in calamus species can vary widely. In addition to cancer, side effects might include nausea and vomiting.
When applied to the skin: There isn't enough reliable information to know if calamus is safe or what the side effects might be.
Precautions
When taken by mouth: Calamus is likely unsafe. The US FDA prohibits using calamus in food products because some species contain a cancer-causing chemical called beta-asarone. The amount of beta-asarone in calamus species can vary widely. In addition to cancer, side effects might include nausea and vomiting.
When applied to the skin: There isn't enough reliable information to know if calamus is safe or what the side effects might be.
Pregnancy and breast-feeding: Calamus is likely unsafe when taken by mouth during pregnancy or breast-feeding. Avoid use.
Heart conditions: Calamus might lower blood pressure and heart rate. Taking large amounts of calamus might worsen heart problems in some people with heart conditions.
Surgery: Calamus can affect the central nervous system. It might cause too much sleepiness if combined with medications used during and after surgery. Stop using calamus at least 2 weeks before a scheduled surgery.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with CalamusSome medications are changed and broken down by the liver. Calamus might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with CalamusSome medications are changed and broken down by the liver. Calamus might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications for depression (MAOIs) interacts with CalamusCalamus contains a chemical that affects the body. This chemical might increase the side effects of some medications used for depression. Some common MAOIs include phenelzine (Nardil), selegiline (Zelapar), and tranylcypromine (Parnate).
- Sedative medications (CNS depressants) interacts with CalamusCalamus might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking calamus with sedative medications might cause breathing problems and/or too much sleepiness.
- Drying medications (Anticholinergic drugs) interacts with CalamusCalamus can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking calamus might decrease the effects of anticholinergic drugs.
- Medications for high blood pressure (Antihypertensive drugs) interacts with CalamusCalamus might lower blood pressure. Taking calamus along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
- Various medications used for glaucoma, Alzheimer disease, and other conditions (Cholinergic drugs) interacts with CalamusCalamus can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking calamus with these medications might increase the chance of side effects.
Minor Interaction
Be watchful with this combination
- Antacids interacts with CalamusAntacids are used to decrease stomach acid. Calamus can increase stomach acid. Taking calamus might decrease the effects of antacids.
- Medications that decrease stomach acid (H2-blockers) interacts with CalamusH2-blockers are used to decrease stomach acid. Calamus can increase stomach acid. Taking calamus might decrease the effects of H2-blockers. Some common H2-blockers include cimetidine (Tagamet), ranitidine (Zantac), and famotidine (Pepcid).
- Medications that decrease stomach acid (Proton pump inhibitors) interacts with CalamusProton pump inhibitors are used to decrease stomach acid. Calamus can increase stomach acid. Taking calamus might decrease the effects of proton pump inhibitors. Some common proton pump inhibitors include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium).
Dosing
There isn't enough reliable information to know what an appropriate dose of calamus might be. It might also be unsafe. Speak with a healthcare provider before use.
References
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publ, 1997.
- Shoba, F. G. and Thomas, M. Study of antidiarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J Ethnopharmacol 2001;76(1):73-76.
- Cho, J., Kong, J. Y., Jeong, D. Y., Lee, K. D., Lee, D. U., and Kang, B. S. NMDA recepter-mediated neuroprotection by essential oils from the rhizomes of Acorus gramineus. Life Sci. 2-16-2001;68(13):1567-1573.
- Acuna, U. M., Atha, D. E., Ma, J., Nee, M. H., and Kennelly, E. J. Antioxidant capacities of ten edible North American plants. Phytother Res 2002;16(1):63-65.
- Parab, R. S. and Mengi, S. A. Hypolipidemic activity of Acorus calamus L. in rats. Fitoterapia 2002;73(6):451-455.
- Mehrotra, S., Mishra, K. P., Maurya, R., Srimal, R. C., Yadav, V. S., Pandey, R., and Singh, V. K. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol 2003;3(1):53-61.
- Koo, B. S., Park, K. S., Ha, J. H., Park, J. H., Lim, J. C., and Lee, D. U. Inhibitory effects of the fragrance inhalation of essential oil from Acorus gramineus on central nervous system. Biol Pharm.Bull. 2003;26(7):978-982.
- Lee, J. Y., Lee, J. Y., Yun, B. S., and Hwang, B. K. Antifungal activity of beta-asarone from rhizomes of Acorus gramineus. J Agric.Food Chem. 2-25-2004;52(4):776-780.
- Oh, M. H., Houghton, P. J., Whang, W. K., and Cho, J. H. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 2004;11(6):544-548.
- Hanson, K. M., Gayton-Ely, M., Holland, L. A., Zehr, P. S., and Soderberg, B. C. Rapid assessment of beta-asarone content of Acorus calamus by micellar electrokinetic capillary chromatography. Electrophoresis 2005;26(4-5):943-946.
- Liao, W. P., Chen, L., Yi, Y. H., Sun, W. W., Gao, M. M., Su, T., and Yang, S. Q. Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. Epilepsia 2005;46 Suppl 1:21-24.
- Manikandan, S. and Devi, R. S. Antioxidant property of alpha-asarone against noise-stress-induced changes in different regions of rat brain. Pharmacol Res 2005;52(6):467-474.
- Komalamisra, N., Trongtokit, Y., Rongsriyam, Y., and Apiwathnasorn, C. Screening for larvicidal activity in some Thai plants against four mosquito vector species. Southeast Asian J Trop.Med Public Health 2005;36(6):1412-1422.
- Shukla, P. K., Khanna, V. K., Ali, M. M., Maurya, R., Khan, M. Y., and Srimal, R. C. Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat. Hum.Exp Toxicol 2006;25(4):187-194.
- Aqil, F., Ahmad, I., and Owais, M. Evaluation of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts. Biotechnol.J 2006;1(10):1093-1102.
- Gilani, A. U., Shah, A. J., Ahmad, M., and Shaheen, F. Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade. Phytother Res 2006;20(12):1080-1084.
- Panchal, G. M., Venkatakrishna-Bhatt, H., Doctor, R. B., and Vajpayee, S. Pharmacology of Acorus calamus L. Indian J Exp.Biol 1989;27(6):561-567.
- Hu, B. Y. and Ji, Y. Y. [Research on the anticarcinogenic activation of Acorus calcamus. Anticarcinogenic activation of alpha-asarone on human carcinoma cells]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1986;6(8):480-3, 454.
- Vargas, C. P., Wolf, L. R., Gamm, S. R., and Koontz, K. Getting to the root (Acorus calamus) of the problem. J Toxicol Clin Toxicol 1998;36(3):259-260.
- Parab, R. S. and Mengi, S. A. Evaluation of hypolipidemic activity of Acorus calamus Linn. in rats. Indian Drugs (India) 2003;40:25-29.
- Pratap, S., Kumar, P., Reddy, D., and Reddy, M. Toxicity studies of selected indian medicinal plants against house fly, Chrysomiya & Culex quinquifasciatus (MAPS-P-412). International Pharmaceutical Federation World Congress 2002;62:134.
- Chen QX, Miao JK, Li C, Li XW, Wu XM, Zhang XP. Anticonvulsant activity of acute and chronic treatment with a-asarone from Acorus gramineus in seizure models. Biol Pharm Bull 2013;36(1):23-30.
- Chen HP, Yang K, Zheng LS, You CX, Cai Q, Wang CF. Repellant and insecticidal activities of shyobunone and isoshyobunone derived from the essential oil of Acorus calamus rhizomes. Pharmacogn Mag 2015;11(44):675-81.
- Katyal J, Sarangal V, Gupta YK. Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine. Indian J Exp Biol 2012;50(1):51-5.
- Nath P, Yadav AK. Anthelmintic activity of a standardized extract from the rhizomes of Acorus calamus Linn. (Acoraceae) against experimentally induced cestodiasis in rats. J Intercult Ethnopharmacol 2016;5(4):390-395.
- Pandit S, Mukherjee PK, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of a-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 2011;82(3):369-74.
- Rajput SB, Shinde RB, Routh MM, Karuppayil SM. Anti-Candida properties of asaronaldehyde of Acorus gramineus rhizome and three structural isomers. Chin Med. 2013;8(1):18.
- Rajput SB, Tonge MB, Karuppayil SM. An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species. Phytomedicine 2014;21(3):268-76
- Sharma V, Singh I, Chaudhary P. Acorus calamus (The Healing Plant): a review on its medicinal potential, micropropagation and conservation. Nat Prod Res. 2014;28(18):1454-66.
- Vijayapandi P, Annabathina V, SivaNagaSrikanth B, et al. In vitro anticholinergic and antihistaminic activities of Acorus calamus Linn. leaves extracts. Afr J Tradit Complement Altern Med 2012;10(1):95-101.
- Björnstad K, Helander A, Hultén P, Beck O. Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications. J Anal Toxicol 2009;33(9):604-9.
- Federal Register. Volume 33, Page 6967. U.S. Government Publishing Office. https://api.fdsys.gov/link?collection=fr&volume=33&page=6967. Accessed May 23, 2018.
- Electronic Code of Federal Regulations. Title 21. Part 189 - Substances Prohibited From Use in Human Food. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=259fa8a1284cad42676075c8425c7333&mc=true&node=pt21.3.189&rgn=div5.
- Zhang T, Yang J, Xu H, et al. Acorus tatarinowii alleviates D-galactose-induced Alzheimer's-like disease cognitive impairment and Aß-induced pericytes dysfunction in mice. Brain Res 2025;1847:149312.