Caffeic Acid
OTHER NAME(S): 3,4-DA, 3,4-Dihydroxycinnamic Acid, 2-Propenoic Acid, 3-(3,4-dihydroxyphenyl), 3-(3,4-Dihydroxy Phenyl)-2-Propenoic Acid, 3-(3,4-Dihydroxyphenyl)Propenoic Acid, 3,4-Dihydroxybenzeneacrylic Acid, 4-(2-Carboxyethenyl)-1,2-Dihydroxybenzene, 4-(2'-Carboxyvinyl)-1,2-Dihydroxybenzene, (2E)-3-(3,4-Dihydroxyphenyl)-2-Propenoic Acid, Ácido Cafeico, 3,4-dihydroxycinnamic acid, Ácido cafeico, Acide Caféique
Overview
Caffeic acid is a type of phenolic acid found in many plants and foods, such as apples and red wine. Coffee is the main source of caffeic acid in the diet.
Caffeic acid might have antioxidant and anti-inflammatory effects. It might also have effects on the immune system.
People use caffeic acid for athletic performance, obesity, and other purposes, but there is no good scientific evidence to support these uses.
Uses
We currently have no information for Caffeic Acid overview.
Side Effects
When taken by mouth: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine or what the side effects might be.
Precautions
When taken by mouth: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine or what the side effects might be.
Pregnancy and breast-feeding: Caffeic acid is commonly consumed in foods. But there isn't enough reliable information to know if caffeic acid is safe to use as medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.
Insomnia. Caffeic acid might have a mild stimulating effect that could make insomnia worse. But this effect is much less than with caffeine.
Interactions
Moderate Interaction
Be cautious with this combination
- Medications moved by pumps in cells (Organic anion transporter 1 (OAT1) substrates) interacts with Caffeic AcidSome medications are moved in and out of cells by pumps. Caffeic acid might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
- Medications moved by pumps in cells (Organic anion transporter 3 (OAT3) substrates) interacts with Caffeic AcidSome medications are moved in and out of cells by pumps. Caffeic acid might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Minor Interaction
Be watchful with this combination
- Levodopa interacts with Caffeic AcidCaffeic acid might change the way the body breaks down and gets rid of levodopa. But it's not clear if this is a big concern.
Dosing
Caffeic acid is found in many plants and foods. Coffee is the biggest source of caffeic acid in the diet, but it's also found in red wine, berries, apples, olives, artichokes, and pears. As medicine, there isn't enough reliable information to know what an appropriate dose of caffeic acid might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
References
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- Wang LH, Hsu KY, Uang YS, et al. Caffeic acid improves the bioavailability of L-dopa in rabbit plasma. Phytother Res 2010;24:852-8.
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- Grabska-Kobylecka I, Kaczmarek-Bak J, Figlus M, et al. The presence of caffeic acid in cerebrospinal fluid: Evidence that dietary polyphenols can cross the blood-brain barrier in humans. Nutrients. 2020;12(5):1531.
- Paciello F, Di Pino A, Rolesi R, et al. Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss. Food Chem Toxicol. 2020;143:111555.